1. Updated School TB Screening Policy Frank Alvarez, MD, MPH and Pamina Bagchi, MPH Los Angeles County Department of Public Health Tuberculosis Control Program

2. Topics Background Data Myth-Busting New Approach Questions

3. Introduction In 1980, amended California Administrative Code, Title 22, Division 22, Chapter 9, Sections 41301-41329 to enable the Local Health Officer to mandate tuberculosis (TB) testing of school children, if deemed necessary, for that specific jurisdiction.

4. Introduction (2) From 1985-2011, the TB Control Program has required all kindergartners and students who have never previously attended school in California to provide written documentation of a TB skin test (or IGRA) result.

5. Purpose of Previous Pre-K TB Testing Requirement To collect County-wide data to assess improvement in TB control and better understand the presence of TB infection and disease To determine the impact of immigration patterns on local TB incidence

6. Purpose of Previous Pre-K TB Testing Requirement (2) To identify children who are candidates for treatment of latent TB infection (LTBI) To measure annual TB infection rates in the school-aged population

7. 7 TB Skin Test Results Among New School Entrants (K-12) and TB Cases (4-18 year old) in Los Angeles County 1993-2009 Number of TB Cases% of TST (+)

8. Myth 1 About TB Myth: Being infected with TB (positive skin test or blood test) means you have active TB disease. Fact: Infection does not necessarily mean disease.

9. Myth 2 About TB Myth: TB testing is the same as TB screening. Fact: Testing for TB is not the same as screening. TB ScreeningTB Testing Risk assessment (series of questions) performed by clinician Skin test (TST) or blood test (QFT or T-Spot) If deemed higher risk, test for TB infection is done If positive, then chest x-ray is done

10. Myth 1 About Previous Testing Requirement Myth: The Pre-K Testing Requirement was used as a method of finding children with active TB disease. Fact: The requirement was designed to determine / monitor TB infection rates, NOT to find and treat active TB disease cases. TB Control utilizes contact investigations to find active TB cases of all ages.

11. Myth 2 About Previous Testing Requirement Myth: The Pre-K Testing Requirement was an effective means of getting TB-infected children treated. Fact: Monitoring was not in place to ensure that children who tested positive for TB infection began treatment. Evidence suggests that many who did begin treatment did not complete the full treatment regimen.

12. Myth 3 About Previous Testing Requirement Myth: If the requirement were not in place, there would be a rise in pediatric TB cases in LA County. Fact: Jurisdictions that either rescinded their Pre-K Testing Requirement, like Riverside County, or that never had a Pre-K Testing Requirement, like San Diego County, have continued to see a steady decline in pediatric TB cases.

13. New Requirement Rescind the testing requirement for children entering kindergarten or a California school for the first time. Incorporate universal TB screening and risk- based testing in existing California State physical examination requirement for children entering first grade.

14. New Requirement (2) Health providers, as part of this routine health assessment, will screen students and test them for TB only if a risk factor is present.

15. New Requirement (3) Old PolicyNew Policy Screening for High Risk NoneAll Students TB TestingAll Students Only those at high risk Additional Office Visits Needed? Likely Not likely (same as physical exam) When? Entering Kindergarten Entering First grade 5

16. Factors to Assess High Risk for TB If any of these is “Yes”  TST or IGRA Birth outside US in high-prevalence region Travel to high-incidence country > 1 week 16

17. Factors to Assess High Risk for TB (2) If any of these is “Yes”  TST or IGRA Contact with confirmed or suspected TB case Family member with positive TST

18. Why the Change? To promote evidence-based best practice, as recommended by the CDC, AAP, USPSTF, etc. To avoid redundancy and prevent fragmented care To prevent false positive children from receiving treatments that may harm their livers

19. Why the Change? (2) To focus on placing children in medical homes To focus on more effective interventions (e.g. CI) To focus on higher-risk populations (e.g. homeless)

20. Partners Los Angeles County Office of Education (LACOE) Los Angeles Unified School District (LAUSD) American Academy of Pediatrics, Local Chapter (AAP) American Academy of Family Practice, Local Chapter (AAFP) Los Angeles County Medical Association (LACMA) American Lung Association in California (ALAC)

21. Partners (2) Child Health and Disability Prevention (CHDP) Maternal, Child and Adolescent Health (MCAH) Los Angeles County Department of Health Services (DHS) CA Department of Public Health, TB Control Branch (TBCB) Long Beach Department of Health, Human Services (LBHHS) Long Beach Unified School District (LBUSD)

22. For Information on IGRAs Cellestis, a Qiagen Company (QuantiFERON Gold In-Tube) Nancy Hyland nhyland@cellestis.com (661)289-2557 Oxford Immunotec (T-SPOT) Deneen Jackson djackson@oxfordimmunotec.com (619)887-6109

23. TB Control Program Website

25. Questions? LA County TB Control Program Website www.publichealth.lacounty.gov/tb/ Chhandasi Pamina Bagchi, MPH Policy and Planning, TB Control Program cbagchi@ph.lacounty.gov (213) 745-0836 www.publichealth.lacounty.gov/tb/ cbagchi@ph.lacounty.gov