2 The Slides Slide 1: Intraductal Carcinoma of the Breast Slide 2: Invasive Duct Carcinoma of the BreastSlide 3: Paget’s Disease of the BreastSlide 4: Dermoid Cyst of the Ovary
3 Intraductal Carcinoma of the Breast Slide shows the following: Large ducts are distended by neoplastic epithelial cells which are pleomorphic with hyperchromatic nuclei; some exhibiting MitosesCells form imperfect acini and show Cribriform patternSmall groups of necrotic cells in the center of many ductsNo invasion of Basement Membrane of the ducts
9 Invasive Duct Carcinoma of the Breast Slide shows the following: Cords, Sheets & nests of tumor cells surrounded by dense fibrous tissue, stroma containing scattered lymphocytesTumor cells are Round or Polygonal with deeply stained nuclei & occasional mitosesFocal tumor cells necrosisInvasion of Breast Adipose tissue by Tumor cellsFew tumor cells form Duct-Like structures
16 Paget’s Disease of the Breast Slide shows the following: Ulceration and invasion of epidermis by ductal carcinoma cells (Paget cells), present between basal cells in elongated rete pegsPaget cells are Large, anaplastic cells having pale cytoplasm, hyperchromatic nuclei with occasional mitosisPaget cells are present in either singly or in small groups of 2 or 3 surrounded by a clear zone “Halo”Deeper tissue shows Intraductal proliferation of neoplastic epithelial cells
19 Ulceration & Invasion of epidermis by Paget Cells Rete PegsPaget Cells
20 Paget Cells Showing all previously mentioned Features: -Large, anaplastic, pale cytoplasm, hyper chromatic Nuclei, clear Halo zone
21 Dermoid Cyst of Ovary Slide shows the following: Stratified squamous epithelium with underlying appendages (sweat glands, sebaceous glands, hair follicles), columnar ciliated epithelium, mucous & serous glands and structures from other germ layers such as Bone, Cartilage, Lymphoid tissue, Smooth muscle and large area of Brain Tissue containing Neurons and Glial cells.