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1)Dep. of Phys, Kyoto Univ., Kyoto, Japan,

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Presentation on theme: "1)Dep. of Phys, Kyoto Univ., Kyoto, Japan,"— Presentation transcript:

1 1)Dep. of Phys, Kyoto Univ., Kyoto, Japan,
On-time Imaging of the distribution of 10B in BNCT by the detection of 478keV prompt gammas with Electron Tracking Compton Camera (ETCC) TPC Pixel Scintillator Arrays (PSA) RI reagent 40cm New Medical ETCC made by Kyoto COI project (2015) First Medical ETCC(2008) Introduction of Electron Tracking Compton Camera (ETCC) ETCC in Medical Imaging Result from Neutron Beam test Summary 16/Dec/2015 T.Tanimori1 A.Takada, T.Mizumoto, S.Sonoda, D.Tomono on behalf of SMILE team 1)Dep. of Phys, Kyoto Univ., Kyoto, Japan,

2 Electron-Tracking Compton Camera (ETCC) in Astro
ARM (Angular Resolution Measure) SPD (Scatter Plane Deviation) 30cm-cube Gaseous Time Projection Chamber --- tracking of recoil electron --- SPD (Scatter Plane Deviation) + dE/dx + a Scintillator Array for scattered g Gaseous TPC Large Field of View >4 str m-PIC Scintillator Array SPD ~100o Image of 3 point sources(662keV) with several SPD resolution no use of SPD SPD 90o (<80keV) SPD 45o (>80keV) SPD ~200o SPD ~100o

3 Imaging and Point Spread Function (PSF)
General Imaging (measures q and f) Two directional angles f(q, f) = x g(q, f) = y Transformation Compton Imaging (only q ) Electron Tracking Imaging imaging with q and f PSF(Q ~20-40o) (Q ~ average of q) Q imaging with only q PSF(Q ~1o) SPD g e q g’ f 2D position q f CC y x Compton Camera -> only electrically collimated ETCC -> Electrically Focused Tanimori et al., ApJ (2015), 810, 28

4 Point Spread Function in Compton Camera
Efficiency for analyzed gammas useful imaging SMILE-I type ETCC 10 cm-cubic, Ar (1 atm), 1 R.L. 30 cm-cubic Ar (1 atm), 1 R.L. 30 cm-cubic Ar (1 atm), 3 R.L. 40 cm-cubic CF4 (3 atm), 3 R.L. 50 cm-cubic, CF4 (3 atm), 10 R.L. 10-2 10-3 10-4 10-5 PSF(q) =½ gammas from point in radius of q Efficiency Conventional CC PSF(3-50o) SPD 50o ARM 5o PSF(7o) SPD 25o ARM 5o PSF(5o) SPD 5o ARM 2o PSF(1.2o) PSF of Compton Camera is by  (NOT by ARM). PSF of ETCC is Max{ARM, SPD} Sensitivity is perfectly determined by Eff. x PSF ARM SPD Conventional CC 120o

5 Compact ETCC for multipurpose medical imaging
10x10x10cmETCC (2014) Clear images for >300keV g in mice (08-12) (I-131:364keV) Thyroid gland phantom from one direction  364keV 10x10x15cmETCC (15) Tacking efficiency 10% -> 100% Fast DAQ 30Hz -> ~1KHz Good Angular resolution 10o ->5o x5 improved 1st Medical 10cm-cube ETCC(06~12) Multicolor image (3 energy gs) 2014type ETCC W(I-131:364keV) 2015 2014 2006 5

6 Proton Therapy Beam-on Imaging with advanced ETCC for Astrophysics
Strong Background Rejection by dE/dx of tracks in gas TPC 140MeV p-bean ~1nA at RCNP of Osaka Univ.

7 Imaging Test in Neutron Beam
KUANS Compact neutron source (Kyoto) 3.5MeV p-lineac + Be target thermal neutron /cm2s (3x103 cm2s) Target 10B 4x10-3mol -> body ~20kg Polyethylene (5%B) target Ge ETCC Thermal n 40cm ETCC 10x10x15cm 1.5atm Ar Efficiency Trigger rate ~15Hz (6hrs Observ.) Back Projection of 478±47keV D=8cm ETCC Energy Spectrum Ge

8 Separation of 478keV from511keV
22Na source set on Polyethylene brock 22Na is quite stronger than 478keV from 10B 478 keV±15% 478 keV -15% ~ -7.5% 511 keV +7.5% ~+15% Poly-brock 22Na Ge ETCC Energy Spectrum GSO DE/E ~12% Main Position source -> possibly Collimator In ETCC Observation, 511keV is expected to smaller flux than 478keV Even if 511keV appeared strongly, GAGG DE/E ~6% eparation is OK and Imaging gives quite strong separation !!

9 BNCT-SPECT is Possible?
D L T DW D+t Type D (mm) T L Aperture (D/(D+T))2 DW (D/L)2 Weight 30x30cm (kg) lead 99mTc :140keV 1.4 0.15 32 0.82 2.1x10-3 5.9 High E,300keV 3.1 2.0 60 0.37 2.7x10-3 22.6 BNCT 487keV 2 12 200 0.02 10-4 204 SPECT Au-198(410keV Typical dose for SPECT 500MBq Similar number of g for BNCT-SPECT 0.5 x550 ~ 250GBq needed BNCT 106g/cc.s. 10kg-> g/s 10GBq Heavy collimator => Strong Background Source .

10 Imaging for Boron chemicals in BNCT
Imaging of Boron chemicals(BC) BC+ 18F for PET However, no guarantee for BC+18F with same distribution as BC in body Imaging for BNCT in human 10B a few mmol/cc human 6x104g ETCC eff. 1x10-3 x 3-5 modules Required 478keV g 105 gammas/5kg (5-7mm resolution) Measurement Time a few 10sec. Needed neutron flux 106n/cm2s 3 order weaker beam than treatment -> Modulated Mode Imaging System of mice is inevitable for developing new BCs 10B a few mmol/cc mouse 20g Use enhanced 10B ETCC eff. 5x10-4 Required 478keV gammas ~ (1-2mm resolution) Measurement time 100sec. Needed neutron flux 106n/cm2s Next Development for Medical ETCC ( a few years later) Resolution -> 2-3mm in human Efficiency  -> >1% (3atm CF4 20cmETCC) High counting rate ~100KHz Solution: Small neutron source + ETCC

11 Features of ETCC for Molecular Imaging & Nuclear Medicine
ETCC provides clear images by well-defined PSF similar to Optical camera with small background ETCC would be a versatile gamma-ray imager in Medicine covering gammas from lots of RIs. ETCC would enable following new approaches Low Dose Imaging New Tracers with new RIs (decay time ~1day) Visualizations of immunity and enzyme : Multi RI Tracer Image 99mTc +18F Imaging for beam therapy (proton, ion, BNCT)           

12 Acknowledgements SMILE Team: H.Kubo1,, S.Iwaki1, T.Kishimoto1, S.Komura1, Y.Matsuoka1, , T.Miyamoto, K.Miuchi2 Y.Mizumura1, K.Nakamura1, M.Oda1, J.D.Parker1, T.Sawano3 ,S.Sonoda1, T.Takemura1, 1)Dep. of Physics, Kyoto University, Japan, 2) Dep.of Physics, Kobe University, Japan, 3)Dep. of Physics, Kanazawa University, Japan Center of Innovation Program in Kyoto University(The Last 5X innovation R&D Center for a Smart, Happy, and Resilient Society) with CANON co. Ltd. Prof. H.Kimura : Department of Analytical & Bioinorganic Chemistry, Kyoto pharmaceutical University Japan Prof. T.Nagae, Dr. H.Fujioka, Mr. M.Hirose, Hadron Group, Department of Physics, Kyoto Univ. Japan Dr. S.Kabuki, Department of Medicine, Tokai Univ. Japan

13 Supplemental slides

14 SPD resolution in TPC with mPIC
Multiple scattering angle e- energies E>80kev E<80kev Present 800mm pitch Linear Fitting Between vertex to 1cm Electron track vertex 1cm U,V,X electrodes in TPC Spline Fitting Between vertex to 0.5cm Scattering 1mm in gas => <1mm in Solid state Real hits 500keV Gamma Ee ~150keV SPD: 15o - 5o >1MeV Gamma Ee ~300keV SPD: 10o - 2o PSF(q =1.2o) SPD 5o ARM 2o PSF(q ) q -> 1o~2o possible

15 Comparison with Semi-Conductor in Medical use
With Similar cost Type BG rejection ARM@511keV +PSF Efficiency Analysis time Area (cm2) Detectable gamma (relative) Ge × ~2o (~50o) Few % x ~10 3x3  ~10 Si ~3o (50o) few % 5x5 ~10 Gas ETCC >x   (1~10o) 0.1~a few %    1 30x30  100~ 1000


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