2. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC U.S. ARMY MEDICAL RESEARCH & MATERIEL COMMAND MG George Weightman - Commanding Colonel Karl Friedl, Director, Telemedicine & Advanced Technology Research Center (TATRC) Heather White, DoD Research Specialist, Office of Sponsored Programs Telemedicine and Advanced Technology Research Center … Fulfilling The Vision Thru R&D USAMRMC & TATRC Overview

3. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Agenda 1.Command Structure/Organization 2.TATRC Background and Mission 3.Funding Mechanisms 4.Research Areas of Interest 5.Other Collaborative Opportunities 6.Closing

4. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Medical Research and Materiel Command Overview Mission and Vision We are the world’s experts and leaders in the military relevant biomedical research and medical materiel communities, delivering the best medical solutions to enhance, protect, treat, and heal our warfighters. Provide medical knowledge and materiel lifecycle management to protect, treat and optimize warfighter health and performance across the full spectrum of operations. MISSION VISION

5. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC U.S. ARMY MEDICAL DEPARTMENT ORGANIZATION CHART MEDICAL COMMAND (MEDCOM) OFFICE OF THE SURGEON GENERAL MEDICAL RESEARCH & MATERIEL COMMAND (USAMRMC) AMEDD CENTER & SCHOOL REGIONAL MEDICAL COMMANDS DENTAL COMMAND (DENCOM) VETERINARY COMMAND (VETCOM) CHPPM* *Center for Health Promotion and Preventive Medicine MG Weightman CG, USAMRMC

6. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Command Relationships & Personnel USAMRMC HEADQUARTERS Medical Research & Technology Medical Advanced Development Medical Logistics Medical IM/IT Health Facilities Procure- ment Support WRAIRUSAMMDAUSAMRAAUSAMMAUSAMITCUSAHFPAUSAMMCEUSAARLUSAISRUSAMRICDUSAMRIIDUSARIEM MILITARYCIVILIANCONTRACTORTOTAL 1,0042,3842,9296,317 15.89%37.74%46.37%100.00% USAMRMC Actual Personnel – Sep 2008 TATRC CDMRP

7. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Core Medical S&T Program Areas Military Infectious Diseases Medical readiness Vaccines Biotechnology Prophylaxis/treatment drugs Diagnostics/prognostics Vector control Military Operational Medicine Soldier selection and sustainment Soldier performance Warrior system modeling Health hazards protection Diagnostics/prognostics Health monitoring Clinical Rehabilitative Medicine Prosthetics Regenerative Medicine Clinical Studies Ocular and Auditory Rehabilitation & Repair Intramurally funded Management costs from President’s Budget 88% of S&T budget goes to in-house DOD labs ; The S&T objectives are placed into the POM cycle budget request (5-7 years out) Combat Casualty Care Lightweight medical equipment Medical C4ISR Trauma care Health monitoring and diagnostic technology

8. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Explore science and engineering technologies ahead of programmed research, leveraging other programs to maximize benefits to military medicine Be the government model of opportunity-driven research agility Mission Vision Telemedicine and Advance Technology Research Center

9. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Evolution of TATRC DIN/PACS and Teleradiology Filmless Hospital Telemedicine and e-health Establishment of Gap Funding  Innovation in Managing Technology Ability to Harness - Academic innovation - Congressional interests - Industrial investment  Aligning CSIs to the Larger Army Medical Research Objectives  Facilitate Innovations for the Command  Spearhead Collaboration Across Agencies

10. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Congressional Special Appropriations – RDT&E TATRC…….. Element of HQ, USAMRMC Shapes Congressional Special Interest projects to DoD relevance Leads DoD research in e-Health (computational biology & clinical informatics) Bridges military medical research gaps & promotes innovative pilot research Manages large cutting edge R&D programs 15 Core Research Portfolios > 800 active projects SBIR/Gap funds management 16-20% - Withhold DHP, Economic improvement, SBIR/STTR, MRMC, TATRC TATRC FUNDING HISTORY - Since FY98, $2.10B managed R&D projects

11. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Neuroscience Dr. Ken Curley Regenerative Medicine Dr. Eva Lai Nano-Medicine and Biomaterials Dr. Warren Grundfest Medical Logistics Mr. John DePasquale Integrative Medicine Dr. Jean Louis Belard Genomics/ Proteomics Dr. Anne Westbrook Research Portfolios Key Product Lines Medical Robotics Dr. Gary Gilbert Health Information Technologies CDR Stephen Steffenson Medical Imaging Technologies Dr. Anthony Pacifico Advanced Prosthetics and Human Performance Mr. Troy Turner Computational Biology Dr. Jacques Reifman Biomonitoring Technologies Dr. Eva Lai Simulation and Training Technology Mr. Gene Wiehagen New Initiatives & Basic Science BHSAI BIC Current Staff 6 Military Officers 8 Civilians 54 IPAs (includes 10 part time) 88 Contractors 5 Consultants Coordinating Partnerships RAD I: Infectious Disease RAD II: Combat Casualty Care RAD III: Operational Medicine RAD IV: Clinical Rehab Medicine Infectious Disease Ms. Amber Stanley Trauma Dr. Tim Broderick Human Performance Optimization Dr. Sylvain Cardin Neuro- Rehabilitation MAJ Teresa Brininger Acoustic Trauma Dr. Michael Holtel

12. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Research & Development Strategies Link to the Warfighter New Ideas, Knowledge High Risk, High Payoff Innovation, Transition Academia + Government + Industry (Maximum Bang for Buck) Service Labs Academia DARPA Industry Expanded Resource Base International Coalitions Stryker Brigade – Deployed Forces Interagency Partners

13. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC www.tatrc.org

14. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC USAMRMC BAA 08-1 USAMRMC BAA 08-1 The USAMRMC Broad Agency Announcement (BAA) 08-1 is intended to solicit research ideas that work towards providing solutions to medical problems of importance to the American warfighter at home and abroad. SBIR/STTR SBIR/STTR Small Business Innovative Research (SBIR) and Small Business Technology Transfer (STTR) are highly competitive programs designed to allow small businesses to harness their innovative talents, with the incentive to profit from commercialization. AMEDD Advanced Medical Technology Initiative (AAMTI) AMEDD Advanced Medical Technology Initiative (AAMTI) The U.S. Army Medical Research and Materiel Command's (USAMRMC) mission is to provide solutions to medical problems of importance to the American war fighter at home and abroad. The AMEDD Advanced Medical Technology Initiative (AAMTI) plays a vital role in the fulfillment of these objectives.

15. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC USAMRMC Broad Agency Announcement (BAA) 08-1 *Provides a general description of USAMRMC’s research programs Specific areas of interest General information Evaluation and selection criteria Proposal preparation instructions *BAA is continuously open, 24/7 *Accepts proposals on a rolling basis. *Pre-proposals may be submitted and will be evaluated at any time throughout the year.

16. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Research Areas of Interest Military Infectious Diseases Research Program Combat Casualty Care Research Program Military Operational Medicine Research Program Medical Biological Defense Research Program Medical Chemical Defense Research Program Telemedicine and Advanced Technology Program Special Programs

17. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Military Infectious Diseases Research Program –Vaccines (characterization, development, pathology) –Antiparasitic Drugs (discovery, design, & development) –Vector Development (arthropod vectors & vector- borne diseases) –Therapeutic drug development (screen, synthesize, and develop)

18. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Combat Casualty Care Research Program –Stop blood loss Limit the immediate, short- and long-term deleterious consequences of severe hemorrhage Non/Minimally invasive sensors to detect and warn of impending vascular collapse Improved preservation, storage, transportability, and processing of red blood cells, platelets, and plasma –Traumatic Brain Injury Non/Minimally invasive sensors or assays to rapidly diagnose the severity of brain injury Drugs, biologics, or other agents to mitigate post-injury affects –Secondary Damage to Organs –Additional Aspects of Casualty Care

19. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Military Operational Medicine Research Program –Injury Prevention and Reduction –Psychological Health and Resilience –Environmental Health and Protection –Physiological Health Medical Biological Defense Research Program –Viral, Toxin and Bacterial Studies –Drug Development Development, synthesis and testing of compounds that possess antiviral, antibacterial, immunomodulatory or antitoxin activities –Identification and Diagnosis of antigens and antibodies

20. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Medical Chemical Defense Research Program –Maintain the Technologic Capability to meet present requirements and counter future chemical warfare agent threats. –Provide Medical Countermeasures for the individual soldier to maintain combat effectiveness and prevent or reduce injury from chemical warfare agents. –Provide Medical Management of Chemical Casualties to enhance survival and expedite the return-to-duty of chemical warfare agent casualties through definitive therapies and life support technologies.

21. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Telemedicine & Advanced Technology Program –Medical Robotics – to treat patients in fixed and mobile medical facilities –Health Information Technologies –Medical Imaging Technologies – portable, high performance, decision support, advanced surgical cameras –Advanced Prosthetics & Human Performance –Computational Biology - analysis, interpretation, prediction, and modeling of biological data –Biomonitoring Technologies - remote and wireless –Simulation and Training Technology –Genomics and Proteomics - signatures and markers –Chronic Disease Management

22. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Telemedicine Cont. –Infectious Disease - vaccines, therapeutic agents, diagnosis, vector control, wound infections, and sepsis –Neuroscience - training, treatment, prevention, protection, assessment, and diagnosis. –Regenerative Medicine – development of treatments for damaged/non-functional tissues and organs –Nanomedicine and Biomaterials – identify novel developments in materials science and biomaterials leading to new drug s and improved devices –Trauma - develop materials, therapies, treatments, and diagnostics that will improve trauma treatment –Medical Logistics – transformational technologies applied to core logistics systems, focusing on devices, practices, and business processes to improve military medical logistics.

23. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Small Business Innovative Research (SBIR) & Small Business Technology Transfer (STTR) *Eligible companies submit proposals against a specific topic, which is prepared by a DoD subject-matter expert *Three Phase Process Phase I -startup phase, with awards up to $100,000 Phase II - up to $750,000,expand on Phase I results and explore commercialization potential Phase III - laboratory to the marketplace, no funds available for support *Solicitations are released only at specific times during the year. For more information: Small Business Administration’s (SBA) http://www.sbaonline.sba.gov/SBIR/indexsbir-sttr.html#sttr http://www.sbaonline.sba.gov/SBIR/indexsbir-sttr.html#sttr DoD SBIR/STTR program http://www.acq.osd.mil/osbp/sbir/overview/index.htm

24. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC AMEDD Advanced Medical Technology Initiative (AAMTI) AAMTI is an OTSG-funded program initiated in 1999. Each FY $5,000,000 in P8 funds are MIPRed/FADed to AMEDD facilities to enable technology demonstrations. The key objectives of the AAMTI are to: Demonstrate Advanced Medical Technologies and their Impact on Cost, Access and Quality of Care Provide Senior AMEDD Leadership with Medical Tech-Watch Capability Encourage Medical Technology Entrepreneurship by Funding AMEDD Technology Innovators

25. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Other Collaborative Opportunities Subject Matter Experts for proposal review and panel review boards. Job opportunities for graduates or PhD’s looking to work in the medical research arena. Partnering with existing projects as a subcontractor.

26. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Useful Websites TATRC - www.tatrc.orgwww.tatrc.org USAMRMC BAA 08-1 - www.usamraa.army.mil/pages/Baa- Paa/mrmcbaalist.cfm www.usamraa.army.mil/pages/Baa- Paa/mrmcbaalist.cfm USAMRMC Homepage https://mrmc.detrick.army.mil https://mrmc.detrick.army.mil AMEDD AAMTI Announcement - http://grants.tatrc.org/proposals http://grants.tatrc.org/proposals Grants.gov – http://www.grants.gov/http://www.grants.gov/ CDMRP - http://cdmrp.army.milhttp://cdmrp.army.mil

27. Telemedicine & Advanced Technology Research Center Cutting Edge Medical Technology TATRC Heather White DoD Research Specialist Office of Sponsored Programs ENG 329 Email: hwhite1@umbc.eduhwhite1@umbc.edu Phone: 410-455-3140