11 Present research on epoxide hydrolase Resolution of:…… as chiral building blocks for pharmaceuticalsMore info: dr. Carel Weijers!
12 Development and integration of stable aldolases in the synthesis of enantiopure functionalized nitrogen heterocycles Maud CABRIÈRES, Maurice FRANSSEN
13 IBOS PROJECT: 5 partners IBOS: Integration of Biosynthesis and Organic Synthesis ProgramDr. Franssen/Prof. Sudhölter (Org. Chem. WU)Dr. van der Oost/Prof. de Vos (Microbiology WU)Prof. Kieboom, University of Leiden (Bio-org. Chem. UL)Prof. Rutjes, University of Nijmegen (Org. Chem. KUN)Industrial partner: DSM
14 General framework of IBOS project Schematic overviewof the project:Final goal: integration of new generation of Aldolases in a cascade of biocatalytic conversions, aiming at the synthesis of novel nitrogen heterocyclic compounds:AldehydeHydroxynitrile Lyase (HNL)Cyanohydrin
15 C-C bond formation relevance “ Carbon- carbon bond formation lies at the heart of many organic synthesis ”Today’s fine chemistry challenge: forming building blocks with complete control of the stereochemistry of stereogenic centresAldol reaction: one of the most powerful and famous method to enlarge carbon skeleton