1. DR SANTOSH KUMAR ASSISTANT PROFESSOR MEDICINE UNTI 2

2. Auto immune disease are condition in which the immune system damages its own bodt tissue causes ill health. auto immune disease include graves disease,hashimoto thyroiditis pernicious anemia,insulin dependent diabeted mellitus and rheumatoid arthritis and systemic lupus erythematous.

3. Systemic lupus Erythematous [SLE] SLE is an inflammatory,multisystem disorder with sign and symptom of artharlgia and rashes,with cerebral and renal disease as serious complication.

4. Epidemiology SLE occurs world wide More common in women then male (9:1) Peak age of onset b/w 20-40 years

5. CAUSES Unkown but predisposing factor like, Heredity Genetics Complement deficiency Sex hormone

6. Pathogeenesis It is immunological response to lupus (antigen presenting cells)stimulate B cell to producing antibodies against Ro and la eg.

7. Pathology SLE is a vasculitis affecting capillaries,arterioles and venules,with fibrinoid material is found in venules and tissue fibers.

8. Clinical feature Fever is common occur 50% of cases. Joints and muscles Skin Lungs Cardiovascular system Kidneys Nervous system Eyes G I T

9. LUPUS Variants Chronic discoid lupus Drug induced SLE Over lap syndrome Anti phospholipid syndrome

10. Investigations Complete blood picture Serum anti nuclear antibdies dsDNA antibody Other antibodies,,,,, Rheumatic factor 25% of pts Serum complement level Anti phospholipid antibodies Histology Imaging

11. Treatment Confirmed diagnosis Counselled about disease prognosis,prevention of complication and sun light exposure NSAIDs Antimalarial drugs Corticosteroids Immunosuppressive drugs New therapy like Anti –CD20 monoclonal antibodies and new trials ongoing

12. Prognosis SLE episodic or remissions phase Chronic persistent condition 10 year survival is about 90%,but lower in organ based complication.

20. thanks