1. Assessing effects of prenatal PAH exposure on birth outcomes and neurocognitive development among a cohort of Polish mothers and newborns. Ulka Bawle*, Wieslaw Jedrychowski**, Robin Whyatt*, David Camann***, John Spengler***, Tom Dumyahn***, Frederica Perera* */ Center for Children’s Environmental Health, Columbia University, New York, USA **/Chair of Epidemiology and Preventive Medicine, Coll.Med.. Jagiellonian University, Krakow, Poland ***/

2. What is the role of early life exposures to PAH?

3. D - Developmental C - Cancer G - Genetic damage

4. PAHsEpoxides Macromolecules DNA Biotransformation Mixed-function oxidases P-450 enzymes Aryl hydrocarbon hydrolase (AHH) HEALTH HAZARDS DUE TO PAH COMPONENTS Impairment of fetal and early childhood growth and development

6. Research Design of study “Vulnerability of the Fetus/Infant to PAH, PM 2.5 and ETS” Recruitment in Pregnancy I tri. II tri. III tri. Deli- 3 m 6 m 9 m 12 m n=96 n=400 very

8. Characteristics of recruited pregnant women: age of women N = 30 N = 105

9. Characteristics of recruited pregnant women: by educational level and marital status N = 30 N = 105

10. Characteristics of recruited pregnant women: number of pregnancies N = 30 N = 105

12. PAH concentrations in low and high polluted areas of Krakow (N=30). Air monitoring over 48 hours. ng/m3

13. PM 2.5 concentration in Krakow N = 30 14,652(Q3-Q1)/2 26,181Standard deviation 56,758Median 56,729Mean

14. PAH concentrations in Krakow and New York City ng/m3

15. Contribution of various chemical substances (in %) in the total PAH concentration in Krakow and New York City Krakow New York City