1. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
The Heart
Illustrations are taken from:
J. Malmivuo, R. Plonsey, Bioelectromagnetism, Oxford Press, 1995
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

2. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
Location of the Heart
The heart is located in the chest between the lungs behind the
sternum and above the diaphragm.
It is surrounded by the pericardium.
Its size is about that of a fist, and its weight is about g.
Its center is located about 1.5 cm to the left of the midsagittal plane.
Located above the heart are the great vessels: the superior and inferior vena cava, the pulmonary artery and vein, as well as the aorta.
The aortic arch lies behind the heart.
The esophagus and the spine lie further behind the heart.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

3. Location of the heart in the thorax
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

4. The anatomy of the heart and associated vessels
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

5. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
Anatomy of the Heart
The heart is oriented so that the anterior aspect is the right
ventricle while the posterior aspect shows the left atrium.
The atria form one unit and the ventricles another.
The left ventricular free wall and the septum are much thicker
than the right ventricular wall. This is logical since the left
ventricle pumps blood to the systemic circulation, where the
pressure is considerably higher than for the pulmonary
circulation, which arises from right ventricular outflow.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

6. Orientation of cardiac muscle fibers
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

7. Anatomy of striated muscle
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

8. Blood circulation via Heart
The blood returns from the systemic circulation to
the right atrium and from there goes through the
tricuspid valve to the right ventricle.
It is ejected from the right ventricle through the
pulmonary valve to the lungs. Oxygenated blood returns
from the lungs to the left atrium, and from there
through the mitral valve to the left ventricle.
Finally blood is pumped through the aortic valve to
the aorta and the systemic circulation..
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

9. Electrophysiology of Cardiac Muscle Cell
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

10. Electrical activation of the Heart
In the heart muscle cell, or myocyte , electric activation takes place
by means of the same mechanism as in the nerve cell -
that is, from the inflow of sodium ions across the cell membrane.
The amplitude of the action potential is also similar, being about
100 mV for both nerve and muscle. The duration of the cardiac
muscle impulse is, however, two orders of magnitude longer than
that in either nerve cell or skeletal muscle. A plateau phase follows
cardiac depolarization, and thereafter repolarization takes place.
As in the nerve cell, repolarization is a consequence of the outflow
of potassium ions.
The duration of the action impulse is about 300 ms (Netter, 1971).
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

11. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

12. Mechanical contraction of Cardiac Muscle
Associated with the electric activation of cardiac muscle cell
is its mechanical contraction, which occurs a little later.
An important distinction between cardiac muscle tissue and
skeletal muscle is that in cardiac muscle, activation can propagate
from one cell to another in any direction.
As a result, the activation wavefronts are of rather complex shape.
The only exception is the boundary between the atria and ventricles,
which the activation wave normally cannot cross except along a
special conduction system, since a nonconducting barrier of fibrous
tissue is present..
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

13. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
Electric and mechanical activity in (A) frog sartorius muscle cell, (B) frog cardiac muscle cell, (C) rat uterus wall smooth muscle cell. In each section the upper curve shows the transmembrane voltage behavior, whereas the lower one describes the mechanical contraction associated with it.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

14. The conduction system of the heart.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

15. Conduction on the Heart
The sinoatrial node in humans is in the shape of a crescent and
is about 15 mm long and 5 mm wide.
The SA nodal cells are self-excitatory, pacemaker cells.
They generate an action potential at the rate of about 70 per minute.
From the sinus node, activation propagates throughout the atria,
but cannot propagate directly across the boundary between atria
and ventricles.
The atrioventricular node (AV node) is located at the boundary
between the atria and ventricles; it has an intrinsic frequency of
about 50 pulses/min. However, if the AV node is triggered with
a higher pulse frequency, it follows this higher frequency.
In a normal heart, the AV node provides the only conducting
path from the atria to the ventricles. Thus, under normal conditions,
the latter can be excited only by pulses that propagate through it.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

16. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
Propagation from the AV node to the ventricles is provided by a
specialized conduction system.
Proximally, this system is composed of a common bundle, called the
bundle of His (after German physician Wilhelm His, Jr., ).
More distally, it separates into two bundle branches propagating along
each side of the septum, constituting the right and left bundle
branches. (The left bundle subsequently divides into an anterior and
posterior branch.) Even more distally the bundles ramify into Purkinje
fibers (named after Jan Evangelista Purkinje (Czech; ))
that diverge to the inner sides of the ventricular walls. Propagation
along the conduction system takes place at a relatively high speed
once it is within the ventricular region, but prior to this (through the
AV node) the velocity is extremely slow.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

17. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
Propagation on ventricular wall
From the inner side of the ventricular wall, the many activation sites
cause the formation of a wavefront which propagates through the
ventricular mass toward the outer wall.
This process results from cell-to-cell activation. After each ventricular
muscle region has depolarized, repolarization occurs.
Repolarization is not a propagating phenomenon, and because the
duration of the action impulse is much shorter at the epicardium (the
outer side of the cardiac muscle) than at the endocardium (the inner
side of the cardiac muscle), the termination of activity appears as if
it were propagating from epicardium toward the endocardium.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

18. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
Electrophysiology of the heart The different waveforms for each of the specialized cells
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

19. Isochronic surfaces of the ventricular activation
(From Durrer et al., 1970.)
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

20. The genesis of the electro-cardiogram
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

21. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
A and B show a segment of cardiac tissue through which propagating
depolarization (A) and repolarization (B) wavefront planes are passing.
In this illustration the wavefronts move from right to left, which
means that the time axis points to the right.
There are two important properties of cardiac tissue that we shall
make use of to analyze the potential and current distribution
associated with these propagating waves.
First, cells are interconnected by low-resistance pathways
(gap junctions), as a result of which currents flowing in the
intracellular space of one cell pass freely into the following cell.
Second, the space between cells is very restrictive (accounting for
less than 25% of the total volume). As a result, both intracellular
and extracellular currents are confined to the direction parallel to
the propagation of the plane wavefront.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

22. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
Electric field of the heart on the surface of the thorax, recorded by Augustus Waller (1887).
The curves (a) and (b) represent
the recorded positive and negative isopotential lines, respectively.
These indicate that the heart is a dipolar source having the positive and negative poles at (A) and (B), respectively.
The curves (c) represent the
assumed current flow lines..
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

23. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
(A) The 10 ECG leads of Waller. (B) Einthoven limb leads and Einthoven triangle. The Einthoven triangle is an approximate description of the lead vectors associated with the limb leads.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

24. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
Einthoven Triangle
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

25. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
The signal produced by the propagating activation front between a pair of extracellular electrodes.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

26. The generation of the ECG signal in the Einthoven limb leads - I
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

27. The generation of the ECG signal in the Einthoven limb leads - II
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

28. The normal electrocardiogram
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

29. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
The Wilson central terminal (CT) is formed by connecting a 5 k resistance to each limb electrode and interconnecting the free wires; the CT is the common point. The Wilson central terminal represents the average of the limb potentials. Because no current flows through a high-impedance voltmeter, Kirchhoff's law requires that IR + IL + IF = 0.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

30. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
(A) The circuit of the Wilson central terminal (CT). (B) The location of the Wilson central terminal in the image space (CT'). It is located in the center of the Einthoven triangle.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

31. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
(A) The circuit of the Goldberger augmented leads. (B) The location of the Goldberger augmented lead vectors in the image space.
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

32. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
Precordial leads
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu

33. EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu
The projections of the lead vectors of the 12-lead ECG system in three orthogonal planes (when one assumes the volume conductor to be spherical homogeneous and the cardiac source centrally located).
EE-515 Bioelectricity & Biomagnetism 2002 Fall - Murat Eyüboğlu