Presentation is loading. Please wait.

Presentation is loading. Please wait.

Bcl-2 and its Role in Cancer. Mitochondria in the Cell

Published byTylor Capwell Modified over 9 years ago

Similar presentations

Presentation on theme: "Bcl-2 and its Role in Cancer. Mitochondria in the Cell"— Presentation transcript:

1 Bcl-2 and its Role in Cancer

2 Mitochondria in the Cell http://micro.magnet.fsu.edu/cells/mitochondria/images/mitochondriafigure1.jpg

3 Cytochrome C’s Dual Functionality Protein that carries electrons in electron transport chain between mitochondrial membranes BUT released into cytosol, triggers apoptosis http://upload.wikimedia.org/wikipedia/commons/thumb/b/ba/Cytochrome_C.png/250px- Cytochrome_C.png

4 Bcl-2 family – apoptosis regulators http://www.cancer.gov/cancertopics/understandingcancer/targetedtherapies/lympho ma_htmlcourse/page3

5 Stress signal (DNA damage, heat shock) Pro-apoptotic members activated Cytochrome c release via MOMP Cytochrome c complexes with ATP and Apaf-1 (enzyme) Caspase-9 activated, then forms apoptosome with previous complex Caspase cascade to apoptosis http://www.reading.ac.uk/nitricoxide/intro/apoptosis/mito2.jpg Apoptosis Pathway

6 http://openi.nlm.nih.gov/detailedresult.php?img=2132464_JCB.amling5g&req=4 Viable, but smaller Half die by 6 weeks Smaller kidneys Skeletal development Immune failure Bcl-2 Knockout Mice

7 https://encrypted- tbn3.gstatic.com/images?q=tbn:ANd9GcTkoz4iPsXeDUTi1dbV1wzIQsD8sDB7HqkRJaxih9U4 UWe9Cusd-A Non- Hodgkin Lymphoma

8 http://www.sciencedirect.com/science/article/pii/S0167488903001885 Bcl-2 Translocations Found in Cancer

9 http://www.cancer.gov/cancertopics/understandingcancer/targetedtherapies/lymphoma_ htmlcourse/page3 Overexpression of Bcl-2 on the Outer Membrane of Mitochondria

10 Inhibiting Bcl-2 http://www.cancer.gov/images/targetedtherapies/lymphoma/m4s3c_1.jpg

11 http://www.cancer.gov/PublishedContent/Images/images/targetedtherapies/lymphoma/ m4s3c_3.jpg Potential Therapeutic Undergoing Clinical Trials

12 Sources http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2 132464/ http://www.scq.ubc.ca/apoptosis/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3 220196/pdf/iep_79.pdf http://www.cancer.gov/cancertopics/understandi ngcancer/targetedtherapies/lymphoma_htmlcour se http://www.sciencedirect.com/science/article/pii /S0167488903001885

Download ppt "Bcl-2 and its Role in Cancer. Mitochondria in the Cell"

Similar presentations

Apoptosis By Douglas R. Green

Apoptosis By Douglas R. Green
Caspases in p75-mediated Neuronal Death Pathway. Cell Death Necrosis –Response to disease –Inflammatory Response Apoptosis –Present in Developing Tissue.

Caspases in p75-mediated Neuronal Death Pathway. Cell Death Necrosis –Response to disease –Inflammatory Response Apoptosis –Present in Developing Tissue.
APOPTOSIS In the human body about 100,000 cells are produced every second by mitosis and a similar number die by apoptosis !!!

APOPTOSIS In the human body about 100,000 cells are produced every second by mitosis and a similar number die by apoptosis !!!
Mechanisms of Bcl-2 in Programmed Cell Death Laura Beth Hill St. Edward’s University.

Mechanisms of Bcl-2 in Programmed Cell Death Laura Beth Hill St. Edward’s University.
Mechanisms of Bcl-2 in Programmed Cell Death Laura Beth Hill St. Edward’s University.

Mechanisms of Bcl-2 in Programmed Cell Death Laura Beth Hill St. Edward’s University.
Signaling to PROGRAM cell death (Apoptosis) Apoptosis is a cell mechanism used to eliminate cells that are unnecessary to or that contain mutations that.

Signaling to PROGRAM cell death (Apoptosis) Apoptosis is a cell mechanism used to eliminate cells that are unnecessary to or that contain mutations that.
Chap. 21 Stem Cells, Cell Asymmetry, and Cell Death Topics Cell Death and Its Regulation Goals Learn the basic mechanism of apoptosis and its regulation.

Chap. 21 Stem Cells, Cell Asymmetry, and Cell Death Topics Cell Death and Its Regulation Goals Learn the basic mechanism of apoptosis and its regulation.
Apoptosis By Dr Abiodun Mark .A.

Apoptosis By Dr Abiodun Mark .A.
Big lessons from little worms

Big lessons from little worms
Chlamydiae Obligate intracellular pathogens. Obligate intracellular pathogens. Acute and/or persistent infections. Acute and/or persistent infections.

Chlamydiae Obligate intracellular pathogens. Obligate intracellular pathogens. Acute and/or persistent infections. Acute and/or persistent infections.
Lecture 19 Homework Review Apoptosis and Cancer Next Two Lectures: Cell-Cell Interactions/Tissues Early Development and Stem Cells For Exam III- You are.

Lecture 19 Homework Review Apoptosis and Cancer Next Two Lectures: Cell-Cell Interactions/Tissues Early Development and Stem Cells For Exam III- You are.
APOPTOSIS “Cell Death” By Brian Abadie, Emily Anderson, andJohn Ramsey.

APOPTOSIS “Cell Death” By Brian Abadie, Emily Anderson, andJohn Ramsey.
The Role of Bcl-2 in Apoptosis and Cancer Eddie Alcorn.

The Role of Bcl-2 in Apoptosis and Cancer Eddie Alcorn.
Bcl-2 family There are three classes of Bcl-2 according to their domains and apoptotic effect: – Anti-apoptotic proteins contain four specific domains.

Bcl-2 family There are three classes of Bcl-2 according to their domains and apoptotic effect: – Anti-apoptotic proteins contain four specific domains.
Apoptosis is only one form of programmed cell death.

Apoptosis is only one form of programmed cell death.
Lecture 11: Cell proliferation, differentiation, and death Dr. Mamoun Ahram Faculty of Medicine Second year, Second semester, 2014-2014 Principles of.

Lecture 11: Cell proliferation, differentiation, and death Dr. Mamoun Ahram Faculty of Medicine Second year, Second semester, Principles of.
Apoptosis (Programmed Cell Death). Apoptosis vs Necrosis Level of stress, change in environment stress apoptosisnecrosis.

Apoptosis (Programmed Cell Death). Apoptosis vs Necrosis Level of stress, change in environment stress apoptosisnecrosis.
1. p53 Structure, Function and Therapeutic Applications Provider: Dr.Davood Nourabadi(PhD,medical physiology) mdphysiology.persianblog.ir.

1. p53 Structure, Function and Therapeutic Applications Provider: Dr.Davood Nourabadi(PhD,medical physiology) mdphysiology.persianblog.ir.
Death and Rescue Regulation of cardiac myocyte cell death Lin GH.

Death and Rescue Regulation of cardiac myocyte cell death Lin GH.
Programmed Cell Death. Why do some cells need to die? To accomplish morphogenetic ends, eg. Separation of fingers during embryogenesis of the hand To.

Programmed Cell Death. Why do some cells need to die? To accomplish morphogenetic ends, eg. Separation of fingers during embryogenesis of the hand To.

Similar presentations

Ads by Google