1. A simple solution to a painful problem Warning: the following presentation contains unpleasant photographs

2. The Anterior Cruciate Ligament (ACL) is one of the key factors stabilizing the knee joint sudden hyperextensions, hyperflexions, and twists of the knee may cause tears or even total rupture 80% of all tendon and ligament tears are in the ACL A Painful Problem…

3. Non-Surgical Physiotherapy 2 AutograftAllograft functional instability Inability to return to previous activity Risk of meniscus tears Invasive, time consuming Donor site morbidity, scarring, sensitivity Weakening of donor site Long healing time Availability problem  cost $15000-$40000 Disease transmission concerns (Hepatitis, HIV) Less durable Current Solutions ACL reconstruction 3

4. Market Status $1.5B potential market 9 350,000 ACL surgeries P.A. in the USA 4,CAGR 5% 5 Total cost of surgery Autograft - $7500-$15000 codes: CPT 29888 “Arthroscopically aided anterior cruciate ligament repair/augmentation or reconstruction.” ICD-9-CM 83.81 (harvesting) ICD-9-CM 81.45 (implantation) Allograft - $15000 and up (no code for the allograft itself) Average cost of implants (screws) $3365 6 per procedure Most patients have to pay considerable amounts out of pocket! 7,8

5. The Tavor Artificial Ligament A simple solution A load bearing element, having the mechanical strength, as well as fatigue and creep resistance, attached to a Titanium bone screw at the distal end, and an interference screw at the proximal end

6. Tavor artificial ligament advantages The patient - reducing pain involved in the harvesting procedure, improving aesthetic outcome (less scarring), preventing loss of movement potential, improving healing kinetics The physician- reducing procedure time at least 50% The hospital- reducing operation room time at least 50% The payer - reducing total procedure costs Professional sports clubs – reducing time for "back on the track" Military - minimizing healing period, reducing time for the soldier back to active status 10

7. ILSI BioMed 2008 Outstanding Project Award 1 st Prize

8. Thank You for your time