Slide 8 of 34 We are now part of an early radical biological revolution that will dwarf the industrial revolution. -- Julian Savulescu (Oxford University)
Slide 9 of 34 Futurama Last year – Juan Enriquez video Now it is outdated
Slide 10 of 34 21 st Century Therapies Gleevec – Chronic Myelogenous Leukemia 1 pill a day Sprycel & Tasigna BrCa-1 and BrCa-2 gene tests for breast and ovarian cancer In 2010, Oncept DNA Vaccine Canine Oral Melanoma Transdermal application June 2010, siRNA Cure for Ebola? (Geisbert et al.)
Slide 11 of 34 Venter Institute August 2009 – 1 st Genetically Engineered Organism Altered Yeast genome bacterium May 2010 – Four bottles (ACTG) + signals = Fully functional Mycoplasma mycoides genome Not just engineering bacteria, but creating them
Slide 12 of 34 http://ung.igem.org/Team_List?year=2011 http://2011.igem.org/Main_Page
Slide 13 of 34 Tracheal Replacement Lab made organ implanted for first time Trachial Cancer patient Not tissue derived from patient, entirely foreign materials Made in London, UK Stockholm, Sweden
Slide 16 of 34 What does this mean? 2008 Plastic Surgeons performed 10.2 Million procedures Corrections, deletions, augmentations, & enhancements What will happen when you can design organs, limbs,...?
Slide 17 of 34 Hugh Herr "When you go into my closet, there are many, many pairs of legs. I have a running pair, I have a bionic walking pair, limbs that are waterproof," he says. "I have various legs to climb mountains and to sense steep ice walls, other feet that wedge into small rock fissures [and] others that stand on small rock edges the width of a coin. My biological body will degrade in time…, but the artificial part of my body will improve over time since I can upgrade. http://www.npr.org/2011/08/10/137552538/the-double- amputee-who-designs-better-limbs
Slide 18 of 34 iPSCs (Induced Pluripotent Stem Cells)
Slide 19 of 34 Engineering Humans Engineering Children Already determine gender & eliminate some diseases What amount of intelligence will your child have? Will you give them the 577R genotype in the ACTN3 gene? 84% of Africans have it, 49% of Eurasians have it What about Olympic athletes? Engineering Adults Hear ultrasound frequencies Telescopic vision
Slide 21 of 34 Exit Interview Comments …take the class only if you enjoy biology or the sciences. If he/she doesnt wish to go into the field of science, Id highly dissuade them from taking the course. If a student is only taking a course to have it on her transcript then she will have a horrible time. …you must learn a ton of information in a short period of time.
Slide 22 of 34 Page 2 AP Biology is nothing like honors Biology. …the teacher should have removed students from the class who were not up to the standards of the course. Some people played on the computer or did not pay attention in class. Why are they still here?
Slide 23 of 34 2010 AP Biology Results Pass Rate = 90% 5s = 52% 5 + 4 = 77% Students = 64
Slide 24 of 34 Why this class is difficult… 1. Biology knowledge base is deficient How many years ago did you take Honors Biology? 2. Honors Biology AP Biology 3. 55 Chapters (1,230 pages) 4. 3 credits vs. 8 credits
Slide 25 of 34 Why this class not difficult… 1. Clear expectations Vocabulary & Objectives 2. Information is readily available 3. Course Materials sourced from 3 Biology textbooks 4. Course materials are easily accessible 5. Few complicated concepts
Slide 26 of 34 What is a College Level Course? Student-Driven Learning Role of teacher is to highlight some important points Will NOT cover every concept in class students are expected to work independently outside the class
Slide 30 of 34 Class Discussions You WILL be called on to attempt an answer I want to hear what you have to say Make all questions and comments relevant to the content discussion If your question is off topic, write it down and ask it later
Slide 32 of 34 Background Undergrad: Philosophy & Biochemistry Masters: Medical Economics & Epidemiology HHMI (Howard Hughes Medical Institute) Cohort Inaugural Fellow (2008) @ University of Florida Translational Medicine Institute (2011) @ UF AP Summer Institute (2007, 2008, & 2009) Nova SE, BCPS, and Stanford University AP Annual Conference (2008) in Seattle, WA
Slide 34 of 34 Assignments Diagnostic Test due by 2:00 am Tonight !!! Biology: Diagnostic Test – (45 minutes) http://www.quia.com/quiz/3231852.html Student Information Survey http://www.quia.com/sv/540447.html Any questions on the Student Survey, email me @ bb@ap- bio.combb@ap- bio.com Due by 2:00 am Tonight !!
Slide 35 of 34 Assignment (Page 2) http://www.ap-bio.com Student Handbook 2011: Printout, Read, & then Sign Due Wednesday 8/24/11 Statement of Understanding (Page 4) Lab Safety Contract (Page 4) Academic Integrity (Honor Code) (Page 5) AP Exam Exception (Page 6) Homework / Summer Project Due in class Wednesday 8/24/11
Slide 36 of 34 Assignment (Page 3) If you have not gotten emails from Mr. Boswell, make sure you add name to email list Chapters 2 & 3 tomorrow