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2. Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 2 Table 1 The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. Diacon, Andreas; Pym, Alexander; Grobusch, Martin; Patientia, Ramonde; Rustomjee, Roxana; Page-Shipp, Liesl; Pistorius, Christoffel; Krause, Rene; Bogoshi, Mampedi; Churchyard, Gavin; Venter, Amour; Allen, Jenny; Palomino, Juan; De Marez, Tine; van Heeswijk, Rolf; Lounis, Nacer; Meyvisch, Paul; Verbeeck, Johan; Parys, Wim; de Beule, Karel; Andries, Koen; Neeley, David New England Journal of Medicine. 360(23):2397-2405, June 4, 2009. Table 1 Demographic and Baseline Clinical Characteristics and Drug Susceptibility of the Patients.

3. Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 3 Table 2 The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. Diacon, Andreas; Pym, Alexander; Grobusch, Martin; Patientia, Ramonde; Rustomjee, Roxana; Page-Shipp, Liesl; Pistorius, Christoffel; Krause, Rene; Bogoshi, Mampedi; Churchyard, Gavin; Venter, Amour; Allen, Jenny; Palomino, Juan; De Marez, Tine; van Heeswijk, Rolf; Lounis, Nacer; Meyvisch, Paul; Verbeeck, Johan; Parys, Wim; de Beule, Karel; Andries, Koen; Neeley, David New England Journal of Medicine. 360(23):2397-2405, June 4, 2009. Table 2 Incidence of Adverse Events.

4. Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 4 Figure 1 The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. Diacon, Andreas; Pym, Alexander; Grobusch, Martin; Patientia, Ramonde; Rustomjee, Roxana; Page-Shipp, Liesl; Pistorius, Christoffel; Krause, Rene; Bogoshi, Mampedi; Churchyard, Gavin; Venter, Amour; Allen, Jenny; Palomino, Juan; De Marez, Tine; van Heeswijk, Rolf; Lounis, Nacer; Meyvisch, Paul; Verbeeck, Johan; Parys, Wim; de Beule, Karel; Andries, Koen; Neeley, David New England Journal of Medicine. 360(23):2397-2405, June 4, 2009. Figure 1 Mean (+/-SD) Plasma Concentration-Time Profiles for TMC207 at Week 2 and Week 8. Dosing was selected to maintain plasma TMC207 concentrations above a target average steady-state plasma concentration of 600 ng per milliliter. T bars indicate standard deviations.

5. Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 5 Figure 2 The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. Diacon, Andreas; Pym, Alexander; Grobusch, Martin; Patientia, Ramonde; Rustomjee, Roxana; Page-Shipp, Liesl; Pistorius, Christoffel; Krause, Rene; Bogoshi, Mampedi; Churchyard, Gavin; Venter, Amour; Allen, Jenny; Palomino, Juan; De Marez, Tine; van Heeswijk, Rolf; Lounis, Nacer; Meyvisch, Paul; Verbeeck, Johan; Parys, Wim; de Beule, Karel; Andries, Koen; Neeley, David New England Journal of Medicine. 360(23):2397-2405, June 4, 2009. Figure 2 The Proportion of Patients with Positive Sputum Cultures and Time to Conversion. Proportions of positive cultures were determined according to the mycobacteria growth indicator tube (MGIT) system.

6. Copyright © 2009 Massachusetts Medical Society. All rights reserved. Published by Massachusetts Medical Society. 6 Figure 3 The Diarylquinoline TMC207 for Multidrug-Resistant Tuberculosis. Diacon, Andreas; Pym, Alexander; Grobusch, Martin; Patientia, Ramonde; Rustomjee, Roxana; Page-Shipp, Liesl; Pistorius, Christoffel; Krause, Rene; Bogoshi, Mampedi; Churchyard, Gavin; Venter, Amour; Allen, Jenny; Palomino, Juan; De Marez, Tine; van Heeswijk, Rolf; Lounis, Nacer; Meyvisch, Paul; Verbeeck, Johan; Parys, Wim; de Beule, Karel; Andries, Koen; Neeley, David New England Journal of Medicine. 360(23):2397-2405, June 4, 2009. Figure 3 Median (+/-SD) Log10 Count of Colony-Forming Units (CFUs). Median (+/-SD) log10 CFU counts over time are shown in the subgroup of 22 patients who provided pooled-sputum samples.