1. STUDY UPDATE The Stroke Oxygen Study Summer 2009 Newsletter SOS CO-ORDINATING CENTRE Stroke Research Office North Staffs. Royal Infirmary Princes Road Hartshill Stoke-on-Trent ST4 7LN www.so2s.co.uk Chief Investigator: Dr Christine Roffe Tel: 01782 555877 E-mail: Christine.roffe @northstaffs.nhs.uk Study Co-ordinator: Dr Sarah Pountain Tel: 01782 55875 E-mail: sarah.pountain @northstaffs.nhs.uk Data manager/ Study Administrator: Jackie Richards Tel: 01782 55875 E-mail: jackie.richards @northstaffs.nhs.uk RECRUITMENT Total: 286 (up to 1 st July ‘09)  No. of Active centers : 40  No. of centres awaiting approval: 48  No. of centres expressing an interest: 11 CENTRE RECRUITMENT We are still looking for more centres — should you wish to be involved or know of a prospective centre please contact Sarah Pountain (Study co-ordinator). Dates for the Diary – UK STROKE FORUM 2009 After last years success we will be having a stand at the UK Stroke Forum in Glasgow (1-3 Dec 09). Please visit us on stand 41 Collaborators meeting – we will also be having a collaborators meeting at the UK Stroke Forum on Thursday 3 rd Dec at 8am. We look forward to seeing you there. NEW SITES! Welcome to the following new SOS recruiting sites: Mid Staffordshire Hospital, Royal Bournemouth, Bishop Auckland General Hospital, University Hospital of North Durham, St Helens & Knowsley, Doncaster Royal Infirmary, Medway Hospital, Leighton Hospital, Southend University Hospital, Blackpool Victoria Hospital, University Hospital Aintree, Leeds Teaching Hospital, Wansbeck & North Tyneside Hospitals, Salford Royal Hospital, Norfolk & Norwich University Hospital, Kings College, Macclesfield General Hospital, Barnsley Hospital, Wigan Hospital, Royal Wolverhampton Hospital, South Tyneside General Hospital SO 2 S Acute Stroke Training Days With the NIHR CRN the SOS study ran 2 training days in Birmingham (May) and London (July). The sessions included a clinical background to the study and protocol review, an obtaining consent for the study session – with a researchers experience, a potential problems and clinical benefit of the study. The sessions were interactive to allow lots of discussion and recruitment tips. These were well attended and received positive feedback. Thanks for all who attended.

2. SOS patient recruitment (April ’08 – 1 st July ‘09) To: Ashford & St Peters, Birmingham Heartlands Bishop Auckland Brighton & Sussex Freeman & Royal Victoria Leighton Hospital Royal Bournemouth Royal Liverpool Southend Hospital Royal Sunderland Hospital University Hospital of BirminghamUniversity Hospital of North Durham Yeovil Hospital For recruiting their 1 st SOS patients Recruitment To: Dr Church & team at Uni. Hospital of North Durham Dr Mukerjee & team at Queens, Burton Dr Husain & team at Musgrove Park Dr Dixit & team at Freeman and Royal Victoria For being the highest recruiters in May and June SOS - Hints and Tips NIHSS Dr Roffe presented an update on the SOS study at the SRN conference in Newcastle on the 8-9 th July 2009. During this she discussed the current spread of NIHSS scores recruited into the study. In order to obtain unbiased data she would like to recruit more sever strokes to the study as well as the mild ones. This is an acute stroke trial and Dr Roffe has said “it is important to get a true picture of the use of oxygen treatment for the full range of strokes – from the mild to acute range”. Data entry Many thanks for all your hard work in inputting the data promptly – can we take this opportunity to remind you to complete the week 1 contact details (with a 2 nd contact address) AND to remember to hit submit once the data has been saved.

3. Site Recruitment SitePISiteRecruitment active date(to 1st July 09) Ashford & St Peter's Hospital Dr R Nari22/04/2009 1 Birmingham Heartlands Dr D Sandler22/04/2009 7 Bishop Auckland General Hospital Dr A Mehrzad01/05/2009 1 Brighton & Sussex Uni. Hospital Dr K Ali05/03/2009 12 Countess of Chester Dr K Chatterjee04/02/2009 13 Derriford Hospital Dr A Mohd Nor25/03/2009 1 Freeman Hospital & Royal Victoria Dr A Dixit22/04/2009 9 Leighton Hospital Dr Maity05/06/2009 3 Musgrove Park Hospital Dr M Husain05/03/2009 20 Northampton General Hospital Dr M Blake17/04/2009 2 Queens Burton Dr B Mukerjee02/02/2009 20 Royal Bournemouth Dr D Jenkinson29/04/2009 6 Royal Cornwall Hospital Dr F Harrington23/03/2009 10 Royal Devon & Exeter Dr M James26/01/2009 10 Royal Liverpool Uni. Hospital Dr S Loharuka10/03/2009 2 Royal Preston Hospital Dr S Punekar19/02/2009 2 Southend University Hospital Dr P Guyler23/06/2009 4 St George's Dr B Moynihan16/03/2009 7 Stepping Hill Dr S Krishnamoorthy19/02/2009 14 Sunderland Royal Hospital Prof C Gray22/04/2009 1 Torbay Hospital Dr D Kelly29/01/2009 5 Uni. Hospital Birmingham Dr D Sims16/04/2009 2 Uni. Hospital North Durham Dr C Church01/05/2009 11 Uni. Hospitals of Leicester Dr A K Mistri26/03/2009 3 Uni. Hospital of North Staffs Dr C Roffe22/04/2008 105 Walsgrave Hospital Dr P K Ray19/02/2009 9 West Cumberland Hospital Dr E O Orugun29/01/2009 5 Yeovil District Hospital Dr K Rashed23/02/2009 1