1. Filling and Loading Station TECHNICALS CARACTERISTICS CAPACITY OF TANK : 25 Kg MANUFACTURER : NEU YEAR 1996 N° OF FABRICATION : 812.K5/8.943 POWER SUPPLY : 3 X 400 VAC + PE - 50 Hz SIEMENS 135u PLC ACCURACY TOLERANCE : +/- 1%

2. Solution Preparation TECHNICALS CARACTERISTICS TANK CAPACITY 175 litres TANK WORKING CAPACITY : 150 LITRES MANUFACTURER : CELLIER YEAR 1994 POWER SUPPLY : 3 X 400 VAC + PE - 50 Hz SPEED SCAPER AGITATOR : 12 à 24 tr/min SPEED HOMGENISER : 1500 à 3000 tr/min For more information see PDF file joint

3. High Shear Mixer Gral 600 TYP : GRAL 600 YEAR : 1996 MANUFACTURER : MACHINES COLLETTE NV SERIAL NUMBERS : 93GRI06000031 THE GRAL 600 IS A HIGH SHEAR MIXER GRANULATOR THAT IS ABLE TO : GRANULATE PRODUCTS DISCHARGING POWDER FROM IBC MATCON DRY MIXING SAMPLING OF PURIFIED WATER WET MIXING MIXING BY ADDITION OF PURIFIED WATER GRANULATION UNLOADING WET GRANULES THROUGH A WET MILL TECHNICALS CARACTERISTICS WEIGHT : 3950 kg SUPPLY POWER : 3 x 400V, 50 Hz, 125A ENPOINT MAX : 50 kW TOTAL WATER QUANTITY : 0- 100 kg MIXER TIME : 0 –30000 sec ALL PARTS OF THE MIXER-GRANULATOR IN CONTACT WITH THE PRODUCT ARE MADE OF STAINLESS STEEL GRADE 316L BOWL TOTAL VOLUME : 600 LITRES PROCESS BATCHES :min 200 – max 500 LITRES OF POWDER

5. Intermediate Bulk Container PHARMATECH TYP : GF YEAR : 1994 MANUFACTURER : PHARMATECH NUMBERS : 15

6. FLUID BED GRANULATION MANUFACTURER : GLATT AG TYPE : WST-CD 120 - BD YEAR 1996 AUTOMAT SIEMENS S5 VOLTAGE SUPPLY : 3 X 400V – 50 Hz POWER : 57.5 kW CAPACITY TANK : 500 LITERS WEIGHT : 2800 kg SWITCH CABINET

7. PRODUCT FILTER HOUSING DIAMETER : 1800 mm NUMBER OF FILTER : 4 X WSG-15-S FILTER DIAMETER : 550 mm FILTER AREA : 16 m2 (4 x 4) FILTER TYP : PA/CF 5 µ, ANTISTATIC 4 Filterchambers with separete Filters

8. INLET AIR HANDLIG UNIT FILTER OUTPUT FILTER : QUALITY PES9373 PRIMARY FILTER : QUALITY EU4 / BAG FILTER INTERMEDIATE FILTER : QUALITY EU 8/9 / BAG FILTER FINE FILTER : QUALITY HEPA 12 / BOX FILTER FROST PROTECTION HEATER AIR VOLUME : 7000 m3/h MAIN HEATER STEAM PRESSURE : 3 BAR STEAM COMSUPTION : 428 kg/h TEMPERATURE RANGE : -0/ +100 °C HEAT RATING : 895,230 Kj/h FOREEZE PROTECTION HEATER TEMPERATURE RANGE : -30/ +70 °C STEAM CONSUMPTION : 107 kg/h HEAT RATING : 213,150 Kj/h

10. OUTLET AIR HANDLING (FILTER POLICE) FILTER TYP : ANTISTATIC FLOW : 7,000 m3/h FIRST LEVEL : QUALITY EU7 - QUANTITY 3 SECOND LEVEL : QUALITY EU12 - QUANTITY 3

11. OUTLET AIR FAN WEIGHT : 700 kg AIR VOLUME : 7000 m3/h STATIC PRESSURE : 125 mbar POWER : 45 KW VOLTAGE SUPPLY : 3 x 400V – 50Hz MOTOR SPEED : 2,940 urpm CIP SYSTEM (CLEAN IN PLACE) HEAT EXCHANGER : TYP PLATE HEAT EXCHANGER STEAM PRESSURE : 3 bar STEAM COMSUPTION : 2,059 kg/h PUMP : 11 kW VOLTAGE SUPPLY : 3 x 400V – 50Hz PURIFIED WATER COMSUPTION : 8,8 m3/h NOZZLES COMSUPTION : STATIC NOZZLE : 6 x 90 LITERS PER MINUTES = 360 lts/min DYNAMIC NOZZLE : 7 x 40 LITERS PER MINUTES = 280 lts/min

12. ENERGY DEMAND COMPRESSED AIR MIN PRESSURE : 5.5 BAR (90 psi) MIN PRESSURE : 10 BAR (150 psi) CIP COMPSUTION : 150 m3/h FLUID BED COMPSUTION : 25 m3/h COMPRESSOR NEED : 150 m3/h QUALITY : WITHOUT OIL AND WATER STEAM AT 3 BAR (143.5°C) CIP COMPSUPTION : 2,059 kg/h HEATER COMSUPTION : 535 kg/h MAX : 2,059 kg/h PURIFIED WATER CIP COMPSUPTION : 28.8 m3/h AT 2 BAR POWER FAN UNITY : 45.0 kW CIP PUMP : 11.0 Kw SWITCH : 1.5 Kw MAX : 57.5 kW

13. WEIGHT FLUID BED : 2,800 kg OUTLET AIR FAN : 700 kg POWER CABINET : 300 kg SWITCH CABINET : 200 kg POLICE FILTER : 600 kg QUICK ACTION STOP VALVE DN 500 : 200 kg

14. Final Sieving TECHNICALS CARACTERISTICS CAPACITY TO DISCHARGE A 600 LITRE IBC CONTAINING 180 Kg OF GRANULES IN A CONTROLLED AND CONSISTENT MANNER IN TIMES BETWEEN 15 AND 45 MINUTES. MANUFACTURER : KEMUTEC YEAR 1994 MATERIAL OF CONSTRUCTION : 316 STAINLESS STEEL FOR ALL PRODUCT CONTACT PARTS SERVICE REQUIREMENTS : 1.DRIED AIR AT 6 BAR 2.SINGLE PHASE ELECTRICAL AT 220-240 V AND 50 CYCLES/SECOND.

15. PHARMALIFT BLENDER TYP : SL406 YEAR : 1994 MANUFACTURER : SERVOLIFT THE IBC BLENDER IS A HYDRAULICALLY POWERED MACHINE FOR CLAMPING LIFTING AND ROTATING AN IBC FULL OF POWDER GRANULES TECHNICALS CARACTERISTICS COLUMN WEIGHTS APPROX : 900 kg SUPPLY POWER : 3 x 400V, 50 Hz, 11 KW (4 WIRE – NO NEUTRAL) SPEED RANGE : 5 18 rpm TIME RANGE : 0 – 999 s FREQUENCY OF BLEND : AVERAGE FREQUENCY OF 1 PER HOUR (8 PER 8 HOUR DAY) CAPACITY FOR THE LIFTING AND BLENDING : 1200 LITERS COMPRESSED AIR : 6.9 BARS 3200 mm

16. PANEL A (TO CONTROL CLAMPING FUNCTIONS) PANEL B LAUER INTERFACE (TO CONTROL BLENDING FUNCTIONS) ELECTRICAL CABINET

17. HYDRAULIC POWER UNIT COLUMN