1. Workpackage 4 Malmö, 8 January 2010

2. Overview Objectives Year 2 Progress Year 2 Planning Year 3

3. Objectives Yr 2 ObjectiveDeliv./Milest.Status WP4.1Phantom scanning (MSCT-CBCT-µCT) D4.2 WP4.1In vitro accuracy measurements M4.3On-going WP4.2Extension of dataset No D/MOn-going WP4.3Recruitment implant placement M4.4 WP4.3Recruitment impacted canines No D/MOn-going WP4.3Recruitment impacted 3rd molars No D/M WP4.3Recruitment sinus grafts No D/MOn-going

4. Progress Yr 2 ObjectiveDeliv./Milest.Status WP4.1 Phantom scanning (MSCT-CBCT-µCT) D4.2 WP4.1In vitro accuracy measurements M4.3On-going WP4.2Extension of dataset No D/MOn-going WP4.3Recruitment implant placement M4.4Achieved WP4.3Recruitment impacted canines No D/MOn-going WP4.3Recruitment impacted 3rd molars No D/MAchieved WP4.3Recruitment sinus grafts No D/MOn-going

5. WP4.1 Phantom scanning Subsection# phantoms# CBCT# settingsGold S Segmentation accuracy Surface394 – 15MSCT + µCT Internal4121µCT Linear accuracy 3120DM Diagnostic accuracy Bone lesions1061DM Root lesions1061DM

6. Objectives Yr 2 ObjectiveDeliv./Milest.Status WP4.1Phantom scanning (MSCT-CBCT-µCT)D4.2 WP4.1 In vitro measurementsM4.3 On- going WP4.2Extension of datasetNo D/MOn-going WP4.3Recruitment implant placementM4.4 WP4.3Recruitment impacted caninesNo D/MOn-going WP4.3Recruitment impacted 3rd molarsNo D/M WP4.3Recruitment sinus graftsNo D/MOn-going

7. WP4.1 In vitro measurements Segmentation accuracy –Surface –Trabecular structure

8. WP4.1 In vitro measurements Linear accuracy –kV, mA, vox (n = 20) –Distance CEJ-bone –Observer software

9. WP4.1 In vitro measurements Diagnostic accuracy –Bone lesions n = 10x3 - 6 CBCT - 6 ob % corr x size x CBCT

10. WP4.1 In vitro measurements Diagnostic accuracy –Root lesions n = 10 – 6 CBCT – 6 ob % corr x param. x CBCT prelim.

11. Objectives Yr 2 ObjectiveDeliv./Milest.Status WP4.1Phantom scanning (MSCT-CBCT-µCT)D4.2 WP4.1 In vitro measurementsM4.3On-going WP4.2 Extension of datasetNo D/M On- going WP4.3Recruitment implant placementM4.4 WP4.3Recruitment impacted caninesNo D/MOn-going WP4.3Recruitment impacted 3rd molarsNo D/M WP4.3Recruitment sinus graftsNo D/MOn-going

12. WP4.2 Animal model D4.1 OK Yr 1 Extention of dataset Img KUL: + 3 CBCT Data analysis 7 ob

13. Objectives Yr 2 ObjectiveDeliv./Milest.Status WP4.1Phantom scanning (MSCT-CBCT-µCT)D4.2 WP4.1 In vitro measurementsM4.3On-going WP4.2 Extension of datasetNo D/MOn-going WP4.3 Recruitment implant patients M4.4 WP4.3Recruitment impacted caninesNo D/MOn-going WP4.3Recruitment impacted 3rd molarsNo D/M WP4.3Recruitment sinus graftsNo D/MOn-going

14. WP4.3Clinical studies Recruitment implant patients –n = 40 –Infopre-surg peri-surg post-surg

15. Objectives Yr 2 ObjectiveDeliv./Milest.Status WP4.1Phantom scanning (MSCT-CBCT-µCT)D4.2 WP4.1 In vitro measurementsM4.3On-going WP4.2 Extension of datasetNo D/MOn-going WP4.3 Recruitment implant patientsM4.4 WP4.3 Recruitment impacted canines No D/M On- going WP4.3Recruitment impacted 3rd molarsNo D/M WP4.3Recruitment sinus graftsNo D/MOn-going

16. WP4.3Clinical studies Recruitment impacted canines –n = 7 –Infopre-surg peri-surg post-surg –Recruitment rate low

17. Objectives Yr 2 ObjectiveDeliv./Milest.Status WP4.1Phantom scanning (MSCT-CBCT-µCT)D4.2 WP4.1 In vitro measurementsM4.3On-going WP4.2 Extension of datasetNo D/MOn-going WP4.3 Recruitment implant patientsM4.4 WP4.3 Recruitment impacted caninesNo D/MOn-going WP4.3 Recruitment impacted 3rd molars No D/M WP4.3Recruitment sinus graftsNo D/MOn-going

18. WP4.3Clinical studies Recruitment impacted 3rd molars –n = 54 –Infopre-surg peri-surg post-surg

19. Objectives Yr 2 ObjectiveDeliv./Milest.Status WP4.1Phantom scanning (MSCT-CBCT-µCT)D4.2 WP4.1 In vitro measurementsM4.3On-going WP4.2 Extension of datasetNo D/MOn-going WP4.3 Recruitment implant patientsM4.4 WP4.3Recruitment impacted caninesNo D/MOn-going WP4.3Recruitment impacted 3rd molarsNo D/M WP4.3 Recruitment sinus grafts No D/M On- going

20. WP4.3Clinical studies Recruitment sinus grafts –n = 4 –Recruitment rate low

21. Planning Yr 3 Priority: rounding up recruitment Data analysis clinical studies –Ongoing in both centers –Visiting researchers Report writing –Priority in vitro studies

22. M4.1Skull phantoms delivered (m12) M4.2Report animal study (m12) M4.3Report phantom study (m18) M4.4Oral implants (m24) M4.5Report in vitro studies (m28) M4.6Other clinical studies (m30) M4.7WP4 completed (m36) D4.1Animal study completed (m12) D4.2Phantom models scanned (m18) D4.3In vitro studies report (m28) D4.4Diagnostic accuracy report (m36)