Presentation on theme: "Circulatory Systems Take a look at a skeleton and see how well a heart is protected — open heart surgery takes breaking a body to get to the heart. 2008-2009."— Presentation transcript:
1 Circulatory SystemsTake a look at a skeleton and see how well a heart is protected — open heart surgery takes breaking a body to get to the heart.
3 Exchange of materialsAnimal cells exchange material across their cell membranefuels for energynutrientsoxygenwaste (urea, CO2)If you are a 1-cell organism that’s easy!diffusionIf you are many-celled that’s harder
4 Overcoming limitations of diffusion Diffusion is not adequate for moving material across more than 1-cell barrieraaCO2NH3O2CHCHOaaO2CHCHOCO2aaNH3CHOCHO2aa
5 In circulation… What needs to be transported nutrients & fuels from digestive systemrespiratory gasesO2 & CO2 from & to gas exchange systems: lungs, gillsintracellular wastewaste products from cellswater, salts, nitrogenous wastes (urea)protective agentsimmune defenseswhite blood cells & antibodiesblood clotting agentsregulatory moleculeshormones
6 BLOOD!!! What is it good for???? 55% of blood volume = plasma45% of blood volume = cells, plateletsERYTHROCYTES (rbc’s)Last about 120 daysNo organelles!Produced in red bone marrow, sternum, ribs, some long bones“old” rbc’s removed by spleen and liverHemoglobin on rbc’s is what carries O2 -> lack of hemoglobin = anemiaEach rbc has 280 million molecules of hemoglobin. How many hem. mol. in your body if have 5 million rbc’s per mL of bloodand usually have body volume of 5L?<-MATH ATTACK!
7 BLOOD, cont.Leukocytes (wbc’s)Immunity!TWO TYPES:Granular (produced in bone marrow)*Neutrophils (most abundant) – phagocytic*Eosinophils – allergic reactions*Basophils – allergic reactions (histamines)Agranular*Lymphocytes – produce antibodies*Monocytes (largest WBC) – phagocyticLEUKEMIA = cancer of wbc’s (overabundance of wbc’s – leads to weakness/impaired clotting)
8 Never Let Monkeys Eat Bananas!!! NeutrophilsLymphocytesMonocytesEosinophilsBasophils
9 Circulatory systems All animals have: circulatory fluid = “blood” tubes = blood vesselsmuscular pump = heartopenclosedhemolymphblood
10 Open circulatory system Taxonomyinvertebratesinsects, arthropods, mollusksStructureno separation between blood & interstitial fluidhemolymphThe fact that open and closed circulatory systems are each widespread among animals suggests that both offer advantages. For example, the lower hydrostatic pressures associated with open circulatory systems make them less costly than closed systems in terms of energy expenditure. Furthermore, because they lack an extensive system of blood vessels, open systems require less energy to build and maintain. And in some invertebrates, open circulatory systems serve a variety of other functions. For example, in molluscs and freshly molted aquatic arthropods, the open circulatory system functions as a hydrostatic skeleton in supporting the body.
11 Closed circulatory system Taxonomyinvertebratesearthworms, squid, octopusesvertebratesStructureblood confined to vessels & separate from interstitial fluid1 or more heartslarge vessels to smaller vesselsmaterial diffuses between blood vessels & interstitial fluidclosed system = higher pressuresWhat advantages might be associated with closed circulatory systems? Closed systems, with their higher blood pressure, are more effective at transporting circulatory fluids to meet the high metabolic demands of the tissues and cells of larger and more active animals. For instance, among the molluscs, only the large and active squids and octopuses have closed circulatory systems. And although all arthropods have open circulatory systems, the larger crustaceans, such as the lobsters and crabs, have a more developed system of arteries and veins as well as an accessory pumping organ that helps maintain blood pressure. Closed circulatory systems are most highly developed in the vertebrates.
12 Vertebrate circulatory system Adaptations in closed systemnumber of heart chambers differs234high pressure & high O2 to bodylow pressure to bodylow O2 to bodyWhat’s the adaptive value of a 4 chamber heart?4 chamber heart is double pump = separates oxygen-rich & oxygen-poor blood; maintains high pressure
13 Evolution of vertebrate circulatory system fishamphibianreptilesbirds & mammals2 chamber3 chamber3 chamber4 chamberBirds AND mammals!Wassssup?!A powerful four–chambered heart was an essential adaptation in support of the endothermic way of life characteristic of mammals and birds. Endotherms use about ten times as much energy as equal–sized ectotherms; therefore, their circulatory systems need to deliver about ten times as much fuel and O2 to their tissues (and remove ten times as much CO2 and other wastes). This large traffic of substances is made possible by separate and independent systemic and pulmonary circulations and by large, powerful hearts that pump the necessary volume of blood. Mammals and birds descended from different reptilian ancestors, and their four–chambered hearts evolved independently—an example of convergent evolution.Why is it an advantage to get big?Herbivore: can eat more with bigger gut.lowers predation(but will push predators to get bigger as well, although no one east elephant s.)VAAAAAAAVVVVV
14 Evolution of 4-chambered heart Selective forcesincrease body sizeprotection from predationbigger body = bigger stomach for herbivoresendothermycan colonize more habitatsflightdecrease predation & increase prey captureEffect of higher metabolic rategreater need for energy, fuels, O2, waste removalendothermic animals need 10x energyneed to deliver 10x fuel & O2 to cellsconvergent evolution
15 Vertebrate cardiovascular system Chambered heartatrium = receive bloodventricle = pump blood outBlood vesselsarteries = carry blood away from heartarteriolesveins = return blood to heartvenulescapillaries = thin wall, exchange / diffusioncapillary beds = networks of capillariesArteries, veins, and capillaries are the three main kinds of blood vessels, which in the human body have a total length of about 100,000 km.Notice that arteries and veins are distinguished by the direction in which they carry blood, not by the characteristics of the blood they contain. All arteries carry blood from the heart toward capillaries, and veins return blood to the heart from capillaries. A significant exception is the hepatic portal vein that carries blood from capillary beds in the digestive system to capillary beds in the liver. Blood flowing from the liver passes into the hepatic vein, which conducts blood to the heart.
17 Arteries: Built for high pressure pump thicker wallsprovide strength for high pressure pumping of bloodnarrower diameterelasticityelastic recoil helps maintain blood pressure even when heart relaxes
18 Veins: Built for low pressure flow Blood flowstoward heartVeinsthinner-walledwider diameterblood travels back to heart at low velocity & pressurelower pressuredistant from heartblood must flow by skeletal muscle contractions when we movesqueeze blood through veinsvalvesin larger veins one-way valves allow blood to flow only toward heartOpen valveClosed valve
19 Capillaries: Built for exchange very thin wallslack 2 outer wall layersonly endotheliumenhances exchange across capillarydiffusionexchange between blood & cells
20 Controlling blood flow to tissues Blood flow in capillaries controlled by pre-capillary sphincterssupply varies as blood is neededafter a meal, blood supply to digestive tract increasesduring strenuous exercise, blood is diverted from digestive tract to skeletal musclescapillaries in brain, heart, kidneys & liver usually filled to capacityWhy?sphincters opensphincters closed
21 Exchange across capillary walls LymphaticcapillaryFluid & solutes flows out of capillaries to tissues due to blood pressure“bulk flow”Interstitial fluid flows back into capillaries due to osmosisplasma proteins osmotic pressure in capillaryBP > OPBP < OPInterstitialfluidWhat about edema?About 85% of the fluid that leaves the blood at the arterial end of a capillary bed reenters from the interstitial fluid at the venous end, and the remaining 15% is eventually returned to the blood by the vessels of the lymphatic system.Bloodflow85% fluid returns to capillariesCapillary15% fluid returns via lymphArterioleVenule
22 Lymphatic system Parallel circulatory system transports white blood cellsdefending against infectioncollects interstitial fluid & returns to bloodmaintains volume & protein concentration of blooddrains into circulatory system near junction of vena cava & right atrium
23 Lymph system Production & transport of WBCs Traps foreign invaders lymph vessels(intertwined amongst blood vessels)lymph node
24 Mammalian circulation systemicMammalian circulationpulmonarysystemicWhat do blue vs. red areas represent?
25 Mammalian heartto neck & head & armsCoronary arteries
27 Heart valves 4 valves in the heart Atrioventricular (AV) valve SLHeart valves4 valves in the heartflaps of connective tissueprevent backflowAtrioventricular (AV) valvebetween atrium & ventriclekeeps blood from flowing back into atria when ventricles contract“lub”Semilunar valvesbetween ventricle & arteriesprevent backflow from arteries into ventricles while they are relaxing“dub”The heart sounds heard with a stethoscope are caused by the closing of the valves. (Even without a stethoscope, you can hear these sounds by pressing your ear tightly against the chest of a friend—a close friend.) The sound pattern is “lub–dup, lub–dup, lub–dup.” The first heart sound (“lub”) is created by the recoil of blood against the closed AV valves. The second sound (“dup”) is the recoil of blood against the semilunar valves.
28 Lub-dub, lub-dub Heart sounds Heart murmur closing of valves “Lub” recoil of blood against closed AV valves“Dub”recoil of blood against semilunar valvesHeart murmurdefect in valves causes hissing sound when stream of blood squirts backward through valveSLAVAV
29 With every beat of your heart…. Watch me go!SA (Sinoatrial) node (pacemaker) = in wall of right atrium – when this fires, action potential spreads to both atria via gap junctions in intercalated discsAV (Atrioventricular) node = in lower right atrium – acts as delay/relay – sends message to ventricles to contractCardiac center in medulla communicates with heart to regulate (hormones can speed up/slow down)
30 What actually kills women???? “Issues of the heart”What actually kills women????What Women Think The Facts60% Cancers 35% Heart disease19% Heart disease 23% All cancers13% Don’t know (4% breast)4% Other causes 20% Other causes2%Stress 8% Strokes1% Old age 4% Pulmonary dis.1% Smoking 4% Pneumonia/flu3% Accidents3% Diabetes
31 Issues of the heart cont. Heart murmur – improper closing of heart valve(s) – can lead to need for repair/replacementCardiomegaly – enlarged heart – ranges from mild to severe (need for replacement)“hole in heart” – improper closing of septum between L and R ventricles (open before birth b/c babies don’t need lungs until born) – foramen ovaleHypoplasia – only one side of heart functions properlyBrugada Syndrome – sudden cardiac death – irregular heart rhythms (genetic)Mitral stenosis – narrowing of mitral valve – decreased blood flow to bodySO MANY MORE -CHECK THEM OUT
32 fill (minimum pressure) Cardiac cycle1 complete sequence of pumpingheart contracts & pumpsheart relaxes & chambers fillcontraction phasesystoleventricles pumps blood outrelaxation phasediastoleatria refill with bloodsystolic________diastolicpump (peak pressure)_________________fill (minimum pressure)110____70
33 Measurement of blood pressure High Blood Pressure (hypertension)if top number (systolic pumping) > 150if bottom number (diastolic filling) > 90