1. AVR Distribution by Age, Cusp, and CAD Data 932 consecutive AVR patients 1993–2004 Roberts, Circulation. 2005; 111:920–925

2. Cusp Type and/or CAD Prevalence in AVR pts. over age 70 AVBG Transcatheter Valve Bicuspid w/o CAD20%+ Contraindicated * Bicuspid w/CAD20%+ Contraindicated * Tricuspid w/o CAD21%++ Tricuspid w/ CAD39%+ Contraindicated * Alternative Therapies by Cusp Type and CAD Edwards LifeScience PARTNER Trial protocol European Association of Cardio-Thoracic Surgeons guidelines European Society of Cardiology guidelines * Patients with Bicuspids or Untreated Significant CAD are contraindicated for transcather valve implantaion Future CAD Intervention Bicuspid

3. Will Transcatheter procedures be applicable to broad market segment? AttributeNo CADCAD Tricuspid 21%39% Bicuspid 20% Key PARTNER Trial Exclusion Criteria: Aortic valve is a congenital unicuspid or bicuspid valve; or is non-calcified Untreated clinically significant coronary artery disease requiring revascularization AVR Patients Age 70+ Data 932 consecutive AVR patients 1993–2004 Roberts, Circulation. 2005; 111:920–925