Presentation on theme: "Kevin S. Hughes, MD, FACS Co-Director, Avon Comprehensive Breast Evaluation Center Massachusetts General Hospital Associate Professor of Surgery Harvard."— Presentation transcript:
Kevin S. Hughes, MD, FACS Co-Director, Avon Comprehensive Breast Evaluation Center Massachusetts General Hospital Associate Professor of Surgery Harvard Medical School Surgeon The Newton-Wellesley Hospital Breast Center Is Post-Lumpectomy Radiation Necessary in Older Patients?
1.9 cm, ER+, clinical N0 Cancer Lumpectomy Plus Radiation/Boost Tamoxifen Sentinel Node Chemotherapy BRCA testing
1.9 cm, ER+, clinical N0 Cancer Lumpectomy Plus Radiation/Boost Tamoxifen Sentinel Node Chemotherapy BRCA testing Lumpectomy Plus Radiation/Boost Tamoxifen/AI Sentinel Node Chemotherapy BRCA testing
CALGB 9343 Comparison of Lumpectomy Plus Tamoxifen With and Without Irradiation in Women 70 or Older with Clinical Stage I, ER+ Breast Carcinoma Kevin S. Hughes, Lauren A. Schnaper, Constance Cirrincione, Donald Berry, Beryl McCormick, Hyman B. Muss, Clifford Hudis, Eric Winer, Barbara L. Smith Cancer and Leukemia Group B Radiation Therapy Oncology Group Eastern Cooperative Oncology Group
CALGB 9343 ELIGIBILITY Age 70 ELIGIBILITY Age 70Clinically Node Negative Lumpectomy, Negative Margin Tumor size 2 cm Node Negative Lumpectomy, Negative Margin Tumor size 2 cm ER Positive or Indeterminate STRATIFICATION Age < 75 75 Axillary Dissection Yes No RadiationTamoxifen Tamoxifen RANDOMIZERANDOMIZERANDOMIZERANDOMIZE
CALGB 9343 Opened July 15, 1994 Closed February 26, 1999 647 patients –Eligible 631 –Ineligible 5 –Canceled/Never treated 11 Median follow-up 12 years
Patient characteristics RT+Tam Tam Total treated 317 319 Age >75 176 (56%)172 (54%) ER Positive308 (97%)310 (97%) Size < 2cm295 (93%)296 (93%) No Ax dissection 200 (63%)203 (64%)
IBTR (Ipsilateral Breast Tumor Recurrence) 91% 98%
Ipsilateral cancer risk 40 and under RT 70 above no RT LCIS
Radiation decreases local recurrence by ~7% Does it do anything else?
Breast Recurrence Less Ultimate Mastectomy Same Second primary cancer Same Distant metastasis Same Death Same Death Other CausesSame Death from breast cancerSame 22 women With modern margins and AI’s, RT will likely have even less benefit CONCLUSION: In older women, the benefits of radiation after lumpectomy are small