1. The Microcirculation
Figure 16-1; Guyton and Hall

2. Structure of Capillary Wall
Figure 16-2; Guyton and Hall

3. Interstitium and Interstitial Fluid
Figure 16-4; Guyton and Hall

4. Determinants of Net Fluid Movement across Capillaries
Figure 16-5; Guyton and Hall
Capillary hydrostatic pressure (Pc)-tends to force fluid outward through the capillary membrane.
Interstitial fluid pressure (Pif)- opposes filtration when value is positive.

5. Determinants of Net Fluid Movement across Capillaries
Figure 16-5; Guyton and Hall
Plasma colloid osmotic pressure ( c)- opposes filtration causing osmosis of water inward through the membrane
Interstitial fluid colloid pressure ( if) promotes filtration by causing osmosis of fluid outward through the membrane
NP = Pc -  c - Pif +  if

6. Plasma Proteins and Colloid Osmotic Pressure
75% of the total colloid osmotic pressure of plasma results from the presence of albumin and 25% is due to globulins.
gm/dl p(mmHg)
Albumin
Globulins
Fibrinogen
Total

7. Determinants of Net Fluid Movement Across Capillaries
Figure 16-5; Guyton and Hall
Filtration rate = net filtration pressure (NFP) multiplied by the filtration coefficient
Filtration coefficient (Kf) is a product of surface area times the hydraulic conductivity of membrane

8. Forces Causing Filtration at the Arteriole End of the Capillary
mmHg
Forces tending to move fluid outward:
Capillary pressure 30
Negative interstitial free fluid pressure 3
Interstitial fluid colloid osmotic pressure 8
TOTAL OUTWARD FORCE
Forces tending to move fluid inward:
Plasma colloid osmotic pressure 28
TOTAL INWARD FORCE
Summation of forces:
Outward
Inward
NET OUTWARD FORCE

9. Forces Causing Reabsorption at the Venous End of the Capillary
mmHg
Forces tending to move fluid inward:
Plasma colloid osmotic pressure 28
TOTAL INWARD FORCE
Forces tending to move fluid outward:
Capillary pressure 10
Negative interstitial free fluid pressure
Interstitial fluid colloid osmotic pressure
TOTAL OUTWARD FORCE 21
Summation of forces:
Outward 21
Inward 28
NET INWARD FORCE 7

10. Net Starling Forces in Capillaries
mmHg
Mean forces tending to move fluid outward: Mean Capillary pressure 17.3 Negative interstitial free fluid pressure 3.0 Interstitial fluid colloid osmotic pressure 8.0 TOTAL OUTWARD FORCE 28.3 Mean force tending to move fluid inward: Plasma colloid osmotic pressure 28.0 TOTAL INWARD FORCE 28.0 Summation of mean forces: Outward 28.3 Inward 28.0 NET OUTWARD FORCE 0.3

11. Net Starling Forces in Capillaries
Figure opener; Guyton and Hall
Net filtration pressure of .3 mmHg which causes a net filtration rate of 2ml/min for entire body.

12. Question Utilizing the data below, calculate the rate of net fluid
movement across the capillary wall:
Pressures (in mmHg)
Plasma colloid osmotic = 20
Capillary hydrostatic = 20
Venous hydrostatic = 5
Arterial = 80
Interstitial hydrostatic = -5
Interstitial colloid osmotic = 5
Filtration coefficient = 10 ml/min/mmHg
a. 0 ml/min d. 100 ml/min (Reabsorption)
b. 10 ml/min (Filtration) e. 10 ml/min (Reabsorption)
c. 100 ml/min (Filtration)

13. Lymphatic System

14. Determinants of Lymph Flow
The degree of activity of the lymphatic pump
smooth muscle filaments in lymph vessel cause them to contract
external compression also contributes to lymphatic pumping
Figure 16-11; Guyton and Hall

15. Determinants of Lymph Flow
Interstitial fluid hydrostatic pressure
Lymph Flow
Figure 16-9; Guyton and Hall
Figure 16-10; Guyton and Hall