1. SPINTRONIC NANOSENSORS for MEDICINE Prof. Riccardo Bertacco Centro LNESS Politecnico di Milano Via Anzani 42, 22100 Como riccardo.bertacco@polimi.it

2. Riccardo Bertacco 2 Spintronic biosensors for molecular recognition R R’  No background  No bleaching  High stability  Molecule handling  High biological sensitivity  Tayloring the dinamic range  Lab on chip Advantages Disadvantages  Not label free  Impact of beads on the chemical affinity ? biotin streptavidin target probe

3. Riccardo Bertacco SpinNanoMed FP7: NMP-2008-1.1-1 Converging sciences and technologies (nano, bio, info and/or cognitive) 3 End users Antibody MicroarraysC. Borrabaeck, Create (Sweden) User Interface, Data correlation and knowledge discovery Database and Web Group – Bioinformatics Lab P. Fraternali, S. Ceri, M. Masseroli Politecnico di Milano (Italy) Signal de-noising and data analysis Digital Signal Processing Group- ISP Lab M. Tagliasacchi Politecnico di Milano (Italy) Signal read-out and LabOnChip electronics Microfluidic transport Institut fur Mikrotechnok Mainz GmbH K. S. Drese (Germany) Surface functionalizationICRM M. Chiari CNR (Italy) Microfabrication of lab on chip micro arrays of spintronic biosensors Spintronic group at LNESS nanoGune MIC - Copenhagen R. Bertacco Politecnico di Milano (Italy) A. Berger, P. Vavassori (Spain) M. F. Hansen (Denmark) SPINTRONIC NANOSORS for MEDICINE  Preventive medicine and diagnosis (in vitro diagnostic tests)  Specific application: Early detection of breast cancer via proteome profiling on the serum of patients Lab on chip approach for point of care applications.

4. Riccardo Bertacco Read out electronics (ASIC) System layout substrate Insulating layer SiO2 + polymer Microfluidics AD conversion DSP Data mining End user interface Biomedical validation

5. Riccardo Bertacco Electronics An ASIC, to be placed around the sensor chip, must be designed and realized with these functionalities: front end electronics for the signal read out analogical signal processing (filtering, amplification,...) A second external circuit will make the analog to digital conversion and provide suitable signal to an external PC for data acquisition and analysis.