1. SPHERONIZER AND MARUMERISERS Name:- Umme Salma Masters of Pharmacy 1 st Sem (IP)

2. CONTENT  Definition  Advantages  Spheronization process  Extrusion  Standard features of marumerizer  Different types of spheronizers  Key spheronization factors  Product parameters  Reference

3. Definition Spheronization or marumerisation, is a rapid and flexible process where pharmaceutical products are made into small spheres, or spheroids of diameter ranging from about 0.5mm to 1mm where as in marumerization 0.6mm t0 1.2mm.

4. Advantages  Optimum flow and handling characteristics.  More reproducible packing into small container.  Minimum surface area/volume ratio.  Optimum shape for coating and for controlled release.

5. Advantages  Easy mixing of non-compatible products.  Elimination of dust.  Improve hardness and friability.

6. Spheronization process  Dry mixing of ingredients  Wet massing  Extrusion  Spheronization  Drying  Screening

7. Extrusion  It produces rod shaped particles of uniform diameter from the wet mass.  The extrudate particles breaks at similar lengths under then own weight.

8. Extrusion Based on their feed mechanism extruders divided into 3 types:- 1.Screw feed extruder(axial and radial) 2.Screen basket extruder. 3.Gear extruder.

10. THE SPHERONIZATION PROCESS Basic configuration:- Machine consists of a rotating friction disk, designed to increase friction with the product, which spins at high speed at the bottom of cylindrical bowl.

11. THE SPHERONIZATION PROCESS

13. Standard features of marumerizer  Perfect cGMP design,smooth covering. Explosion free design. Integration with mill is possible. Video monitoring the process.

14. Different types of spheronizers

16. Key spheronization factors 1.Disc speed and load. 2.Disc groove geometry. 3.Disc diameter and speed. 4.Product parameters. 5.Retention time.

17. Product parameters 1)Auxillary equipment:-improve the efficiency. 2)Water jacket:-to drive off moisture. 3)Air introduction:-prevents dust. 4)Non- stick coatings :-for ease of use with sticky materials.

18. Reference  www.caleva.com/faq/where-cani-find-a-general.  www.researchgate.net/publication/285070866...