1. GENERAL ASSEMBLY 4/3/2011 at 12.00-13.45 Aula Magna, Louvain-la-Neuve Belgian Society of Human Genetics

2. 1. Introduction / Overview of past activities of the Board and of the Society (President, Hélène Antoine-Poirel) 2. Financial accounts for approval (Treasurer, Guy Van Camp) 3. Activities of the different workgroups –a. WG on Pre- and Postnatal Cytogenetics “BelCoCyt” (B. Mentens) –b. WG on Cytogenetics for Hematology and Oncology “BCGHO”(L. Michaux / K. Rack) –c. WG on Molecular Genetics “Belmogen” (W. Lissens) –d. WG on Master Course in Human Genetics (M. Abramowicz / W.Wuyts) –e. WG on Training and Accreditation (C. Verellen-Dumoulin) 4. Conclusions of the evaluation of the different WG’s by the Board (Secretary, Thomy. de Ravel) –Closure of WG on predictive testing –Creation of 2 new WG’s: ‘Clinical Genetics’ and Recognition in Medical Genetics Laboratory Specialist 5. Future meetings & general assemblies 6. Varia Agenda 04/03/2011

3. The Board met 10 times: Mar 24 th, May 7 th, Jun 4 th, Aug 3 rd, Sep 7 th, Oct 8 th, Nov 19 th, Dec 10 th, Jan 21 st, Feb 11 th Tasks of the previous treasurer divided into 4 portfolio’s : –G Van Camp – treasurer: Bookkeeping system / Tax / bank document –P Coucke: Fees (membership, post-graduate course, annual meeting) –P Hilbert: Sponsoring –S Van Dooren: Deposition of official documents (annual financial report, change in the composition of the Board…) Organisation of the 11 th Annual Meeting in Louvain-la-Neuve Re-evaluation of membership fees and registration fees –On-line Registration 30 € –Late registration / on-site (in cash)40 € Evaluation of the different Workgroups –Need for accreditation  training, recognition, quality controls, guidelines… Collaboration with the High Council of Human Genetics / College of Medical Geneticists –Genetic councelling : standard vs complex –Genetic tests carried out abroad 1 – Activity report of the board

4. Recognitions in Medical Genetics MD Medical Genetics Laboratory Specialist National Guidelines on the website DNA day (25 th April) HVP : Human Variome Project Work in conjunction with National Human Genetics Societies to establish systems that will automatically collect every mutation reported by a diagnostic laboratory, clinic or research laboratory in an individual country  BeSHG : Interim Membership Next year projects

5. 2. Financial accounts for approval Treasurer Guy Van Camp

6. Income Membership7680.00 Interests57.18 Sponsoring meeting 201024050.00 End balance course6284.62 Total38071,80 2 – BeSHG: Financial Report 2010

7. Expenditure Congress 2010 costs-26276.77 Participation “Capita Selecta Complex Diseases” congress-500.00 Banking costs-15.60 Staatsblad/Moniteur-222.64 Costs website-793.19 Costs meeting board and working groups-191.95 Total28000,15 2 – BeSHG: Financial Report 2010

8. Overview 2010 Income38071,80 Expenditure-28000,15 Balance (profit)10071,65 BeSHG total assets 31/12/201071672,94 2 – BeSHG: Financial Report 2010

9. 3 - Activities of the different WG’s

10. 3a - WG on Pre- and Postnatal Cytogenetics BelCoCyte B. Mentens

11. BelCoCyt BeSHG Workgroup on Constitutional Post- and Prenatal (Molecular) Cytogenetics

12. Guidelines for prenatal and postnatal cytogenetics Accreditation of (molecular) cytogenetics Guidelines for array CGH New art. 33 - RIZIV/INAMI Exchange of “difficult” cases Discussion of special cases, observations, meetings etc. BelCoCyt

13. UZBrusselAnne-Mie Bael AnneMie.Bael@uzbrussel.beAnneMie.Bael@uzbrussel.be Ann Van Den Bogaert Ann.Vandenbogaert@uzbrussel.beAnn.Vandenbogaert@uzbrussel.be Catherine Staessens Catherine.Staessen@uzbrussel.beCatherine.Staessen@uzbrussel.be Tine Venkentine.venken@uzbrussel.betine.venken@uzbrussel.be UZA Jan Wauters jan.wauters@ua.ac.bejan.wauters@ua.ac.be Elvire Van Assche Elvire.Van.Assche@uza.beElvire.Van.Assche@uza.be Frank Kooyfrank.kooy@ua.ac.befrank.kooy@ua.ac.be KUL Joris Vermeesch joris.vermeesch@uzleuven. bejoris.vermeesch@uzleuven. be Cindy Melotte Cindy.Melotte@uzleuven. beCindy.Melotte@uzleuven. be Kris Van Den Bogaertkris.vandenbogaert@uzleuven.bekris.vandenbogaert@uzleuven.be ULg - CHU LiègeMauricette Jamar Mauricette.Jamar@chu.ulg.ac.beMauricette.Jamar@chu.ulg.ac.be Anne-Cécile Hellin ac.hellin@chu.ulg.ac.beac.hellin@chu.ulg.ac.be Lionel Habran lionel.habran@chu.ulg.ac.belionel.habran@chu.ulg.ac.be ULBChristine Hans chans@ulb.ac.bechans@ulb.ac.be Bruno Pichon bpichon@ulb.ac.bebpichon@ulb.ac.be Anne De Leener andeleen@ulb.ac.beandeleen@ulb.ac.be Montse Urbina Montse.Urbina@ulb.ac.beMontse.Urbina@ulb.ac.be UZGentBjörn Menten bjorn.menten@ugent.bebjorn.menten@ugent.be IPGSonia Rombout sonia.rombouts@ipg.besonia.rombouts@ipg.be Benoît Parmentier benoit.parmentier@ipg.bebenoit.parmentier@ipg.be Bernard Grisart bernard.grisart@ipg.bebernard.grisart@ipg.be UCLCatherine Sibille catherine.sibille@gmed.ucl.ac.becatherine.sibille@gmed.ucl.ac.be Marie Ravoet marie.ravoet@gmed.ucl.ac.bemarie.ravoet@gmed.ucl.ac.be Winnie Courtens winnie.courtens@uclouvain.bewinnie.courtens@uclouvain.be BelCoCyt: Members

14. BCGHO 3b – WG on Cytogenetics for Hematology & Oncology L. Michaux / K. Rack

15. Belgian Society of Human Genetics Workgroup on Cytogenetics for Hemato-oncology BCGHo

16. Workgroup created in 2004 Secretary: K.Rack-IPG; Chairperson: L.Michaux-KULeuven (past A.Hagemeijer, F.Speleman) Attendence representatives from the Belgian Centres for Human Genetics (and from the Department of Clinical Biology in Bruges), fellows BCGHo

17. Geneviève AmeyeUCL Marleen BakkusVUB Barbara CauwelierAZ Sint Jan Brugge Maria Debiec-RychterKUL Barbara.DessarsULB Francois DuhouxUCL Anne HagemeijerKUL Pierre HeimannULB Christian HerensULG Mauricette JamarULG Jeanne-Marie LiboutonUCL Judith LucianiUCL Lucienne Michaux KUL Natalie PutKUL Hélène Antoine-PoirelUCL Bruce PoppeRUG Katrina Rack IPG Daniel SartenaerIPG Frank Speleman RUG Elvire Van AsscheUZA Nadine Van Roy RUG Peter VandenbergheKUL Iwona WlodarskaKUL BCGHo: Participants 2011

18. Meetings 2-3x/ year Activities: Guidelines for the cytogenetic and molecular genetic analysis of acquired disorders Education: 1. Presentations (by members of the group or by invited speakers) a. methodological problems or b. case discussions or c. studies 2. Summary and reports on scientific meetings 3. Project: continuous education of technicians, participation to the discussions on the recognition as Medical Genetics Laboratory Scientist Technical developments (with 1 multi-centric survey conducted and published on culture techniques in chronic lymphocytic leukemia) Accreditation, External quality control : shared experience, practical aspects Scientific: review of cytogenetic files of patients included in trials (i.e. conducted by the GFCH) BCGHo

19. 3c - WG on Molecular Genetics BELMOGEN W. Lissens

20. LAB people in Moleculer Genetics from the 8 Belgian Centres for Human Genetics: BELMOLGEN Workgroup of the BeSHG since April 2008 BELMOLGEN: Report

21. Three meetings in 2009: 30 January, 25 September, 4 December Four meetings in 2010: 5 March, 4 June, 8 October, 10 December BELMOLGEN

22. Methodology (technology): -DNA isolation -HRM -capillary electrophoresis -sequencing, next generation sequencing -review of raw data from sequencing, HRM,..(manual, software, …?) -…… BELMOLGEN: major subjects (1 of 3)

23. Diseases, case reports: -Rett syndrome -hyperekplexia -BRCA -hemochromatosis -pharmacogenetics -…. BELMOLGEN: major subjects (2 of 3)

24. Logistics, strategy, quality: -article 33 -Update BELBIS -Sending samples abroad (analysis not done in Belgium) -accreditation -guidelines / quality control (SCA, FRAXA, EMQN) -…. BELMOLGEN: major subjects (3 of 3)

25. Change of format (since December 2009): -3-4 meetings/year -presentations by 2 centers/meeting + free communications -meeting UZ Brussel BELMOLGEN

26. -Recognition of ‘scientists’ in genetics -Collaboration with other Workgroups -Improve reporting + communication (reports, recommendations,..): website BeSHG? BELMOLGEN: future

27. 3d - WG on Master Course in Human Genetics M. Abramowicz & W. Wuyts

28. - first organized 2008-2009 - Inter-University course on Human Genetics - 8 days of course + additional work + exam - each day organized by one of 8 Belgian Genetic Centres - Thompson and Thompson Genetics in Medicine - 53 students registered, 39 students took exam BeSHG workgroup on Master course in Genetics

29. - 2009-2010 - on Fridays instead of Saturdays - 12 students showed up for exam -2010-2011 was skipped -2011-2012 dates: 14/10/2011 (?) KUL 18/11/2011 ULB 09/12/2011 UGent 20/01/2012 IPG 17/02/2012 UCL 16/03/2012 UA 20/04/2012 ULG 18/05/2012 VUB BeSHG workgroup on Master course in Genetics

30. 3e - WG on Training and Accreditation C. Verellen-Dumoulin

31. WG on Predictive Genetic Testing: In accordance with the recommendations of this WG, this WG has been disbanded. WG on Training and Accreditation: This WG is still busy. The Chairperson had been encouraged to bring this task to a head. WG on Molecular Genetics: WG on Making a Master on Master course in Genetics: WG on Cytogenetics of Acquired Diseases (BCGHO): WG on Constitutional Post- and Prenatal (Molecular) Cytogenetics: 4a – The evaluation of the WG’s

32. –Workgroup « Clinical Genetics »: 27 th October 2010 Brain-storming Meeting 28 th January 2011 Standard vs complex genetic counselling (INAMI-RIZIV / HCHG) –« Recognition in Medical Genetics Laboratory Specialist » Temporary WG : finalisation of the rules for qualification Permanent WG : evaluation of the applications & renewals –Workgroup Dysmorphology 4b – Creation of 2 new WG’s

33. Next general assembly ! 5 – BeSHG future meetings

34. 2013 Brussels 5 – BeSHG future meetings

35. ???? 6 - Varia

36. Belgian Society of Human Genetics www.beshg.be Enjoy the lunch & posters: Satellite presentation : 13:30-13:40 Caliper 13:40-13:50 Agilent Thank you ! 7 - Closing