2. TECNIS ® ZMB00 Optical characteristics Powersfrom +5 tp +34 D in 0.5 dioptre increment Diameter6 mm diameter of optic FormBiconvex aspherical anterior surface, diffractive posterior surface MaterialUV blocker water-repelling acrylic Refraction index1.47 Edge designProTEC ™. 360º capsular contact on 360º continuous Biometry US INTERFEROMETRY A-Constant118.8 119.4 Theoretical AC depth5.4 mm Surgeon Factor 1.68 mm Haptic characteristics Total lenght13 mm StylusC MaterialUV blocker water-repelling acrylic DesignSpecial haptics arrangement Recommended Insertion system One Series ™ Ultra Insertion System (DK7786 handpiece and 1VIPR30 cartridges)

3. TECNIS ® ZMB00 OUR STUDY WE PRESENT A STUDY WITH 70 TECNIS ZMB00 IMPLANTS THAT HAVE BEEN ANALYZED FOR: NEAR/FAR VA WITH AND WITHOUT POSTQX CORRECTION THROUGH TIME, TAKING MEASUREMENTS AT DAY 15, 30 AND 60.NEAR/FAR VA WITH AND WITHOUT POSTQX CORRECTION THROUGH TIME, TAKING MEASUREMENTS AT DAY 15, 30 AND 60. POSTCX (PELLI-ROBSON ® ) SENSITIVITY AT DAY 60. POSTCX (PELLI-ROBSON ® ) SENSITIVITY AT DAY 60. ADVERSE EFFECTS (DYSPHOTOPSIAS, HALOS, GLARE…).ADVERSE EFFECTS (DYSPHOTOPSIAS, HALOS, GLARE…). SUBJECTIVE EVALUATION BY PATIENT AND SURGEON OF NEAR AND FAR VA. SUBJECTIVE EVALUATION BY PATIENT AND SURGEON OF NEAR AND FAR VA.

4. TECNIS ® ZMB00 OUR STUDY The sample of the study comprised 70 patients, 28 male and 42 female, analyzing their first intervened eye. The mean age of the male group was 67 (±7) and the female group of 68 (±9). SEXMaleFemale CountCount Age group (years) < 60 28 60 - 70 1416 71- 80 1214 >8004 TOTAL2842

5. TECNIS ® ZMB00 FAR VISUAL ACUITY P<0.0001 (t test for paired samples) comparing UCVA/BCVA and their evolution in time. The implant produced in the sample an UCVA 0.84 ± 0.16 that allows non- dependency from spectacles.

6. TECNIS ® ZMB00 NEAR VISUAL ACUITY We analyzed the evolution of near visual acuity (corrected and uncorrected) in time for all patients in the sample. P<0.0001 there is a statistically significant difference in the comparison between the near VA in time, both for corrected and uncorrected VAs.

7. TECNIS ® ZMB00 ADVERSE EFFECTS 0G1G2G3 Days elapsedpercentage (%) Adverse effects15 days 71.4318.578.571.43 30 days 80.0015.712.861.43 60 days88.5710.001.430.00 Halos, disphotopsias, glare… Grading scale: No effects (0) Slight (G1) Moderate (G2) Severe (G3)

8. TECNIS ® ZMB00 FAR VA EVALUATION EVALUATION SCALE: VERY GOOD (G1) GOOD (G2) SUFFICIENT (G3) INSUFFICIENT (G4) Far vision evaluation (patient evaluation) PeriodG1G2G3G4 15 days3310261 30 days3821110 60 days422170 Far vision evaluation (surgeon e evaluation) PeriodG1G2G3G4 15 days 4213150 30 days 432520 60 days511900

9. TECNIS ® ZMB00 NEAR VA EVALUATION EVALUATION SCALE: VERY GOOD (G1) GOOD (G2) SUFFICIENT (G3) INSUFFICIENT (G4) Near vision evaluation (evaluation Paciente) PeriodG1G2G3G4 15 days 3318 1 30 days 3522130 60 days 521620 Near vision evaluation (evaluation Cirujano) PeriodG1G2G3G4 15 days 402640 30 days 392830 60 days541510

10. TECNIS ® ZMB00 CONTRAST SENSITIVITY (CSF) Count Contrast sensitivity MeanTypical deviation 21.580.11 151.600.11 531.640.10 Monocularly measured with Pelli-Robson after 60 days of surgery. CSF normality values: 60 years: 1.68-1.84* *J Cataract Refract Surg. 2001 Feb;27(2):261-6. Normal values for the Pelli-Robson contrast sensitivity test. Mäntyjärvi M. Laitinen T.Mäntyjärvi MLaitinen T

11. TECNIS ® ZMB00 CONCLUSIONS I 74.28% of intervened patients had far vision equal to 0.80 or above 60 days after the intervention. 74.28% of intervened patients had far vision equal to 0.80 or above 60 days after the intervention. 94.29% is reading J1 without correction 60 days after the intervention. 94.29% is reading J1 without correction 60 days after the intervention. 90% of patients are very satisfied with their far vision and 97.14% with the near vision acuity achieved (satisfaction questionnaires). None found it insufficient at any distance. 90% of patients are very satisfied with their far vision and 97.14% with the near vision acuity achieved (satisfaction questionnaires). None found it insufficient at any distance. Contrast sensitivity (CSF) was not affected by the implant, reaching values of 1.64 ± 0.10 in 75.71% of cases 60 days after surgery. Contrast sensitivity (CSF) was not affected by the implant, reaching values of 1.64 ± 0.10 in 75.71% of cases 60 days after surgery. Adverse effects (halos and flashes) disappear in most cases after 60 days. 88.57% had none and only 1.43% exhibited moderate effects. Adverse effects (halos and flashes) disappear in most cases after 60 days. 88.57% had none and only 1.43% exhibited moderate effects.

12. TECNIS ® ZMB00 CONCLUSIONS “IN THE ANALYSIS OF THE ZMB00 IOL, WITH HALF THE FOLLOW-UP TIME OF ITS PREDECESSOR THE ZM900 MODEL, WE FOUND SIMILAR OPTIC CHARACTERISTICS. “IN THE ANALYSIS OF THE ZMB00 IOL, WITH HALF THE FOLLOW-UP TIME OF ITS PREDECESSOR THE ZM900 MODEL, WE FOUND SIMILAR OPTIC CHARACTERISTICS. WE ARE WAITING TO PERFORM VA MEASUREMENTS IN MIDDLE DISTANCE AS WELL AS THE 150-DAY FOLLOW-UP AND REFRACTIVE ADJUSTMENTS FOR PATIENTS WHO MAY NEED IT”