1. Fructose

2. FRUKTOSE (LEVULOSE) Blood Diabetes mellitus
Glucose
Galactose
Fructose
Food
Honey
Fruits
Potato
Onion
+ glucose
+ sucrose
Degradation of sucrose
Diabetes mellitus
Influence on lipid metabolism

3. Effect of fructose Ingestion results in Chelating effect
Obesity
[LDL] á
[TRIGLYCERID] á
Metabolic syndroms
Chelating effect Cu Zn Cr
Insulin resistence (DM Type II. típus)
Glycation of proteins

4. FRUCTOSE

5. Absorption of monosaccharides
Transporters:
GLUT-5
GLUT-2
Glucose

6. Absorption of carbohydrates
2Na+
Lactose
Lactase
Gal K+
Na+
ATP
SGLT1
K+Na+ATP-ase
Starch
Amylase
a-glucosidase
Glu
ADP K+
Sucrose
Sucrase
Fru
GluT5
GluT2
Intestinalis lumen
Entherocytes
Extracellular space

7. GLUCOSE
FRUCTOSE

8. D-fructose in liquor and in seminal plasma
Peripherial neurons. Diabetic hyperglycaemia
Accumulation of Sorbitol à periferial neuropathy

9. Degradation of fructose in
muscle
liver

10. Formation of methylglyoxal

11. Catabolism of methylglyoxal

12. Deficiency of liver fructokinase
Benign disease
Fructoseuria

13. FRUCTOSE
GLUCOSE
FRUCTOSE

14. Deficiency of Fructose-1-phosphate aldolase (Fructose intolerance)
Hereditery fructose intolerance (HFI)
fruktosemy
Deficiency of fructose 1,6-bisphosphate aldolase B
Def, of aldolase B
vomiting
hypoglycaemia
Cachexy
hepatomegaly
jaundice
coagulopathy
Metabolic acidosis
Coma
renal Fanconi syndrome

15. GLUCOSE
FRUCTOSE

17. Figure 1 Fructose-induced production of uric acid in the hepatocyte
Nakagawa T et al. (2005) Hypothesis: fructose-induced hyperuricemia as a causal mechanism for the
epidemic of the metabolic syndrome Nat Clin Pract Neprol 1: 80–86 doi: /ncpneph0019

18. Foszfát-hiány
[Fruktóz-1-P] á
GLUKÓZ
FRUKTÓZ
A hipoglikémia kialakulásának valószínű oka

19. GLUKÓZ
FRUKTÓZ