1. SNMX FACT SHEET About Senomyx Utilizing Taste Science Innovations to Discover & Develop Novel Flavor Ingredients for the Global Food & Beverage Industry Senomyx uses proprietary technologies to discover & develop new flavor ingredients that provide nutritional and/or cost benefits while maintaining the taste desired by consumers. We have collaborations with global food, beverage, and ingredient supply companies, some of which are marketing products that contain flavor ingredients discovered and developed by Senomyx. Innovative Technologies Senomyx pioneered the use of robotic screening methods for the discovery of new flavor ingredients. Senomyx’s high-throughput screening systems perform millions of analyses each year, searching our extensive sample libraries to identify potential new flavor ingredients. Results are confirmed in taste tests with trained panelists. Our intellectual property portfolio has 345 issued and several hundred pending patents re. taste receptor sequences / functions, screening assays, ingredients, & product applications (9/30/12). Flavor Programs Senomyx is building a product pipeline of proprietary flavor ingredients that address the needs of the food & beverage industry.  Savory Taste Program – Reduce or replace added MSG in foods and beverages; create new savory ingredient blends Senomyx Savory Flavor Ingredients are being marketed by Nestlé and/or another partner in 25 countries within Africa, Asia, Latin America, the Middle East, and North America. S9229 & S5456, two new Savory Flavor Ingredients, have received Generally Recognized As Safe (GRAS) regulatory status, which expands Senomyx’s offerings & market opportunities.  Sweet Taste Program – Reduce added sugar or other sweeteners in foods and beverages; decrease product calories; potential cost savings & improved taste. S6973 Sucrose Modifier enables up to 50% reduction of sucrose (table sugar) in foods & selected beverages. Firmenich is marketing in the Americas, SE Asia, Africa, & Australia. S2383 Sucralose Modifier enables up to 75% reduction of the artificial sweetener sucralose. Firmenich is marketing S2383 for foods & beverages in North America & Latin America. S9632 New Sucrose Modifier enables up to 50% reduction of sucrose in a wide variety of foods and a broad range of beverages. Received GRAS designation September 2012. S52617 (S617) New High Fructose Corn Syrup (HFCS) & Sucrose Modifier enables a very meaningful reduction of both HFCS and sucrose in product prototypes while maintaining the desired sweetness. The preliminary development phase was initiated in 3Q12. Natural High-Potency Sweeteners & Sweet Taste Modifiers are a new discovery effort. A natural compound with a sweet taste was identified, an important taste-proof-of-concept.  Bitter Blockers Program – Improve palatability of foods & beverages S6821 & S7958 Bitter Blockers have GRAS & international regulatory approvals; reduce bitterness in foods & beverages, e.g., soy & whey proteins, menthol, caffeine, cocoa, stevia. A Senomyx partner initiated market launch of a retail product containing S6821 in a Southeast Asian country.  Salt Taste Program – Reduce added salt in foods & beverages; improve the nutritional profile of high-sodium products Senomyx is exploring the role of proteins believed to be involved in salt taste perception.  Cooling Taste Program - Create Cooling Flavors without the limitations of current agents New Cooling Agents are being evaluated by Senomyx and Firmenich. NASDAQ: SNMX Q1 2013 www.senomyx.com Sensing the Future Through Innovation

2. Collaborations Business Model Senomyx intends to maximize the revenue potential from our flavor ingredients by entering into collaborations with leading food, beverage, and ingredient supply companies. Senomyx’s collaborators are granted exclusive or co- exclusive use of the flavor ingredients resulting from one of our flavor programs, in specific product categories and geographies. The collaborators are responsible for manufacturing, sales, and marketing. Senomyx has received upfront payments, R&D funding, license fees, milestone payments, and royalties from the sales of our collaborators' products that contain our flavor ingredients. Collaborators currently marketing products that contain flavor ingredients discovered by Senomyx are Ajinomoto Co. Inc., Firmenich SA, and Nestlé SA. Financial Summary (As of 9/30/12) Cash Balance = approx. $44.7 mm No debt No warrants Royalty payments by collaborators through patent life 40.1 mm Shares Outstanding (10/31/12) Senior Management Kent Snyder - Chief Executive Officer and Chairman of the Board of Directors John Poyhonen - President and Chief Operating Officer Sharon Wicker - Senior Vice President and Chief Commercial Development Officer Donald Karanewsky, Ph.D. - Senior Vice President and Chief Scientific Officer David Berger – Senior Vice President, General Counsel and Corporate Secretary Susan Melody - Vice President, Human Resources David Linemeyer, Ph.D. - Vice President, Biology Lorenzo Peña - Vice President, Information Technology Tony Rogers – Senior Vice President & CFO Gwen Rosenberg - Vice President, Investor Relations & Corporate Communications Contact for Investors & Media Gwen Rosenberg Vice President, Investor Relations & Corporate Communications (858) 646-8369, gwen.rosenberg@senomyx.comgwen.rosenberg@senomyx.com Please visit Senomyx Cares, www.senomyx-csrblog.comwww.senomyx-csrblog.com NASDAQ: SNMX Q1 2013 www.senomyx.com Recent Updates A Senomyx partner initiated the first market launch of a retail product containing the Company’s S6821 Bitter Blocker Received GRAS regulatory status for S9632 sucrose modifier Development phase activities initiated for S52617 (S617), Senomyx’s first modifier for both HFCS & sucrose New international regulatory approvals open additional markets for modifiers of sucrose (S6973) & sucralose (S2383); Bitter Blockers S6821 & S7958 New market introductions by Senomyx partners of S6973 (sucrose), S2383 (sucralose) modifiers & Senomyx Savory Flavors Company Highlights Multiple flavor programs World-class collaborators Deep pipeline of potential new flavor ingredients Strong IP position Strong financial position Significant leverage opportunities No COGs, marketing, or manufacturing costs Industry ChallengesSenomyx Advantages Health Concerns / Social & Legislative IssuesImprove Nutritional Profile of Foods & Beverages Need Innovative Products Exclusivity Provides Competitive Advantages for Partners Cost PressuresDecrease / Control Partners’ COGS Taste Cannot be DiminishedMaintain / Enhance Taste Forward Looking Statement - Statements in this summary that are not strictly historical are forward-looking statements and involve a high degree of risk and uncertainty. The Company’s actual results may differ materially from those suggested herein. Additional information concerning factors that could cause such difference is contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2011 and its Quarterly Reports on Form 10-Q.