1. MITOSIS REVIEW Chapter 10 Test

2. ESSAY #1 How is cancer related to the cell cycle? Do not have a normally functioning cell cycle

3. How are cancer cells different from most cells? Divide excessively and can invade other tissue

9. ESSAY #2 STEM CELLS Cells that can turn into almost any kind of cell (not yet differentiated). Formed a few days after an egg and sperm join.

10. From embryos

11. Adult stem cells

12. Cord Blood

13. Stem Cell Animations "How Embryonic Stem Cell Lines are Made" Biology Animation Library :: Dolan DNA Learning Center"How Embryonic Stem Cell Lines are Made" Biology Animation Library :: Dolan DNA Learning Center Stem Cell Animation

14. Essay #2 (cont.) SOURCES Umbilical cord blood Fetal tissue Adult bone marrow Embryonic stem cells

15. Essay #2 (cont.) PROS treat disorders like spinal damage, Parkinson’s disease, leukemia Make heart and nerve tissue in the lab

16. Essay #2 CONS Use embryos (kill them) Click on Creating Stem Cells Click on Creating Stem Cells Don’t have a lot of success yet Who funds it (private v. government)

17. 1. Sexual and Asexual ASEXUAL One parent Two Identical offspring SEXUAL Two parents 4 different offspring

18. 2. Chromatin, chromosomes, chromatids (all DNA + protein) Interphase – loose chromatin Prophase –tightly coiled sister chromatids form through metaphase Anaphase + Telophase –sister chromatids separate to single chromosomes

20. 3. Nucleosomes and Histones 8 histone proteins are wrapped with chromosomes to tightly coil into chromatids Histones + chromosomes = nucleosome DNA packaging, 3D animation with advanced narration and labels :: Dolan DNA Learning CenterDNA packaging, 3D animation with advanced narration and labels :: Dolan DNA Learning Center

21. 4. Asexual Reproduction Prokaryotes (no nucleus) Binary fission Eukaryotes (nucleus) mitosis

22. 5. Phases of Mitosis PMAT Prophase Metaphase Anaphase Telophase

23. 6. Nuclear Envelope Changes Prophase = nuclear envelope dissolves Telophase = nuclear envelope reforms How could you tell them apart?

24. 7. Diff Cytokinesis = Division of the cytoplasm Mitosis = Division of nucleus

25. 8. Cytokinesis Animal Cells Cleavage furrow Plant Cells Cell Plate

26. 9. G1+ S + G2 = Interphase G 1 = organelle growth (mitochondrion, chloroplasts), and growth of cell S = DNA synthesis (replication) G 2 = centriole and spindle growth, and growth of cell

27. 10. Locate on a dividing cell: Chromatids Centrioles Centromeres Spindle fibers Asters

28. 10. Locate on a dividing cell: Chromatids Centromeres Centrioles Spindle fibers Asters

29. centrioles Asters Spindle fibers chromatids centromeres

30. 11. What makes chromatids move to poles? Contraction of spindle fibers spindle contraction videosspindle contraction videos

31. 12. What are cyclins (and Cdk’s)? Protein regulators of the cell cycle

32. 13. Cells Dividing A lot Blood Skin Digestive tract Not after formed Nerve Muscle

33. 13. B Cancer Cells Cancer cells due to an abnormal cell cycle Cells grow abnormally and do not stop, even if there are too many Breast cancer cells

34. What phase? Chromatin thickens? Prophase Nuclear envelope disappears Prophase Nuclear envelope reappears telophase

35. What phase? Centrioles move to opposite poles Prophase Spindle fibers form Prophase Cell plate forms Cytokinesis/Telophase

36. Which phase? Chromosomes line up at the equator metaphase Cytoplasm divides Cytokinesis/Telophase Nucleoli break down Prophase Nucleoli reform Telophase

37. 15. As the cell increases in size The surface area to volume ratio decreases

38. 16. Why do cells divide? cell membrane could not keep up with bringing in enough oxygen/nutrients DNA can’t keep up

39. 17. How many chromosomes Are in each human body cell? 46

40. 18. How many times is the reduction In length of the chromatid than it is in the chromosome form? 10,000 times

41. 19. A cell spends what % of time in interphase? 90%

42. 20. What is the purpose of p53? It is the tumor suppressor gene. p53 animation + Rediscovering Biology - Animation Archive p53 animationRediscovering Biology - Animation Archive It checks that the DNA is OK. If not, it repairs it or kills the cell. IF it is faulty, it leads to a lot of cancer.

43. 21. How does a cell respond to growth When it comes in contact with other cells? Stops growing