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Osler Institute – Pathology Board Review: Electron Microscopy EM of Tumors and Tumor-like Entities.

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Presentation on theme: "Osler Institute – Pathology Board Review: Electron Microscopy EM of Tumors and Tumor-like Entities."— Presentation transcript:

1 Osler Institute – Pathology Board Review: Electron Microscopy EM of Tumors and Tumor-like Entities

2 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Oncocytoma Salivary gland Parotid Kidney

3 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Oncocytoma Pleomorphic mitochondria Lamelliform (plate like) mitochondrial cristae Dense bodies in mitochondria

4 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Plasmacytoma Nuclei Marginated heterochromatin Prominent profiles of rough endoplasmic reticulum Immunoglobulin inclusions in RER and nucleus

5 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Renal Cell Carcinoma (conventional type) Long microvilli Glycogen Lipid droplets

6 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Renal Cell Carcinoma Chromophobe Type Microvesicles Hale’s colloidal iron positive Papillary (chromophil) Type Abundant mitochondria

7 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Seminoma Wandering, ropy, nucleolus Finely dispersed heterochromatin Inconspicuous organelles Intercellular junctions

8 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Squamous cell carcinoma Desmosomes Tonofilament bundles

9 Electron Microscopy - Osler Institute Pathology Board Review Small Round Cell Tumors

10 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Ewings Sarcoma Dispersed heterochromatin Small nucleolus

11 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Ewings Sarcoma Large pools of glycogen

12 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Rhabdomyosarcoma Actin-myosin filaments with Z- band Primitive sarcomeres

13 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Rhabdomyosarcoma Ribosome-filament complexes Small primitive junctions External lamina

14 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Neuroblastoma Cell processes Secretory granules Microtubules Neurofilaments

15 Electron Microscopy - Osler Institute Pathology Board Review Neoplasms Small Round Cell Tumors Lymphoma (Follicular Center Cell) No cell junctions


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