1. Structure, Replication, Transcription, Translation

2.  You will be responsible for knowing the people and their contribution to history.  Be able to describe the experiment they ran and its conclusion.  You are not responsible for spelling names correctly, what the scientist looked like, or any dates.  Take notes. Do not copy slides.

3. 1869 Johann Friedrich Miescher identified and isolated DNA in his laboratory, but did not know its function.

4.  Tubingen University, Germany.

5. 1928 Fredrick Griffith discovers genetic information can be transferred from dead bacteria to live bacteria.

7. 1944 Oswald Avery suggests DNA as genetic information in Griffith’s experiment. J Exp Med-1944-Avery-137- 58.pdf

8. 1952 Hershey and Chase proved that Avery was correct

9. Made phosphorus (found in DNA, but not in protein) radioactive in viruses. Bacteria became radioactive after exposure due to DNA.

10. 1949 Erwin Chargaff discovered that DNA composition (amount of A, T, C, and G) is species specific. He also discovered that amount of G = C and A = T.

11. 1953 Watson and Crick discover the molecular structure of DNA

14. The major and minor groove are important for replication. Note the dimensions: 2.0 A° = 2 nm (1 nm = 0.000000001 m). The major groove is 3.4 A°, which is about 10.5 base pairs and = 1 complete turn. Sketch this.