1. Toxicogenomics: A 2020 Vision
Zhichao Liu, Ruili Huang, Ruth Roberts, Weida Tong 
Trends in Pharmacological Sciences 
Volume 40, Issue 2, Pages (February 2019)
DOI: /j.tips
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2. Figure 1
The Pyramid of Toxicogenomics (TGx) towards Regulatory Decision Making. Some outstanding questions and potential solutions for promoting TGx in respect of decision making are shown. iPSC, Induced pluripotent stem cell.
Trends in Pharmacological Sciences  , DOI: ( /j.tips )
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3. Figure 2
Application of Novel Genomics Technologies in Toxicogenomics (TGx). Some novel genomics technologies such as RNA-Seq and TempO-Seq™ have been well established in the TGx field. The novel genomics features beyond mRNA, including miRNA, noncoding RNA, and circular RNAs, provided extra resolution for identifying and understanding the underlying mechanism of toxicities. Bioinformatics approaches, including data integration, systems biology, and the network, could serve as a bridge to facilitate the utilization of novel genomics technologies in TGx.
Trends in Pharmacological Sciences  , DOI: ( /j.tips )
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4. Figure 3
Key Challenges of Reproducibility in Toxicogenomics. The reproducibility of toxicogenomics include both biological and technical sides. The data are generated from different cell lines in various labs with different technologies. The repeatability and reproducibility necessities have different influential factors including cell types, genomics platforms, and data analysis. cirRNA, Circular RNA; ncRNA, noncoding RNA.
Trends in Pharmacological Sciences  , DOI: ( /j.tips )
Copyright © 2018 Elsevier Ltd Terms and Conditions