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Center for Neural Science
Perception and Memory in the Medial temporal Lobe: Insights from Anatomy and Physiology Wendy A. Suzuki Center for Neural Science New York University MDRS Chapel Hill, NC 9/25/09
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Talk Outline Neuroanatomy of the PRC and area TE
Physiology of the PRC and area TE Future experiments
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Ventral View of Macaque Monkey Brain
TE PH PR ER rs
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Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal
30-60% 18-29% 5-17% <5% DG HPC Sub Entorhinal 24/25/32 Pi Ia Id Ig Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal Lobe V4 23/29/30 7a/LIP STSd STG TE STSv TEO 11/12 46 13 Perirhinal Parahippocampal Suzuki and Amaral, 1994
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Cortical Inputs to the Perirhinal Cortex
TE/TEO 63% STSd 6% TF/TH 25% Insula 2% Frontal lobe 2% Cingulate/Retrosplenial <1% V4 2% Perirhinal Cortex
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Cortical Inputs to Area TE
Dorsal area TE V4/TEO Frontal area 8 and 45 TF Orbital areas 11 and 13 Perirhinal Parietal (LIPd) Area TE
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Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal
30-60% 18-29% 5-17% <5% DG HPC Sub Entorhinal 24/25/32 Pi Ia Id Ig Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal Lobe V4 23/29/30 7a/LIP STSd STG TE STSv TEO 11/12 46 13 Perirhinal Parahippocampal Suzuki and Amaral, 1994
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What about the cytoarchitectonic features of these areas?
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Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal
30-60% 18-29% 5-17% <5% DG HPC Sub Entorhinal 24/25/32 Pi Ia Id Ig Frontal Lobe Temporal Lobe Insular Cortex Cingulate Gyrus Parietal Lobe V4 23/29/30 7a/LIP STSd STG TE STSv TEO 11/12 46 13 Perirhinal Parahippocampal Suzuki and Amaral, 1994
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Talk Outline Neuroanatomy of the PRC and area TE
Physiology of the PRC and area TE Future experiments
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Pair Coding response Individual cell responses in area 36
Naya et al., 2003
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Behavioral Learning Curve and Delay Activity Over Time to Scene 653
1 Response (Spikes/Sec) -10 10 20 30 40 50 Baseline Activity 0.8 0.6 Probability Correct 0.4 0.2 10 20 30 40 50 C Trials Wirth et al., 2003
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Object-Place Association Task
Fixation 500ms Cue Delay 700ms Early Late Reward ITI 2000ms + Bar Release Period Early Late + Object 1 Object 2 Place 1 Place 2 Wirth et al, 2009
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Conclusions: Pair coding neurons are built in the perirhinal cortex from the sensory input from area TE.
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Talk Outline Neuroanatomy of the PRC and area TE
Physiology of the PRC and area TE Future experiments
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Experiments?
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