1. Cell injury p.1 SYLLABUS:
Robbins and Cotran, Pathologic Basis of Disease, Chapter:
Cellular Responses to Stress and Toxic Insults: Adaptation, Injury, and Death
excluding:
hypertrophy
hyperplasia
metaplasia
necrosis
apoptosis
cellular aging

2. Cell injury p.1
15 Lipofuscin storage in myocardial cells 7929/09 Lipomatous (adipose) atrophy of the pancreas 17 Liver steatosis 22 Hyaline degeneration of the fibrous tissue 20 Calcification 3520/10 Gout (gouty tophus)

3. Lipofuscin storage in myocardial cells
cardiomyocytes containing yellowish-brown intracytoplasmatic granules in a perinuclear location
(candle flame shape)

4. Lipofuscin storage in myocardial cells
(hematoxylin only)

5. Lipofuscin storage in myocardial cells

6. Lipomatous atrophy of the pancreas
replacement of the pancreatic acini by adipose tissue
large areas of total adipose atrophy isolating islands of Langerhans
dilated pancreatic ducts and periductal fibrosis

7. Lipomatous atrophy of the pancreas

8. Lipomatous atrophy of the pancreas

9. Lipomatous atrophy of the pancreas

10. (frozen tissue sample, Sudan III):
Liver steatosis
(paraffin block, H&E):
-clear vacuolar spaces within hepatocytes (accumulated triglycerides were dissolved and removed from cells during the tissue processing)
(frozen tissue sample, Sudan III):
-vacuoles with orange-stained substance (fat)
(.ppt demonstration only, no slides during the microscopy lab)

11. Liver steatosis

12. Liver steatosis

13. Liver steatosis
(paraffin block, H&E):
-clear vacuolar spaces within hepatocytes (accumulated triglycerides were dissolved and removed from cells during the tissue processing)
(frozen tissue sample, Sudan III):
-vacuoles with orange-stained substance (fat)

14. Liver steatosis (Sudan III)

15. Liver steatosis (Sudan III)

16. Hyaline degeneration of the fibrous tissue
thick, eosinophilic collagen fibers
- few fibroblasts

17. Hyaline degeneration of the fibrous tissue

18. Hyaline degeneration of the fibrous tissue

19. Calcification
basophilic calcium deposits within the artery wall

20. Calcification

21. Calcification
(empty areas within the calcium deposits are artifacts)

22. Gout (gouty tophus)
- clusters of pale-staining monosodium urate crystals surrounded by macrophages, lymphocytes and large foreign body giant cells

23. Gout (gouty tophus)

24. Gout (gouty tophus)

25. Gout (gouty tophus)