1. SIMPLY SMARTER ™ PATIENT MONITORING AND DIAGNOSTIC EQUIPMENT SOLUTIONS

2. 2 Medical Solutions Introduction Purpose Introduce Intersil solutions for patient monitors and medical diagnostic equipment Objectives Overview of several sub-blocks of the patient monitor systems and various medical diagnostic equipment Present Intersil feature products with select application circuits Content 16 pages Learning time 30-40 minutes (estimated)

3. 3 Patient Monitors –High Level System

4. 4 Intersil Products Products Highlighted Op Amps Data Converters Switches and Multiplexers RS-485/422 Interfaces Voltage references Digital Potentiometers (DCPs) Real Time Clocks PWM Controllers Integrated FET Switching Regulators Isolated Power Battery Chargers Voltage monitoring Other Intersil Products Ambient Light Sensor/Proximity Detector LED Backlighting Audio Amplifiers

5. 5 ECG / EKG ECG signals basics Typically 0.05 Hz to 150 Hz bandwidth, 1mV to 10mV pp Systems are EMI sensitive Analog Frontend Requirements Low noise at low frequency, high impedance (low leakage) components are required –ISL28110 for low noise, high impedance body probe buffers –ISL28217 for right leg drivers Other analog components: –ISL54500 for lead switching –ISL21009D for low power VREFs Accuracy depends on AC or DC coupling approach from 10-bit to 16-bit. Power Multi output voltage solutions for powering processors or FPGA –ISL9440A triple output controller and single LDO controller generates the rails for a FPGA. –ISL80101 LDO family can reduce EMI in noise sensitive areas.

6. 6 Blood Pressure (NiBP) - Non-Invasive Blood Pressure Pressure Sensor Basics Strain Gauge, R OUT ≈ 5kΩ, 0-300mm Hg Range, FS OUT = 300mV, BW = 5Hz Analog Frontend Requirements Low noise and gain signal conditioning. Low noise at low frequency, high DC accuracy, low power vs. low noise –ISL28217 or ISL28233 for low noise, high voltage for gain amplification (10x to 20x) Active Filters. Low pass filters for cuff pressure. Bandpass filters to capture oscillations, ISL28217 or ISL28233, use INTERSIL’S FILTER DESIGNER. See Intersil’s Medical Brochure for other analog components. http://www.intersil.com/literature/images/LC- 097.pdf http://www.intersil.com/literature/images/LC- 097.pdf Power For portable monitors, efficiency and size are the main focus. –ISL9440A, ISL9104, ISL8033 are some of the products that can power the FPGA and also work well to generate the power to the amplifiers in the system. http://web.transim.com/iSimFilter/Pages/DesignReq.aspx

7. 7 SpO2 – Pulse Oximetry (saturation oxygen in blood) Pulse Oximetry Basics Pulse Oximetry is the non-invasive measurement of the arterial blood’s oxygen saturation. Detectors are needed to determine deoxygenated vs. oxygenated blood. Analog Frontend Requirements Diagnostic SpO2 typically uses JFET-input op amps, or CMOS op amps are used to construct the transimpedance amplifier frontends. –The ISL28110/210 is a precision JFET-input op amp that can be used for these applications because of its low noise and high impedance. Power The majority of these oximetry monitors are portable and run from 1 or 2 cell Li-ion batteries. These are rechargeable devices. –The ISL9220A can be used in these applications to recharge at higher efficiency with up to 2A charge current. –The ISL9104 fully integrated 500mA Switching regulator can be used to generate a very compact switching solution because of its high switching frequency.

8. 8 Body Temperature Temperature Sensor Basics Type varies for surgical, patient-care, home care. Typically either infrared, thermistor, or thermopile/ pyroelectric sensors. System consists of a small sensor voltage, then gain and filter signal conditioning. Analog Frontend Requirements Diagnostic (professional) vs. home use (ear-type) vary. For diagnostic body temp monitors, use precision op amps for signal conditioning. –Intersil provides several options for high DC precision, low temperature offset drift and lower power : –For IR sensors: ISL28130 Low Cost, Low Power –For Thermistor: ISL28217, ISL28207, ISL28218 for precision –For Pyroelectric/Thermopile: ISL28110, ISL28133, ISL28217 Power Making the power solution compact with a reduced BOM is critical. –The low current switching regulators and multi- output low current LDO’s are a good fit for power here. ISL3232 ISL4221E

9. SIMPLY SMARTER ™ Product Specifics

10. 10 ISL28110/210: JFET-Input, Low Noise Op Amps FeatureBenefit Low Input Bias Current: 2pA max @ room 4.5pA max @ 60°C 50pA max @ 85°C High input impedance sensors Photodiode, amperometric, transimpedance application Low Voltage Noise: 6nV/√Hz @ 1kHz 580 nVpp @ 0.1Hz to 10Hz Low Current Noise: 9fA/√Hz @ 1kHz Low noise for better accuracy and improved SNR Precision Low offset voltage: 300µV max Low Drift: 1µV/°C Precision signal conditioning Superior AC (Dynamic) Performance BW = 12.5MHz Slew Rate = 23V/µs THD = 0.00002% (G=1, f=1kHz, 4Vpp, R L =2kΩ) Ideal for high performance instrumentation, DAQ Operating Voltage: 9 to 40V or ±4.5V to ±20V Wide operating voltage range Outstanding Noise Performance Low Bias Current of TIA Applications High Impedance Buffers

11. 11 Precision Low Noise JFET Operational Amplifier. Competitive Summary Medical Applications Pulse Oximetry ECG/EEG In Vitro – Biochemical Analyzers Anesthesia Equipment Blood Flow Measurement 10x Better 300 fA Typical ISL28110/210 Superior Low I BIAS and Noise Performance

12. 12 ISL28130/230/430: 1.65V to 6V Micropower Rail-Rail, Precision Amps FeatureBenefit Precision Low offset voltage: 40µV max Low Offset Drift: 150nV/°C max DC Accuracy for 12-bit to 16-bit applications Operating Voltage: Rail-Rail Input and Output 1.65V to 6V Single Supply ±0.825V to ±2.75V Dual Supply Lowest operating voltage vs. competition, allows operation at low battery levels Low Power 25µA max Low power consumption for precision Low Voltage Noise: 1.1 µV p-p @ 0.01 Hz to 10Hz Ideal for high performance instrumentation, DAQ Low Cost Precision (single/dual/quad) Ideal for medical consumer applications Ear Thermometer Temperature ISL28130 1.65V ISL28130 0.825V - 0.825V Lowest Operating Voltages

13. 13 ISL9440A: Triple Output PWM Controller With a Single LDO Controller FeatureBenefit Integration Three fully integrated PWM controllers and one LDO controller Single solution to generate three rails to power a Processor/FPGA Separate rail control Separate enable and power good Independently programmable voltage outputs Allows user to power on or off each rail independent of the other rails. Facilitates ease of sequencing Synchronous regulation Each switching rail is fully synchronous Gives a more efficient method of delivering power to the load Out of Phase switching 0°/180°/0° Phase shift between channels Allows for reduction of RMS input current and voltage ripple so input capacitance can be reduced Protection Integrated UV/OV/OC/OT protection Provides protection against various fault modes Medical Applications ECG / EEG Imaging systems Patient monitoring Dialysis machines

14. 14 ISL9220: Switching Charger for 1 & 2 Cell Li-Ion Batteries FeatureBenefit Switching topology Synchronous Buck Topology, with Integrated Power FETs More efficient charging of 1 and 2 cell Li-ion batteries 90% + efficiency to optimize the charging time Integration Integrated FET’s for a fully Synchronous & compact solution Allows for a compact solution Fewer external components Charging current Up to 2A charging current Allows faster charging or helps to reduce charge time VBAT = 3.6V VBAT = 3.0V VBAT = 4.0V

15. 15 ISL9305: Compact Power Management IC Reduces Complexity Available in WLCSP & QFN packages I2C interface to set voltage, set on/off sequence and En/Disable PFM mode 15mV Pk-Pk PFM ripple Excellent load transient response Dual High Fsw Buck + Dual Low VIN LDO 3MHz fixed switching frequency 800 mA from the buck regulators (H version: 1500mA) 300mA output current from the LDOs

16. 16 ISL9103/4: Low Power Switching Regulator 2.5MHz/4.3MHz Synchronous Buck Regulator with up to 95% efficiency 500mA Buck Regulator with high switching frequency and ultrasonic mode of operation Low Quiescent current of 20µA IQ in PFM Mode 2.7V to 6V Vin range 3% Output Accuracy Over-Temperature and Line for Fixed Output Options 100% Maximum Duty Cycle for Lowest Dropout Discharge Output Capacitor when Disabled Tiny 1.6x1.6mm Package Tiny 1µH inductor

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