1. Towards a Flexible Integration of Clinical Guideline Systems With Medical Ontologies and Medical Information Systems Gianluca Correndo 1, Paolo Terenziani 2 1 DI, Università di Torino, Corso Svizzera 184, 10149 Torino, Italy 2 DI, Univ. Piemonte Orientale “A. Avogadro”, Spalto Marengo 33, Alessandria, Italy

2. Outline Need for data integration Knowledge Sharing Guideline standardization External ontology integration GLARE proposal Translation Services Comparisons

3. Need for Data Integration DB GLARE Execution Environment Clinical Guideline Patients’ Data If ECG is altered for patient then … SELECT exam FROM … WHERE …

4. Knowledge Sharing a b a) Centralized View: One Ontology Every IS adheres to it b) Decentralized View: Different Ontologies Every IS particularize its data access in order to adhere to the choosed ontology

5. Guidelines Standardization SNOMED UMLS ICD-9...... GLAREDifferent Standard Vocabularies Different IS

6. External Ontology Integration Mapping #2 Domain Ontology #2 General DB concepts DB Domain Ontology #1 DB Ontology Mapping #1 Particular DB description

7. Knowledge Sharing SNOMED UMLS ICD-9 a b Information System a Information System b Personal DB Ontology

8. GLAREs’ Proposal Clinical DB Acquisition Patient DB Execution Instance DB Acquisition Interface Execution Interface CGL DB XML Expert Physician User Physician XML DBMS System KIS Browser Module Metadata Extraction Module Mapping Query Compiler Medical Ontology DB Ontology

9. Mapping Services HL7 DB Coding System HL7 Domain Coding System DB Upper DB Ontology Domain Ontology HL7 Code System Translation API Description Logic HL7 API Applicative Data

10. Comparisons VMR SAGE GLARE Common Ontology

11. Comparisons VMR SAGE GLARE Common Ontology VMR