1. Bellwork: Using the codon charts in your notes, fill in the boxes below. **Remember to use mRNA when doing translation**

2. Science Fact of the Day: The world’s termites outweigh the world’s humans 10 to 1.

3. CO: I will identify and evaluate the effects of mutations in DNA
CO: I will identify and evaluate the effects of mutations in DNA. LO: I will write notes. I will read a paragraph and fill in the missing words. I will model DNA mutations.

4. Introduction with Blocks

5. Think about it: What happens if our DNA gets messed up?

6. The Amazing Spiderman

7. Cells sometimes make mistakes when copying their own DNA
Cells sometimes make mistakes when copying their own DNA. These mistakes are called mutations. Mutations are changes in the genetic material.
NOTE: mutations can also be caused by environmental factors like radiation

8. Point Mutations: gene mutations involving changes in one or a few nucleotides - Three types of point mutations are substitutions, insertions, and deletions.

9. Types of Mutations

10. Genetic Mutations: Your Name
Copy the chart below.
Write your name in the first box.
Put a box around each codon.
Fill in the rest of the start by doing the mutation.
Put a box around each codon after the mutation.
Name:
T I F F A N Y J O N E S
Insertion (add a base into the sequence)
T I F F A N Y Z J O N E S
Deletion (take a base away)
Substitution (take out a base and put a different one in its place

11. Frameshift Mutation: a nucleotide is added or deleted
Frameshift Mutation: a nucleotide is added or deleted - the bases are still read in groups of three - those groupings are shifted for every codon that follows.

12. Think-pair-share
Would a frame shift mutation or a point mutation cause a bigger effect in an organism? Why?

14. Do you know of any diseases caused by genetic mutations?

15. Sickle Cell Anemia
These are the sickle-shaped blood cells of someone with sickle cell anemia. Sickle cell anemia is the result of a point mutation, a change in just one nucleotide in the gene for hemoglobin. This mutation causes the hemoglobin in red blood cells to distort to a sickle shape when deoxygenated. The sickle-shaped blood cells clog in the capillaries, cutting off circulation. Having two copies of the mutated genes cause sickle cell anemia, but having just one copy does not, and can actually protect against malaria - an example of how mutations are sometimes beneficial.

16. Color Blindness
Most forms are caused by a point mutation on the X chromosome.
What number do you see? A color blind person won’t see anything. A color deficient person may see the number 35

17. Achondroplasia
This is the most common form of dwarfism. It is caused by a substitution mutation for the gene that codes for bone growth.