1. Janeway’s Immunobiology Seventh Edition Janeway’s Immunobiology Seventh Edition Chapter 10 Dynamics of Adaptive Immunity Chapter 10 Dynamics of Adaptive Immunity Steffen Thiel st@microbiology.au.dk

2. ca.1 uge

9. DC CD4 T cell T H 1 T H 2 T H 17 Treg

15. Inhibition af andre CD4 T celler

17. Parasit infektion T H 1 response T H 2 response

18. Nye adhesionsmolekyler Nye muligheder Effect T Effect T TNF-  VCAM/ICAM Effect T Macro phag

19. Movie – lymphocyte migration

21. Ingen IL-12 Ingen egne T celler - men IL-12 IL-12 holder gang i T H 1 celler

23. Memory

28. Memory T-cells

29. Hvordan ser overfladen af en memory T cell ud

32. Ingen CD4 T cellsIngen memory Godt CD8 T celle respons

35. Published online 26 September 2007 | Nature 449, 390 (2007) HIV vaccine failure prompts Merck to halt trial ---------------------------- The Thai-trial – publiceret oktober 2009: Hvad pressen og producenterne skrev: "Although the level of protection was modest, we think the study is a major scientific advance,“ said Colonel Jerome Kim, HIV vaccines product manager for the U.S. Army. The controversial $105 million trial, the largest and most expensive AIDS vaccine study ever conducted, took 6 years and involved more than 16,000 volunteers at eight sites in Thailand Rent faktisk: 51 vaccinated people had become infected within 3 years of receiving their last shot, as compared with 74 people in the placebo group. Immunity. 2010 Oct 29;33(4):542-54. Induction of immunity to human immunodeficiency virus type-1 by vaccination. McElrath MJMcElrath MJ, Haynes BF.Haynes BF A recent vaccine regimen has shown modest efficacy against HIV-1 acquisition.