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Marlene Lorgen 1, Elisa Casadei 1, David Hazlerigg 1 and Sam Martin 1 1 School of Biological Sciences, University of Aberdeen 1.

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Presentation on theme: "Marlene Lorgen 1, Elisa Casadei 1, David Hazlerigg 1 and Sam Martin 1 1 School of Biological Sciences, University of Aberdeen 1."— Presentation transcript:

1 Marlene Lorgen 1, Elisa Casadei 1, David Hazlerigg 1 and Sam Martin 1 1 School of Biological Sciences, University of Aberdeen 1

2 ALEVIN SPAWNING ADULTS Atlantic Salmon Life Cycle Salt Water Fresh Water Parr-Smolt Transformation (PST)  Critical transformation from freshwater juvenile (PARR) to sea water adapted juvenile (SMOLT)  Controlled by active thyroid hormone (T3)  T3 availability determined by action of deiodinases (Dios)  Dios regulated by photoperiod in birds and mammals  Increased Dio2 causes increase in T3 2 Salt Water EGG SMOLT PARR FRY RETURNING ADULT

3 Dio Response to External Environment Brain Gill 3 Ancestral Dio2 2 Dio2a Dio2b Salinity Responsive Photoperiod Responsive DIFFERENTIAL FUNCTIONALIZATION Photoperiod, h Dio2a NO CHANGE Fresh Salt The Next Question: How do these 2 very similar genes respond to different signals? STAY TUNED! Thanks for your Attention S. salar Dio Gene Identification: Partial Dio Sequences Cloned S. salar Genome BLAST Dio1 Dio2a Dio2b Dio3a1 Dio3a2 Dio3b Show Response to External Environment SALMONID

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