2.  Refining development of device using shape memory polymer foams to non-surgically treat aneurysms.  Developed research at Lawrence Livermore.  Chose Texas A&M Institute for Preclinical Studies (TIPS) because of facilities.

3.  Large animal research facility, founded 2007,  Supports research in medical device development.  Trains students in engineering, science and veterinary medicine.  Facilitates preclinical testing.  1 of 7 labs in the country conducting this research.

4.  Aneurysms are abnormal widening or ballooning of blood vessels.  Prevalent in 5% of the U.S. population.  Not life threatening unless it begins pressing on the brain or ruptures.  30,000 people die or suffer neurological damage from rupture. (Stroke or subarachnoid hemorrhage)  Pre-existing conditions include hypertension, atherosclerosis, head trauma and birth defects.

5. Micro-vascular Clipping (1937) Completely close off with a metal clip to prevent bleeding or rupture protecting nearby brain tissue from damage. Risks: -anesthesia -cut into skull

6. Embolic Coiling, (1990’s )

7.  SMP’s are polymers that remember their shape.  Can be compressed drastically and still retain original shape when acted upon by stimulus.

9. Polymer foam inserted through catheter in its compressed form. Laser light beam is shone through an optical fiber in the catheter. Laser hits the SMP cylinder which expands and plugs the aneurysm as it returns to its original ball shape.

10. Deform at High Temperature (above glass transition temp) Heat above glass transition Cool below glass transition and Unload Shape Fixity Shape Recovery A BBB A DeformCoolUnloadHeat Permanent Shape at High Temp Temporary Shape at Low Temp SMP Deformation Process

11.  Shaped for faster and more complete occlusion of the aneurysm.  Lower and more uniform stresses to the aneurysm wall, thereby decreasing the risk of hemorrhage.  Faster healing time due to structure of foam.

12.  To become familiar with the tools and techniques used in developing a shape memory polymer (SMP) foam plug device for the treatment of cerebral aneurysms from research implementation studies to completed device by modeling the research activities conducted in the biomedical device lab.

13.  Develop 3-D model of an aneurysm.  Create various SMP’s and investigate their properties.  Develop model of SMP foam device.

15. Acrylic SMP

16. Dip coating brass rods for stents

17. Creating 3-D model of aneurysm from MRI to design SMP foam device.

18.  To become familiar with shape memory polymers and other biomaterials their use in medicine and industry.  Incorporate engineering concepts into my biology curriculum.  Relate the real world applications of engineering in biology and other science disciplines.

19.  TAMU E3 Program  National Science Foundation  Nuclear Power Institute  Texas Workforce Commission  Dr. Duncan Maitland  Mr. John Horn