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Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury by John C. Elfar, Justin A. Jacobson, J. Edward Puzas, Randy N. Rosier, and.

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Presentation on theme: "Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury by John C. Elfar, Justin A. Jacobson, J. Edward Puzas, Randy N. Rosier, and."— Presentation transcript:

1 Erythropoietin Accelerates Functional Recovery After Peripheral Nerve Injury by John C. Elfar, Justin A. Jacobson, J. Edward Puzas, Randy N. Rosier, and Michael J. Zuscik J Bone Joint Surg Am Volume 90(8):1644-1653 August 1, 2008 ©2008 by The Journal of Bone and Joint Surgery, Inc.

2 Representative control footprint demonstrating measurements used to calculate the sciatic function index. John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644- 1653 ©2008 by The Journal of Bone and Joint Surgery, Inc.

3 Effects of sciatic crush injury on the sciatic function index. John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644- 1653 ©2008 by The Journal of Bone and Joint Surgery, Inc.

4 John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644- 1653 ©2008 by The Journal of Bone and Joint Surgery, Inc.

5 John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644- 1653 ©2008 by The Journal of Bone and Joint Surgery, Inc.

6 Effect of timing of erythropoietin administration (5000 U/kg administered by subcutaneous injection) on the sciatic function index in mice subjected to a sciatic crush injury (for a sixty- second duration) as described in the Materials and Methods section. John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644- 1653 ©2008 by The Journal of Bone and Joint Surgery, Inc.

7 Immunohistochemical staining of erythropoietin receptors in sciatic nerve tissue harvested from mice subjected to sciatic injury or sham surgery with or without erythropoietin administration. John C. Elfar et al. J Bone Joint Surg Am 2008;90:1644- 1653 ©2008 by The Journal of Bone and Joint Surgery, Inc.


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