1. H MRI Marker Active MRI Stents & Vena Cava Filter -brief introduction- Andreas Melzer University of Applied Sciences Gelsenkirchen Institute for Innovative Technologies and Management in Medicine, INSITE med. & Biophan Europe GmbH amelzer@biophan.com

2. H MR Guided Catheterization MR Tip Tracking, MR endovascular imaging B G MR-signal resonator coil MRI Visualization of Catheters and Guide Wires Resonator technology can be applied to catheters and guide wires and used without wiring to the MRI Scanner which eliminates risk of heating.

3. H Resonators on Laparoscopes and Neuroendoscopes 5 mm Endoscope, Olympus, with „wire less“ Tip tracking coil „aMRIs“ Positive contrast display of endoscopes for MR localization and automatically aligned slice orientation Laparoscopic MR guided RF tumor ablation A. Melzer. M. Wendt, J. Duerk, J Lewin, CWRU, Cleveland 1998 Coils MRI Guided Neuroendoscopy, A. Melzer, Chinzei, R.Kikinis, F Jolesz BWH, Harvard, Boston 1999

4. H Balloon expandable aMRIs in different Diameter 5 mm 6 mm 7 mm 8 mm 9 mm 10 mm

5. H Self expanding resonant Nitinol Stent 1.5 Tesla Siemens Magnetom Vison fl2d TR300 TE6 FoV150sq256sq FA40 SL3 AC2 1T5, 0.9 % NaCl- water 0,2 mmol Magnevist/l fr = 66,6 MHz, Q = 6,2 2002 In cooperation with Admedes, (ex Euroflex Schüssler, Pforzheim)

6. H MR guided aMRIs Implantation Experiments in co-operation with: Dept. of Radiology, University Frankfurt, Germany,1.5 Tesla Siemens Resonant Marker proximal and distal to the crimped stent Stent after expansion and partial withdrawal of the balloon catheter PC controlled blood flow Vascular phantom

7. H aMRIs Evaluation In stent imaging intraluminal substrate In stent imaging intraluminal substrate Simulation of intimal hyperplasia (aortic wall) and liquid Simulation of intimal hyperplasia (aortic wall) and liquid

8. H aMRIs Evaluation In stent imaging: intraluminal substrate depiction In stent imaging: intraluminal substrate depiction Thrombus: clotted and liquid blood Thrombus: clotted and liquid blood aMRIs thrombus, TR=300ms, TE=6ms, FA=40°, transversal Tesla, Philips NT, head coil,

9. H MR Guided VCF Implantation and explantation Vascular Phantom with simulation of venous flow in 1.5 Tesla, Siemens Magnetom Vision, flash 2D GRE

10. H Active MRI Vena Cava Filter Open VCF without thrombus Experiments at Dept. of Radiology, University Aachen, Germany, 1. 5 Tesla Philips NT, Approval of MRI imaging of Thrombus capture „in vitro“ with fresh blot Clotted VCF with thrombus

11. H Nitinol aMRI Vena Cava Filter Laser cut active MRI VCF with biocompatible inductivity and capacity through micro structured coatings Laser cut active MRI VCF with biocompatible inductivity and capacity through micro structured coatings Delivery catheter with resonant Marker Delivery catheter with resonant Marker fresh human blood thrombus imaging fresh human blood thrombus imaging 1.0 Tesla Siemens Harmony Signal intensity profile, 1.0 Tesla Siemens Harmony 2002 In cooperation with Admedes, (ex Euroflex Schüssler, Pforzheim) Delivery system Fresh thrombus

12. H 1st animal trial Laser Cut VCF RWTH Aachen Drs. Spüntrup and Bücker RWTH Aachen Drs. Spüntrup and Bücker

13. H 1st animal trial Laser Cut VCF RWTH Aachen Drs. Spüntrup and Bücker RWTH Aachen Drs. Spüntrup and Bücker

14. H 1st animal trial Laser Cut VCF RWTH Aachen Drs. Spüntrup and Bücker RWTH Aachen Drs. Spüntrup and Bücker

15. H 1st animal trial Laser Cut VCF RWTH Aachen Drs. Spüntrup and Bücker RWTH Aachen Drs. Spüntrup and Bücker

16. H 1st animal trial Laser Cut VCF RWTH Aachen Drs. Spüntrup and Bücker RWTH Aachen Drs. Spüntrup and Bücker

17. H 1st animal trial Laser Cut VCF RWTH Aachen Drs. Spüntrup and Bücker RWTH Aachen Drs. Spüntrup and Bücker

18. H 1st animal trial Laser Cut VCF RWTH Aachen Drs. Spüntrup and Bücker RWTH Aachen Drs. Spüntrup and Bücker

19. H 1st animal trial Laser Cut VCF RWTH Aachen Drs. Spüntrup and Bücker RWTH Aachen Drs. Spüntrup and Bücker

20. H Summary Biophan Europe’s proprietary aMRIs technology provides a large platform to improve imaging of vascular and other implants as well as interventional devices during MRI guided vascular and non vascular interventions –www.amris.dewww.amris.de Biophan is working on a variety of proprietary technologies to avoid the risk of pacing lead heating and voltage induction to improve safety of cardiac pacemaker an other stimulation devices –www.biophan.comwww.biophan.com