Presentation is loading. Please wait.

Presentation is loading. Please wait.

Fig. 4 DDO-5936 arrests the cell cycle in HCT116 cells.

Published byKarina Kristiansen Modified over 5 years ago

Similar presentations

Presentation on theme: "Fig. 4 DDO-5936 arrests the cell cycle in HCT116 cells."— Presentation transcript:

1 Fig. 4 DDO-5936 arrests the cell cycle in HCT116 cells.
DDO-5936 arrests the cell cycle in HCT116 cells. (A) Western blot analysis of Cdc37, Hsp90, GR, p-GR, AKT, p-AKT, ERK1/2, and p-ERK1/2 protein expression levels in Cdc37-WT HCT116 cells and corresponding Cdc37-KO HCT116 cells after treatment with 0, 10, or 25 μM DDO-5936 for 24 hours. β-Actin was used as a loading control. Data are representative of three independent experiments. (B) Western blot analysis of Cdc37, CDK2, CDK4, CDK6, p21, p27, cyclin D1, and cyclin D3 protein expression levels in Cdc37-WT HCT116 cells and corresponding Cdc37-KO HCT116 cells after treatment with 0, 10, or 25 μM DDO-5936 for 24 hours. β-Actin was used as a loading control. Data are representative of three independent experiments. (C) Top: Cell cycle distribution measured by propidium iodide (PI) staining of Cdc37-WT HCT116 cells and corresponding Cdc37-KO cells after treatment with 0, 10, or 25 μM DDO-5936 for 24 hours. Bottom: The cell cycle distribution is represented as a graphic histogram. Data are representative of three independent experiments as the means ± SD (***P < 0.001). Lei Wang et al. Sci Adv 2019;5:eaax2277 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

Download ppt "Fig. 4 DDO-5936 arrests the cell cycle in HCT116 cells."

Similar presentations

Fig. 5 Correlation of RNA expression and protein abundance.

Fig. 5 Correlation of RNA expression and protein abundance.
Fig. 2 Transport properties of a BP transistor at low temperature.

Fig. 2 Transport properties of a BP transistor at low temperature.
Fig. 3 The electrical contact of direct-printed and reconfigured liquid metals. The electrical contact of direct-printed and reconfigured liquid metals.

Fig. 3 The electrical contact of direct-printed and reconfigured liquid metals. The electrical contact of direct-printed and reconfigured liquid metals.
Fig. 1 TET2 is a coactivator of ERα.

Fig. 1 TET2 is a coactivator of ERα.
Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,

Fig. 2 Global production, use, and fate of polymer resins, synthetic fibers, and additives (1950 to 2015; in million metric tons). Global production, use,
Fig. 2 CFD results. CFD results. Results of CFD simulations in horizontal (left column) and vertical (right column) cross-sections. All models oriented.

Fig. 2 CFD results. CFD results. Results of CFD simulations in horizontal (left column) and vertical (right column) cross-sections. All models oriented.
Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)

Vibrational spectra of medieval human bones (Leopoli-Cencelle, Italy)
Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.

Fig. 5 Thermal conductivity of n-type ZrCoBi-based half-Heuslers.
Fig. 1 Map of water stress and shale plays.

Fig. 1 Map of water stress and shale plays.
Fig. 1 Examples of experimental stimuli and behavioral performance.

Fig. 1 Examples of experimental stimuli and behavioral performance.
Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.

Fig. 2 Some examples of weekly forecasts (the number of the forecasts are reported on Table 1). Some examples of weekly forecasts (the number of the forecasts.
Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.

Fig. 4 Resynthesized complex boronic acid derivatives based on different scaffolds on a millimole scale and corresponding yields. Resynthesized complex.
Fig. 6 Comparison of properties of water models.

Fig. 6 Comparison of properties of water models.
Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.

Fig. 1 Mean and median RCR (Relative Citation Ratio) of Roadmap Epigenomics Program research articles for each year. Mean and median RCR (Relative Citation.
Fig. 2 Influence of the Roadmap Epigenomics Program on the field of epigenomics research. Influence of the Roadmap Epigenomics Program on the field of.

Fig. 2 Influence of the Roadmap Epigenomics Program on the field of epigenomics research. Influence of the Roadmap Epigenomics Program on the field of.
Fig. 3 Glucose- and structure-dependent insulin release.

Fig. 3 Glucose- and structure-dependent insulin release.
Fig. 3 Scan rate effects on the layer edge current.

Fig. 3 Scan rate effects on the layer edge current.
Fig. 3 Rotation experiment, setup.

Fig. 3 Rotation experiment, setup.
Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.

Fig. 1 Product lifetime distributions for the eight industrial use sectors plotted as log-normal probability distribution functions (PDF). Product lifetime.
Fig. 5 EGLN2-mediated HIF1A down-regulation promotes ferroptosis.

Fig. 5 EGLN2-mediated HIF1A down-regulation promotes ferroptosis.

Similar presentations

Ads by Google