1. Stomach and Duodenum AnatomyAnatomy PhysiologyPhysiology Operative proceduresOperative procedures Gastric disordersGastric disorders peptic ulcer diseases tumors structural disorders inflammatory and infectious diseases traumas

6. Peptic ulcer diseases Major types ; duodenal ulcer gastric ulcer stomal ulcer Other types ; stress ulcer ulcers caused by gastric irritants steroid induced ulcer

7. Pathogenesis of peptic ulcer Lack of protection of the mucosa Acid production

8. Duodenal ulcer ;pathogenetic factors Increased acid secretion Environment ; 흡연, NSAIDS, Helicobacter Mucosal defense ; decreased bicarbonate production, decreased gastric prostaglandin production

9. Duodenal Ulcer : goals of operative therapy promotion of ulcer healing treatment of specific complications reduction of the possibility of recurrence minimization of postoperative side effects

10. surgically correctable components to reduce the acid secretion Cholinergic vagal stimuli Parietal cell mass Gastrin secretion

11. Duodenal Ulcer : operative procedures Truncal vagotomy and drainage Truncal vagotomy and antrectomy Parietal cell vagotomy Alternative methods

14. Gastric effects of truncal vagotomy Decreased acid secretion Increased serum gastrin Gastrin cell hyperplasia Accelerated liquid emptying Altered emptying of solid

15. Nongastric effects of truncal vagotomy Decreased pancreatic exocrine secretion Decreased postprandial bile flow Increased gallbladder volume Diminished release of vagally mediated peptide hormones

16. Drainage procedures : pyloroplasty Heineke-Mikulicz Finney Jaboulay

20. Duodenal Ulcer : operative procedures Truncal vagotomy and drainage Truncal vagotomy and antrectomy Parietal cell vagotomy Alternative methods

23. Duodenal Ulcer : operative procedures Truncal vagotomy and drainage Truncal vagotomy and antrectomy Parietal cell vagotomy Alternative methods

29. Duodenal Ulcer : operative procedures Truncal vagotomy and drainage Truncal vagotomy and antrectomy Parietal cell vagotomy Alternative methods

31. Duodenal Ulcer : choice of operation Location of ulcer Indication for operation Chronicity of the ulcer diathesis Age and sex, nutritional status of the patient Presence of concomitant illness Stability of the patient during the perioperative period Experience and personal preference of the surgeon

32. Duodenal Ulcer : indications for operation Intractability Perforation Obstruction Hemorrhage

33. Duodenal Ulcer : indications for operation Intractability Perforation Obstruction Hemorrhage

34. Intractability ; criteria Initial healing is delayed, so that ulceration persists at 3 months despite active drug therapy Ulcers recur within 1 year of initial healing despite maintenance therapy The ulcer disease is characterized by cycles of prolonged activity with brief or absent remissions

35. Operative procedures : intractability First choice; parietal cell vagotomy Alternatives ; truncal vagotomy and antrectomy laparoscopic vagotmy

36. Duodenal Ulcer : indications for operation Intractability Perforation Obstruction Hemorrhage

37. Clinical features ; perforated duodenal ulcer Symptoms ; sudden onset of severe epigastric pain spreading throughout the abdomen, variable degree of shock Signs ; abdominal tenderness, rigidity Plain X-ray ; peritoneal free air

39. Differential diagnosis ; perforated duodenal ulcer Acute cholecystitis Acute pancreatitis Strangulation obstruction Acute appendicitis Perforation of other G-I tract Mesenteric thrombosis

40. Operative procedures : perforation Simple closure Definitive surgery parietal cell vagotomy and omental patch truncal vagotomy and pyloroplasty truncal vagotomy and antrectomy

41. Indications for definitive operation No preoperative shock No life-threatening medical illness Perforation has been present for less than 48 hours

43. Duodenal Ulcer : indications for operation Intractability Perforation Obstruction Hemorrhage

44. Causes of obstruction in duodenal ulcer Inflammation and edema Fibrosis

45. Operative procedures : obstruction Truncal vagotomy and antrectomy Truncal vagotomy and gastrojejunostomy Parietal cell vagotomy with dilatation

47. Duodenal Ulcer : indications for operation Intractability Perforation Obstruction Hemorrhage

48. Indications for operative intervention ; duodenal ulcer bleeding Massive hemorrhage leading to shock Prolonged blood loss requiring continuing transfusion Recurrent bleeding during medical therapy or after endoscopic therapy Recurrent bleeding requiring hospitalization

49. Operative procedures : hemorrhage Truncal vagotomy and pyloroplasty with suture ligation of bleeding vessel Truncal vagotomy and antrectomy including ulcer or suture ligation of bleeding vessel

50. Timing of operation : hemorrhage Primary emergency Secondary emergency Early elective surgery

54. Location of gastric ulcers

55. Type I gastric ulcer 60% of GU Large volume of secretion with low or normal acid secretion

56. Type II gastric ulcer 25% of GU Usually acid hypersecretor DU usually precedes GU

57. Type III gastric ulcer 23% of GU Prepyloric ulcer Typically acid hypersecretor

58. Type IV gastric ulcer Less than 10% of GU High-lying ulcer

59. Predisposing factors ; gastric conditions Acid and pepsin Gastric stasis Coexisting duodenal ulcer Duodenogastric reflux Gastritis Helicobacter pylori

60. Predisposing factors ; clinical conditions Chronic alcohol use NSAIDS Smoking Long-term steroid therapy Infection Intraarterial chemotherapy

61. Gastric Ulcer : goals of elective operation Primary goals ; to excise the ulcer to reduce acid/pepsin output Secondary goals ; to minimize bile reflux and gastric stasis

62. Gastric ulcer : standard operations type I ; Distal gastrectomy and B-I anastomosis type II, III ; Distal gastrectomy with vagotomy type IV ; TV and draiage and biopsy/excision of ulcer Distal gastrectomy with ulcer excision Distal gastrectomy with biopsy of ulcer Proximal gastrectomy

66. Gastric Ulcer : indications for elective operation Failure to heal on optimal medical therapy Suspicion of malignancy Distal gastric obstruction Giant gastric ulcer

69. Gastric Ulcer : emergency operation Bleeding gastric ulcer Perforated gastric ulcer

70. Bleeding gastric ulcer : operative procedures Gastric resection including ulcer simple oversewing excision of ulcer with TV and drainage without TV and drainage

71. Gastric Ulcer : emergency operation Bleeding gastric ulcer Perforated gastric ulcer

72. Perforated gastric ulcer : operative procedures Gastric resection Biopsy and simple closure

74. New Surgical Strategy for Gastroduodenal Ulcer : Laparoscopic approach Truncal vagotomy Thoracoscopic truncal vagotomy Parietal cell vagotomy

75. Stress Ulcer Multiple superficial mucosal erosions after major physical trauma, shock, sepsis, hemorrhage, respiratory failure, or severe burns.

78. Surgical therapy Truncal vagotomy and drainage Truncal vagotomy and antrectomy Truncal vagotomy and subtotal gastrectomy Total gastrectomy Gastric devascularization