1. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Polygram 98 Anorectal Function Testing Markers and Calculations

2. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Analysis Marker Overview Resting Pressure Analysis Marker Squeeze Analysis Marker Strain Analysis Marker Cough Analysis Marker Generic Calculation Analysis Marker RAIR Analysis Marker Rectal Sensation Analysis Marker Baseline Analysis Marker Continuous Pull Resting Pressure Analysis Marker Continuous Pull Squeeze Analysis Marker

3. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Reference Level Calibrated Zero Resting Pressure relative to Calibrated Zero Pressure Amplitude relative to Calibrated Zero Pressure Increase relative to Baseline Baseline Resting Pressure relative to Baseline Pressure Amplitude relative to Baseline Pressure Increase relative to local Resting Pressure Applies for following markers: Resting Pressure Analysis Marker Squeeze Analysis Marker Strain Analysis Marker Cough Analysis Marker

4. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL External anal sphincter Resting Pressure Analysis Marker Resting Pressure Level

5. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Internal anal sphincter External anal sphincter Resting Pressure – Fixed Catheter

6. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Internal anal sphincter External anal sphincter Resting Pressure – Station Pull

7. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Squeeze Analysis Marker – Calib. Zero Contraction Pressure Increase Pressure Amplitude Duration Analysis Marker Duration Pressure Increase (Contr.) Pressure Amplitude (Contr.) Duration (Contr.)

8. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Squeeze Analysis Marker – Baseline Contraction Pressure Increase Pressure Amplitude Duration Analysis Marker Resting Pressure Duration Pressure Increase (Contr.) Pressure Amplitude (Contr.) Duration (Contr.)

9. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Contraction Identification Calibrated Zero Baseline

10. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Squeeze Analysis – Fixed Catheter

11. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Squeeze Analysis – Station Pull

12. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Strain Analysis Marker – Calib. Zero Contraction Pressure Increase Pressure Amplitude Duration Analysis Marker Duration Pressure Increase (Contr.) Pressure Amplitude (Contr.) Duration (Contr.)

13. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Strain Analysis Marker – Baseline Contraction Pressure Increase Pressure Amplitude Duration Analysis Marker Resting Pressure Duration Pressure Increase (Contr.) Pressure Amplitude (Contr.) Duration (Contr.)

14. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Strain Analysis – Fixed Catheter

15. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Cough Analysis Marker – Calib. Zero Contraction Pressure Increase Pressure Amplitude Duration Analysis Marker Duration Pressure Increase (Contr.) Pressure Amplitude (Contr.) Duration (Contr.)

16. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Cough Analysis Marker – Baseline Contraction Pressure Increase Pressure Amplitude Duration Analysis Marker Resting Pressure Duration Pressure Increase (Contr.) Pressure Amplitude (Contr.) Duration (Contr.)

17. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Cough Analysis – Fixed Catheter

18. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Generic Analysis Marker Min pressure Max pressure Mean pressure Median pressure Motility Index

19. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Generic Analysis

20. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL RAIR Analysis Marker No analysis User specified balloon volume User specified classification (present/non-present)

21. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Rectal Sensation Analysis Marker No analysis User specified balloon volume User specified classification (first sensation, constant sensation, maximum tolerable volume)

22. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Continuous Pull Analysis Marker Sphincter/HPZ Length Max pressure Mean pressure Pull Sphincter Length HPZ Length Max pressure HPZ Mean pressure HPZ Sphincter Asymmetry HPZ Asymmetry Sphincter Vector Volume HPZ Vector Volume Pull data

23. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Continuous Pull Analysis Marker

24. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Continuous Pull - Summary

25. FUNCTIONAL DIAGNOSTICS GASTROINTESTINAL Continuous Pull - Details