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(Gram negative rods enteric tract)Enterobacteriaceae I (Gram negative rods enteric tract) Lecture 34 Faculty: Dr. Alvin Fox
Key Words Opportunistic diseases ShigellaDiarrhea Bacillary dysentery Dysentery Shiga toxin Urinary tract infections Salmonella enteritidis Pili Salmonellosis Lactose positive/negative Salmonella cholerae-suis Enterohemorrhagic E. coli Salmonella typhi - Vero toxin (Shiga-like) - Typhoid - Hemolysin Vi Enterotoxigenic E. coli Yersinia entercolitica - Heat stable toxin Vibrio cholerae - Heat labile toxin Choleragen (cholera toxin) Enteropathogenic E. coli Campylobacter jejuni Enteroaggregative E. coli Helicobacter pylori Enteroinvasive E. coli
Opportunistic diseases -Enterobacteriaceaesepticemia, pneumonia, meningitis urinary tract infections Citrobacter Enterobacter Escherichia Hafnia Morganella Providencia Serratia
Enterobacteriaceae gastrointestinal diseases Escherichia coliSalmonella Shigella Yersinia entercolitica
Reiter's syndrome Histocompatibility antigen (HLA) B27Enterobacteriaceae Salmonella Shigella Yersinia Non-Enterobacteriaceae Campylobacter Chlamydia
Enterobacteriaceae community acquired otherwise healthy peopleKlebsiella pneumoniae respiratory diseases prominent capsule urinary tract infection fecal contamination E. coli Proteus urease (degrades urea) alkaline urine
E. coli fimbriae Type 1 mannose P galactose glycolipids glycoproteins
Enterobacteriaceae gram negative facultative anaerobic rods– oxidase negative (no cytochrome oxidase)
Feces E. coli lactose positive not usually identifiedlactose positive sp. common, healthy intestine Shigella, Salmonella,Yersinia lactose negative identified
Enterobacteriaceae other sites identified biochemically
Serotypes reference laboratory antigens O (lipopolysaccharide)H (flagellar) K (capsular)
Diarrhea (watery feces) and Dysentery (blood in stools)
Caption: E. coli Escherichia coli
Escherichia coli E. coli and Shigella genetically very similarseparated for historical reasons overlap in pathogenesis
Enterohemorrhagic E. coliUsually O157:H7 Transmission electron micrograph Flagella
Transmission – meat products or sewage-contaminated vegetablesHemorrhagic Bloody dysentery copious diarrhea few leukocytes afebrile hemolytic-uremic syndrome hemolytic anemia thrombocytopenia (low platelets) kidney failure
Enterohemorrhagic E. coliVero toxin “shiga-like toxin” Hemolysins
Enterotoxigenic E. colidiarrhea like cholera milder travellers diarrhea
Enterotoxigenic E. coliHeat labile toxin like choleragen Adenyl cyclase activated cyclic AMP secretion water/ions Heat stable toxin Guanylate cyclase activated cyclic GMP uptake water/ions
Enteropathogenic E. colidestruction of surface microvilli fever diarrhea vomiting nausea non-bloody stools (not generally seen as dysentery) Gut lumen
Enteroaggregative Mucus biofilm inhibits fluid absorption DiarrheaBrick-like bacterial aggregates - cell surfaces Mucus biofilm inhibits fluid absorption Diarrhea
Enteroinvasive E. coli (EIEC )Dysentery - resembles shigellosis Gut lumen
Treatment -gastrointestinal diseasefluid replacement antibiotics not used usually unless systemic e.g. hemolytic-uremia syndrome
Shigella Modified from Fig, Dennis Kunkel
Shigella S. flexneri, S. boydii, S. sonnei, S. dysenteriaebacillary dysentery shigellosis bloody feces intestinal pain pus
Shigellosis within 2-3 days epithelial cell damage Gut lumen
Shiga toxin enterotoxic cytotoxic inhibits protein synthesislysing 28S rRNA
Shigellosis man only "reservoir" mostly young childrenfecal to oral contact children to adults transmitted by adult food handlers unwashed hands
Treating shigellosis manage dehydrationpatients respond to antibiotics disease duration diminished
Salmonella  Caption: Salmonella typhi - Gram-negative, enteric, rod prokaryote (dividing); causes typhoid fever. Magnification*: x5,530 Type: SEM Keywords: 96430B.TIF bacilli bacillus bacteria bacterial pathogen bacterium division Gram-negative human disease infection prokaryote rod Salmonella typhi typhoid fever enteric bacterial pathogen intestinal tract infection SEM |
Salmonella 2000 antigenic "types” genetically single speciesS. enterica disease category S. enteritidis many serotypes S. cholerae-suis S. typhi
Salmonellosis S. enteritidis the common salmonella infectionpoultry, eggs no human reservoir Gastroenteritis nausea vomiting non-bloody stool self-limiting (2 - 5 days)
Control of salmonellosisMonitoring of food in the US is limited microbiology is difficult Regulation is not optimal Chickens are not vaccinated in US UK, salmonellosis largely erradicated
Salmonellosis uncomplicated cases (the vast majority)Gut lumen uncomplicated cases (the vast majority) antibiotic therapy not useful
S. cholerae-suis much less common septicemiaantibiotic therapy essential
Gasrtointestinal bacterial infections Gastroentritis *Is the most common form of acute gastrointestinal infection, causing diarrhea with or without vomiting.
Pathogenic Enteric Bacteria I
Lecture 17: Microbial diseases of the digestive system Edith Porter, M.D. 1.
Enterobacteriaceae Chapter 31. Introduction “Enteric Bacteria” Gram-negative rods Ubiquitous Cause 30%-35% of all septicemias, more than 70% of.
Chapter 16 - Enterobacteriaceae
Bacteria that cause diarrhea and dysentery
Gram Negative Rods of the Enteric Tract
Gastroenteritis Inflammation of stomach or intestines –Inhibits nutrient absorption and excessive H 2 O and electrolyte loss Bacterial Viral Parasites.
The central market in Bangalore, India. Food safety standards barely exist in most of the developing world.
FOOD BORNE DISEASES Lecture Group A
MICROBIAL DISEASES OF THE DIGESTIVE SYSTEM. MOUTH Over 300 types of bacteria Dental caries Periodontal disease –Gingivitis –Periodontitis.
Enterobacteriaceae 미생물학교실 권 형 주.
Clinical Microbiology ( MLCM- 201) Prof. Dr. Ebtisam.F. El Ghazzawi Medical Research Institute (MRI) Alexandria University.
Microbial Diseases of the Digestive System
DIARRHOEAL DISEASES Causes of Over-indulgence in Chemical Long-term antibiotic Viral causes: # Rotavirus # Norwalk.
Gram-negative rods: Enterobacteriaceae Part II
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