1. Le CRNH-IdF Centre de Recherches en Nutrition Humaine d’Ile de France Alain GRYNBERG

2. Clinical investigation Basic science CV risk diabetes (Jean Verdier) Food economy (INRA) Obesity center genotyping (La Pitié) Gut, satiety digestion CRV ( Avicennes ) Epidemiology (INRA-INSERM-Paris13) Protein, satiety digestion (INRA, AgroParisTech) Adipose tissue (INSERM, Paris 6) 150<employees<200 Publications>100/y

3. URA 1303 ALISS LG Soler INRA Ivry Gastroenterology -Hepatology R Benamouzig AVC-UP13 CRV R Benamouzig AVC-UP13 Nutrition JM Oppert LPS-UP6 Genotyping K Clément Ambulatory Exploration JM Oppert LPS-UP6 Endocrinology- diabetology- Nutrition P Valensi JV-UP13 UMR Inserm U872 K Clément UP6 U914 D Tome Agroparistech Endocrinology- Diabetology G Reach AVC-UP13 COPIL Scientific council Direction UMR U557 /U1125 S Hercberg SMBH-UP13 Gut, satiety Obesity / AdT compliance Risk factors Clinical investigations Epidemiology Economy

4. Scientific Activity 1 Dietary behaviour & food consumption General population Specific populations Variability Typologies dietary behaviour and consumption children, elderly, socio-demographic and socio- economic categories, diseased populations evolution of behaviour, regional variations food consumption data collection & new tools design, methodology for global nutrition and creation of dietary typologies

5. Scientific Activity 2 Determinant factors of behaviour on food consumption & nutritional status economical social sensorial psycho-physiological physio-pathological costs vs nutritional quality, socio-economic level, food supply vs demand taste training, food acceptability, lifestyle, life cycles, … hunger & satiety, satiety in the course of meal, attitudes and beliefs, energy density in food, portion size, conviviality & stimuli initiation and stop of eating, mechanisms of nycthemeral periodicity; conditioning and training physical activity, physiological and pathological situations

6. Scientific Activity 3 Dietary behaviour & health Quality of life Physiological functions Risk factors Morbi-mortality Interactions genetic factors / risk factors / behaviour hormonal, cardiovascular, adipose, digestive overweight, HTA, dyslipidemia, metabolic syndrome

7. Prevention strategies Market & behaviour Social marketing of information Transfer to population Effects of information on behaviour & corpulence Effects of information and product characteristics on food choices Education strategies for health considering population specificities. Compliance to nutritional recommendations Scientific Activity 4

8. Main clinical explorations available in Paris-13 sites Indirect calorimetry stable isotope tracers biphotonic absorptiometry Avicenne Pr R Benamouzig, Dr G Airinei Gastro-entero-hepatology  300 m2 heavy clinical exploration  Body composition  Ambulatory and resting energy expenditure  Qualitative and quantitative analysis of dietary behaviour  Metabolic & hormonal profile  Behaviour study boxes  Intestinal perfusion coupled to stable isotope tracers  Gut motility and gastric emptying (stable isotopes-echography)  Digestive tract biopsies, faecal and colonic flora

9. Main clinical explorations available in Paris-13 sites Jean Verdier Hospital Pr Paul Valensi, Pr Emmanuel Cosson Endocrinology, CV risk factors  Body composition  Ambulatory and resting energy expenditure  Qualitative and quantitative analysis of dietary behaviour  Metabolic & hormonal profile  Insulin-resistance coupled to calorimetry  Insulin secretion and sensibility to insulin  Peripheral endothelial function, artery compliance and CV autonomic activity  CV activity & echocardiography  Non invasive AGE measurement  Continuous glycaemic profile (G-Holter) Microcirculation by laser doppler Arterial compliance endothelial function Body composition

10. Main clinical explorations available in Paris 6 site La Pitié Salpétrière Pr JM Oppert, Pr K. Clément Obesity, adipose tissue  Unit of ambulatory exploration in obesity  Ambulatory and resting energy expenditure  Body composition  Qualitative and quantitative analysis of dietary behaviour  Metabolic & hormonal profile  Exercice training for obese patients  Adipose tissue phenotyping  Functional genomic  Genetic epidemiology, mutations & polymorphisms

11. The Projet : Phenotyping Harmonization Body composition Hormonal & metabolic profile endothelial function glycaemic profile Free living investigations technical protocols & equipment harmonization CRNH IdF AVC LPS JV AVC LPS JV IdF Auvergne Ouest Rhone Alpes

12. The Projet : Scientific Development Diabetes, CVD Subclinical cardio-vascular changes in the alterations of vago- sympathetic balance in prediabetes Postprandial changes in the vago-sympathetic balance across the glycemic continuum from normoglycemia to prediabetes and diabetes Geographic origin, psycho-social deprivation and diet as predictive factors for gestational diabetes mellitus Digestion, Satiety Microbiota Quality of the source of proteins Obesity Microbiota