1. DISCOVERY OF NITROGLYCERIN & IT’S USES Nitroglycerin was the first practical explosive produced that was stronger than black powder. It was first synthesized by the Italian chemist Ascani Sobrero in 1847, working under Théophile-Jules Pelouze at the University of Turin. Sobrero initially called his discovery pyroglycerine & warned vigorously against its use as an explosive. Ascani Sobrero Théophile-Jules Pelouze Name: Rathi Rohitkumar Subhash Final Year B.Pharm Batch : D Roll No. 89

2. Alfred Bernhard Nobel was a Swedish chemist, engineer, inventor, businessman, and philanthropist. He held different patents, dynamite is the most famous. Nitroglycerin was later adopted as a commercially useful explosive by Alfred Nobel. Emil Oskar Nobel, and several factory workers were killed in an explosion at the Nobel's' armaments factory in 1864 in Heleneborg. Alfred Nobel and his company's developing Dynamite in 1867. This was made by mixing nitroglycerin with Diatomaceous earth. Scan for info Alfred Bernhard Nobel Alfred Nobel's patent application from 1864

3. William Murrell : Murrell is best known for being one of the first to recognize the clinical benefits of glyceryl trinitrate (also known as nitroglycerin) for the management of patients with angina pectoris. He began treating his patients with small diluted doses of nitroglycerin in 1878, and this treatment was soon adopted into widespread use after Murrell published his results in the journal The Lancet in 1879. He also describes in detail the effects of nitroglycerin experienced by testing the drug on himself. Ironically, Alfred Nobel, the inventor of Nitroglycerin for use as an explosive, received nitroglycerin for treatment of angina. Nitroglycerin came into medical use in 1878. It is on the World Health Organization's List of Essential Medicines. In 2017, it was the 143rd most commonly prescribed medication in the United States, with more than four million prescriptions.

4. Wartime production rates : Large quantities of nitroglycerin were manufactured during World War I and World War II for use as military propellants and in military engineering work. During World War I, HM Factory, Gretna, the largest propellant factory in Britain, produced about 800 tons of cordite RDB per week. This amount required at least 336 tones of nitroglycerin per week (assuming no losses in production). The Royal Navy had its own factory at the Royal Navy Cordite Factory, Holton Heath, in Dorset, England. A large cordite factory was also built in Canada during World War I. The Canadian Explosives Limited cordite factory at Nobel, Ontario, was designed to produce 1,500,000 lb. (680 t) of cordite per month, requiring about 286 tones of nitroglycerin per month.

5. Uses of Nitroglycerine : For the treatment of angina, acute myocardial infarction, severe hypertension, and acute coronary artery spasms. It may also be given as a sublingual or buccal dose in the form of a tablet placed under the tongue or a spray into the mouth for the treatment of an angina attack. Decrease pain associated with dysmenorrhea. once researched for the prevention and treatment of osteoporosis. GTN is also used in the treatment of anal fissures, though usually at a much lower concentration than that used for angina treatment. Tentative evidence indicates efficacy of glyceryl trinitrate in the treatment of various tendinopathies, both in pain management and acceleration of soft tissue repair.