1. The Relationship between Frailty and Osteoporosis in Women over 70 Y. Oliel*, T. Resnick*, S. Sternberg**, J. Menczel***, & A. Woloski-Wruble* * Hadassah and Hebrew University School of Nursing in the Faculty of Medicine, Jerusalem, Israel ** Maccabi Health Services, Jerusalem, Israel *** Herzog Hospital, Jerusalem, Israel Objective To determine the relationship between osteoporosis and frailty in Israeli women over the age of 70. Results Ahmed, N., Mandel, R., & Fain, M. (2006). Frailty: An emerging geriatric syndrome. The American Journal of Medicine, 120, 748-753 Fried, L. P.,et al. (2001). Frailty in older adults: Evidence for a phenotype. The Journals of Gerontology, 56A, 146- 156. Fried, L.P., & Walston, J. (2003). Frailty and failure to thrive. In W.R. Hazzard, J.P. Blass, W.H. Ettinger, Jr., J.B. Halter, & J. Ouslander (Eds.), Principles of geriatric medicine and gerontology (pp. 1487-1502). New York: McGraw Hill Publishers. Health Ministry (Israel) 2003. בריאות הקשישים בקהילה (Health status of community dwelling elders). Iecovich. E., & Carmel, S. (2010). Health and functional status and utilization of health care services among holocaust survivors and their counterparts in Israel. Archives of Gerontology and Geriatrics, 51, 304-308. Marcus, E.L., & Menczel, J. (2007). Higher prevalence of osteoporosis among female Holocaust survivors. Osteoporosis International, 18, 1501-1506. Rolland, Y., et al. (2008) Frailty, osteoporosis and hip fracture: Causes, consequences and therapeutic perspectives. The Journal of Nutrition, Health & Aging, 12 (5), 335-346. Saliba, D., et al. (2001). The vulnerable elders survey: A tool for identifying vulnerable older people in the community. The Journal of the American Geriatric Society, 49, 1691-1699. References DESIGN: Descriptive correlational study. SETTING: Community dwelling Israeli women. INSTRUMENTS: Frailty: Cardiovascular Health Study (CHS) Index (Fried et al., 2001) Vulnerable Elders Survey (VES-13) Questionnaire (Saliba et al., 2001) Osteoporosis: bone mineral density (BMD), measured by dual energy X-ray absorptiometry (DXA) Methods and Materials Cycle of Frailty ( Ahmed et al., 2006 ) Osteoporosis in women This study did not support a direct association between frailty and osteoporosis, though it provides important insight into the challenges related to conducting research with this age group. The suggestion of an association between frailty and osteoporosis, which exists only after controlling for Holocaust survival and the self-reported number of years since start of menopause, may be worthwhile investigating with a larger population sample allowing stratification by these variables. As noted in the literature (Iecovich & Carmel, 2010; Marcus & Menczel, 2007), women who survived the Holocaust are at increased risk for osteoporosis. The suggested connection with frailty only strengthens the need for counseling and follow-up of this group. The present study is part of an ongoing longitudinal study that attempts to follow older women and determine the relationship between osteoporosis and frailty. Discussion Main Variables Osteoporosis Diminished bone mass, disruption of microscopic bone structure, and bone fragility. Prevalence in Israel - more than 150 thousand women, aged 65 years or older (Israel Health Ministry, 2003) Sign of vulnerability and may be a good marker for frailty (Rolland et al., 2008) Frailty Connected to molecular changes in the cells and characterized by a syndrome of shrinking (sarcopenia and weight loss), weakness, and exhaustion. Prevalence: 10-25% of the elderly; up to 45% in those over 85 years of age (Fried & Walston, 2003) The pre-frail are at high risk of developing the full frailty syndrome (Fried et al., 2001) Almost half of the subjects reported being previously diagnosed with osteoporosis. A correlation of 0.61 (p<.01) was found between the two scales measuring frailty. No direct association was found between frailty and osteoporosis. A convenience sample of women, from one of the health care organizations N = 137 Mean age - 76 years (range 70-95) Most reported good financial status Most reported 10th grade or higher education Average cognitive and functional status - at the upper limits Sample characteristics After adjusting for Holocaust survival and self- reported number of years since the start of menopause, it was found that the CHS Index frail subjects, versus the normal and pre-frail subjects, had a fourfold increase for the risk of osteoporosis (OR = 0.25, 95% CI [0.07, 0.91])