1. BME 560 Medical Imaging: X-ray, CT, and Nuclear Methods Radiation Physics Part 1

2. Today Forms of Radiation Particulate Radiation –Electron interactions with matter EM Radiation Nuclear Transitions Decay

3. What is Radiation? Radiation: Energy in the form of traveling waves or subatomic particles moving through space –May or may not have mass –May or may not have charge

4. Types of Radiation Ionizing: capable of producing an ion pair from interaction with an atom –Usually with energy > 13.6 eV Non-ionizing: incapable of producing an ion pair Ion pairs are reactive and may cause biological damage

5. Radiation

6. Forms of Radiation Particulate: particle-based, has mass –Protons, neutrons, electrons, positrons, alphas Electromagnetic: no mass –Gamma rays, X-rays, Ultraviolet Examples: –X-ray tubes –PET radionuclides

7. Ionization and Excitation Both transfer energy to an orbital electron –Let E b be the electron binding energy –Ionization: Energy is enough to remove electron from orbit –Excitation: Energy is enough to transition electron to higher orbital –In both cases, the hole will be filled and energy released. Radiation (E) KL M N Ejected electron (E e )

8. Particulate Radiation Alpha particle: He nucleus (2 protons, 2 neutrons) Beta particle: Electron (  -) or positron (  +) Proton Neutron

9. Particulate Radiation Properties: –Alpha: very high mass, highly charged, very highly ionizing, very low penetration –Beta: low mass, charged, highly ionizing, low penetration –Proton: high mass, charged, highly ionizing, low penetration –Neutron: high mass, no charge, less ionizing, unusual penetration properties In all cases, penetration depends on energy.

10. Particulate Radiation Medical uses: –Alpha: Radiotherapy –Beta: X-ray production, PET imaging, Radiotherapy –Proton: Radiotherapy –Neutron: Radiotherapy So we are primarily interested in electrons and positrons for imaging.

11. Energetic Electron Energy Transfer How electrons lose energy to a medium: –Collisional transfer: Interaction between particle and orbital electrons High-energy: Ionization Low-energy: Heat Energetic electron loses kinetic energy –Radiative Transfer: Energy transfer results in production of X-ray Characteristic X-rays Bremsstrahlung radiation

12. Energetic electron energy transfer

13. Energy loss rate vs. electron energy in water and lead therapy diagnostic Pb 207 82

14. Characteristic X-rays Electron moves from higher energy level to a lower energy level. Since the orbital energy levels are well defined for individual elements, each element has its own characteristic transitions. –These are very specific energy levels. Usually, it is the transitions into the K shell that are important.

15. Characteristic X-rays

16. Bremsstrahlung “Braking radiation” The effect of charge-charge interaction between an energetic electron and an atomic nucleus The electron slows and releases energy in the form of an X-ray photon. Bremsstrahlung X-rays may have any energy up to the energy of the incident electrons.

17. “White” bremsstrahlung x-rays Filtered x-rays

18. Bremsstrahlung production Efficiency = 9 x 10 -10 Z (atomic number) V (voltage) (This is an approximation.) Efficiency: the ratio of the Bremsstrahlung x-ray energy to the incident electron energy. The remaining portion of the electron energy (1 - Efficiency) is converted into heat in the x-ray target. Anode heating is a major issue in x-ray tubes. Exercise: Calculate the efficiency for x-ray production for 100keV electron beams on tungsten (Z = 74).

19. Exercises: What is the rest energy of an electron? (mass = 9.11 x 10 -28 g) What is the rest energy of a proton? (mass = 1.67 x 10 -24 g) Electron energy, mass and velocity Kinetic energy (KE)

20. EM Radiation Electromagnetic radiation is considered in the form of photons. –No charge, no mass –The wavelengths of interest are much smaller than the scales of typical interactions, so we are safe to treat this radiation as “particles” rather than “waves”.

21. EM Radiation X-rays versus gamma-rays (or gamma particles) –Physically, they are the same thing. –X-rays: Produced by energetic electrons striking a material Man-made Secondary effects –Gamma-rays: Produced by radioactive decay of materials

22. Radiation

23. Electromagnetic (EM) radiation Energy (keV): 1 eV = 1.602 x 10 -19 J Frequency (Hz): E = hf (Hz) Planck Constant: h = 6.625 x 10 -27 erg-second = 4.136 x 10 -15 eV-s Wavelength ( ): E (keV)= 1.24 / (nm)

24. (Physical Principles of Medical Imaging by Perry Sprawls)

25. X-ray production process in imaging and therapy systems involves both particulate and EM types of radiation 1)Free electron production (temporal res. control) Electrons are “pulled” out of filament (thermionic or field emission). 1)Electron acceleration Electron energy under voltage (E = eV) 3)Electron bombards anode to produce Bremsstrahlung x-rays (spatial res. Control- focal spot size) Once x-rays are generated, they are shaped and controlled to suit the need of the specific application.

26. EM Radiation Interactions with matter –Rayleigh scatter –Photoelectric effect –Compton scatter –Pair production; positron annihilation More next time

27. Radioisotopes Gamma photons are given off as unstable or metastable isotopes try to go to a more stable atomic state. The nuclear transitions are well defined for a given isotope. –Specific energies are emitted –Sometimes, there are multiple transition paths; thus, multiple energies.

28. Atomic Structure Atomic structure –Nucleus (Z protons and N neutrons) –Z orbital electrons Atomic number: Z (element) Mass number: A = Z+ N (total number of nucleons) Symbols element Atomic number mass number

29. Radionuclide Definition: Certain natural and man-made atoms with unstable nucleus that can undergo spontaneous breakup or decay and, in the process, emit alpha, beta, or gamma radiation. Naturally occurring radionuclides (U-238, Ra-226, Rn-222) Man-made radionuclides (isotope) –All radionuclides for diagnostics and therapy are man-made. Therapy: I-125, Ir-192, Cs-137, Co-60, etc. Diagnostic: Ga-67, Tc-99, I-131, C-11, O-15, etc.

30. Nucleus instability and decay A nucleus with excess energy is at an excited state. It will release the energy and go to the ground (energy) stable state eventually. N/P (number of neutrons over protons) ratio is a good indicator of nucleus stability. For low (<15) Z atoms, the stable N/P ratio is 1.0 and it increases to ~1.5 for high Z atoms. N/P =1 H He Li Be B C N O F Ne Na Mg Al Si P S

31. Nuclear transitions There are several ways an unstable nucleus can decay: Isotopic transition (mother and daughter nuclei have the same number of protons) – Lose a neutron Isobaric transition (different number of protons but same number of nucleons (N+P)) – Exchange proton and neutron Isomeric transition (different energy levels) – Lose energy from nucleus Isotonic transition (have the same number of neutrons) – Lose a proton Isotopes, isobars, isomers, and isotones.

32. Examples of isobars, isotones, and isotopes Products of radioactive decay: Beta particle (electron) Isobaric transition Positron Isobaric transition Electron capture Isobaric transition Gamma ray Isomeric transition Alpha particle Secondary decay products: Characteristic x-rays Auger electrons Isotones

33. Examples

34. Nuclear Transitions in Medicine Isobaric (exchange neutron and proton) –  - emission (high N/P ratio) Neutron > proton +  - + neutrino –  + emission (low N/P ratio) Proton > neutron +  + + neutrino –Electron capture (low N/P ratio) Proton + K-shell e- > neutron + gamma Isomeric (lose energy from nucleus) –Gamma emission –Internal conversion Atom ionizes itself;  - emitted

35. Composite diagram of nuclear transitions Stable N/P K shell High N/P Low N/P positron beta Electron capture Gamma Internal conversion electron Auger X-rays Z, atomic number energy

36. Activity (A) A measure of the rate a radioactive nucleus decays. Activity is the change of total number of original radioactive nuclei (N) in a given time (dt): Question: If two different gamma-ray emitting radionuclides have the same radioactivity, do they give the same photon flux? (Flux = photons/area/time)

37. Activity Units: curie (Ci) and becquerel (Bq) Ci = 3.7 x 10 10 dps Bq = 1 dps dps: disintegrations per second Curie is a very large quantity of radioactivity. Commonly used activity level is ~ 100 mCi for therapy and ~ mCi for diagnostics. The SI unit is becquerel and 1mCi = 37M Bq.

38. Decay constant Decay constant  is the fraction of radionuclei decayed per time. F   min --> 0.63% per min I   day --> 1.17% per day

39. Half life T 1/2 T 1/2 : time for 50% of the original radionuclides to decay. N remaining = N original /2 n (n: number of half lives elapsed)

40. Radioactive Decay Activity remaining for 24 hours for common SPECT (99m-Tc) and PET (18-F) isotopes

41. Measure of Radiation Radiation dose Definition: ionization energy absorbed per unit mass. Dose (Gy) = Energy (J)/ Mass (kg) Radiation Exposure Definition: ionization charge collected per unit mass of air. Exposure (R) = charge (Q)/Mass (kg)| air Roughly speaking: Dose (cGy) ~ Exposure (R)