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Published byOmari Dobb Modified over 9 years ago
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SONG Hui
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Outline Anticoagulants ( 抗凝 ) Anticoagulants ( 抗凝 ) Thrombolytic agents ( 纤溶 ) Thrombolytic agents ( 纤溶 ) Coagulants ( 促凝 ) Coagulants ( 促凝 ) Anti- Anemia ( 扶贫 ) Anti- Anemia ( 扶贫 ) White cells stimulants ( 增白 ) White cells stimulants ( 增白 ) Blood volume increasing Agents ( 扩容 ) Blood volume increasing Agents ( 扩容 )
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Anticoagulants Thrombolytic agents Coagulants
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Background Hemostasis Process Vessel contraction Vessel contraction Thrombokinesis Thrombokinesis Platelets aggregation Fibrin formation Fibrinolysis Fibrinolysis
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Background Fa II II a Fg Fb PgPlasmin Pg Plasmin Activators + PAI
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Anticoagulants
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Classification Anti-factors: Anti-factors: Heparin, Warfarin Anti-platelet agents: Anti-platelet agents: Aspirin, Persantin,Ticlid Thrombolytic agents Thrombolytic agents SK, UK, t-PA
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Anti-factors Heparin Heparin II a structure structure IX a MOA AT III X a(LMWH) MOA AT III X a(LMWH) XI a XI a Heparin XII a Heparin XII a
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Heparin Uses: prevention of thrombi (DIC,MI) Dose control: PT, <10d ADR: Bleed Protamine hypersensitivity, osteoporosis Notice: HBP, ulcer, pregnancy
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Warfarin P.O only, in vivo, effect: 24hr later MOA antagonist of V.K IIVII IX IXXPCPS II a VIIa IX a X a PCaPSa KH 2 KO Carboxylase r- 羧化酶 Warfarin
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Warfarin Uses Uses Prevention of Thrombi in venous Prevention of Thrombi in venous interaction interaction Dose control PT Dose control PT ADR: bleeding, necrosis ADR: bleeding, necrosis
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Anti-platelet agents Platelets aggregation MOA Platelets aggregation Agents: Agents: — COX TXA2, ADP Aspirin — COX TXA2, ADP Aspirin — PDE Camp Ca Persantin — PDE Camp Ca Persantin — PLT aggregation factors Ticlid — PLT aggregation factors Ticlid — Gp IIb/IIIa Tirofiban — Gp IIb/IIIa Tirofiban CVS Uses: to prevent thrombin formation in CVS
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Thrombolytic agents
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MOA plasminogen MOA plasminogen activate SK, UK, t-PA activate SK, UK, t-PA plasmin plasmin fibrinogen,fibrin fibrinogen, fibrin Uses 2-8 hs after MI
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Coagulants
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Classification Adrenosem,pituitrin vessel contractor (Adrenosem,pituitrin) platelet K 1,2 - nature, fat-soluble Vitamin K (K 1,2 - nature, fat-soluble K 3,4 - synthetic, WS K 3,4 - synthetic, WS ) Reptilase thrombin (Reptilase) PAMBA, AMCHA fibrinogen / fibrin (PAMBA, AMCHA)
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Songhui
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Outline Anti-Anemia agents White cells stimulants White cells stimulants Blood Volume Increasing agents
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Anti-Anemia
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Iron-deficiency anemia Iron-deficiency anemia Megaloblastic anemia Megaloblastic anemia Classification
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Iron-deficiency anemia Backgroud Backgroud Hb Iron: Hb red meat supply: red meat absorption & storage: Fe Vit.C HCl Fe ++ Fe +++ t&s Fe ++ Fe Vit.C HCl Fe ++ Fe +++ t&s Fe ++ diagnosis: PT/TIBC < 10%(35%) Symptoms: fatigue, pica
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Iron-deficiency anemia Agents Agents Oral ferrous sulfate Parenteral iron dextran ADR ADR stimulating reactions Overdose----phosphate deferoxamine
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Megaloblastic anemia Backgroud: folic acid, VB 12 folic acid, VB 12 Supply: Vegetable, Animal Supply: Vegetable, Animal Function: DNA, lipin Function: DNA, lipin
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Megaloblastic anemia L-MCoA ScCoA LIPIN FH2 E Folate E 5-MFH 4 CH3 B12 B12 E FH4 C-FH4 CH3-B12 dUMP dTMP DNA C Homocysteine Methionine A: B12 B: 半胱氨酸 蛋氨酸 甲基丙二酰 CoA 琥珀酰 CoA B12 B12 E 尿嘧啶脱氧核苷酸 胸腺嘧啶脱氧核苷酸
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Megaloblastic anemia Folic acid RNA: DNA Megaloblastic anemia absorbed in intestine: 5-MFH 4 5-MFH 4 liver Therapy B 12 folic acid(calcium leucovorin)+ B 12
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Megaloblastic anemia B 12 B 12 Background mainly from animal absorbed with IF Storage in liver 5-MFH4 B12 FH4 lipin synthesis of nerves
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Megaloblastic anemia Deficiency FH4 Megaloblastic anemia & CNS symptoms Etiology Some gastrointestinal diseases IF therapy B 12 & folic acid use together. B 12 & folic acid use together.
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Depression of the bone marrow Depression of the bone marrow Anemia associated with chronic renal failure (CRF) Anemia associated with chronic renal failure (CRF)
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Anemia from CRF Erythropoietin (EPO) Effect: RBC Uses: CRF, Iron deficiency, Marrow injury, tumors, AIDS. Agent: ESPO
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WBC stimulants---CSF G-CSF: PMN GM-CSF: PMN,MO,Macrophage,PLT USEs Marrow inhibited situations, Chemistry or Radiopraxis Marrow inhibited situations, Chemistry or Radiopraxis AIDS AIDS anemia anemia
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B.V. increasing Agents (Dextran): Features (Dextran): Colloid Osmotic Pressure of plasma excretion is slow no toxicity no antigenicity
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Questions
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Where are the action sites of Anticoagulants and Thrombolytic agents respectively ? Which kind of drug would you choose for an AMI (<8hr.s) patient? A. Antiplatelets B. Coagulants C. Thrombolytics D. Anticoagulants
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Questions Which factors formation dependend on V-K? And which can be inactivated by heparin? A. I A’. Ia B. II B’. IIa C. VII C’. XIa D. IX D’. IXa E. X E’. Xa F. XII F’. XIIa
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Questions 1.What is the active form of folic acid? 2. The functions of B12. 3. Why some patients will get anemia after stomach excision?
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Questions Which would u choose for the patients with Megaloblastic anemia? Iron agents Iron agents Folic acid only Folic acid only G-CFS G-CFS Folic acid & B12 Folic acid & B12
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