1. Slide 1 Presented By Susan Chang at 2014 ASCO Annual Meeting

2. Imaging assessment in Neuro-Oncology Presented By Susan Chang at 2014 ASCO Annual Meeting

3. Limitation: Early Pseudo-Progression after radiochemotherapy Presented By Susan Chang at 2014 ASCO Annual Meeting

4. Slide 4 Presented By Susan Chang at 2014 ASCO Annual Meeting

5. Limitation- Determination of enhancing and non- enhancing tumor burden post antiangiogenic treatment Presented By Susan Chang at 2014 ASCO Annual Meeting

6. Slide 6 Presented By Susan Chang at 2014 ASCO Annual Meeting

7. # 2007 Validation of RANO Criteria: Contribution of T2/FLAIR Assessment in Patients with Recurrent Glioblastoma Treated with Bevacizumab- Huang et al Presented By Susan Chang at 2014 ASCO Annual Meeting

8. Assessment of RANO Presented By Susan Chang at 2014 ASCO Annual Meeting

9. RANO-Endpoints and Trial Design Presented By Susan Chang at 2014 ASCO Annual Meeting

10. # 2005- Final Results of APG101_CD_002: APG101 + Reirradiation versus Reirradiation in the Treatment of Patients with Progressive Glioblastoma: Platten et al Presented By Susan Chang at 2014 ASCO Annual Meeting

11. Results Presented By Susan Chang at 2014 ASCO Annual Meeting

12. APG101_CD_002: Novel Biomarker for OS Presented By Susan Chang at 2014 ASCO Annual Meeting

13. Slide 13 Presented By Susan Chang at 2014 ASCO Annual Meeting

14. Slide 14 Presented By Susan Chang at 2014 ASCO Annual Meeting

15. Slide 15 Presented By Susan Chang at 2014 ASCO Annual Meeting

16. Results for ICT-107 Ph II Presented By Susan Chang at 2014 ASCO Annual Meeting

17. Authors conclusions/Comments Presented By Susan Chang at 2014 ASCO Annual Meeting

18. Authors conclusions/Comments Presented By Susan Chang at 2014 ASCO Annual Meeting

19. What “success” in a phase II trial warrants phase III evaluation? Presented By Susan Chang at 2014 ASCO Annual Meeting

20. Future RANO efforts Presented By Susan Chang at 2014 ASCO Annual Meeting

21. Acknowledgements Presented By Susan Chang at 2014 ASCO Annual Meeting