1. FT in diagnostic of HBV Prognostic Value of FibroTest in HCV Ngo et al, ClinChem 2006 A Prospective Analysis of the prognostic value of biomarkers (FirboTest) in patients with chronic hepatitis C

2. FT in diagnostic of HBV Study design Included patients

3. FT in diagnostic of HBV 5 year survival curves according to FibroTest severity groups at baseline FT classifies corectly Survival without HCV complications (group 1, no or minimal fibrosis; patients with baseline FibroTest of 0.00–0.31.) Survival rate without HCV complications : 93% [95% confidence interval (CI), 91%–96%; 29 complications] FT 0.96 vs Biopsy 0.91P=0.01 Pugh0.80 P=0.006 APRI 0.82 P=0.03 Forns 0.86 P=0.04 Survival without HCV related death (group 2, moderate fibrosis: patients with baseline FibroTest of 0.32–0.58.) Survival without HCV related death: 98% (95% CI, 96%–99%; 9 deaths). FT 0.96 vs Biopsy 0.87P=0.04 Pugh0.89 P=NS APRI 0.82 P=0.02 Forns 0.87 P=0.04 Overall Survival (group 3, severe fibrosis: patients with baseline FibroTest of 0.58–1.00.) Overall survival : 95% (95% CI, 93%–97%; 20 deaths), which was lower, although not substantially, than that for paired controls (97%; 95% CI, 97%–98%; P = 0.06) Overall survival of the untreated severe group was substantially lower than that of paired Controls

4. FT in diagnostic of HBV Prognostic value ROC of FibroTest and biopsy FibroTest vs biopsy fibrosis staging for survival without HCV-related complications. FibroTest AUROC (0.96; 95% CI, 0.93%–0.97%) was greater than fibrosis staging AUROC (0.91; 95% CI, 0.85%–0.94%; P=0.01) FibroTest vs biopsy fibrosis staging for survival without HCV-related death. FibroTest AUROC (0.96; 95% CI, 0.93%–0.98%) was greater than fibrosis staging AUROC (0.87; 95% CI, 0.70%–0.94%; P =0.046). FibroTest vs biopsy fibrosis staging for overall survival. FibroTest AUROC (0.76; 95% CI, 0.63%– 0.84%) was not substantially different from fibrosis staging AUROC (0.66; 95% CI, 0.52%–0.78%). FibroTest Biopsy FibroTest Biopsy FibroTest Biopsy

5. FT in diagnostic of HBV Conclusions FibroTest has prognostic values at least similar to that of liver biopsy, with the advantage of being non invasive FibroTest has significant better prognostic values than that of other non invasive biomarkers

6. FT in diagnostic of HBV